{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:59:30Z","timestamp":1790164770370,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570726"],"award-info":[{"award-number":["81570726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600609"],"award-info":[{"award-number":["81600609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411971200"],"award-info":[{"award-number":["16411971200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16410723200"],"award-info":[{"award-number":["16410723200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai JiaoTong University School of Medicine","award":["2014"],"award-info":[{"award-number":["2014"]}]},{"name":"Commission of Health and Family Planning of Pudong District","award":["PW2015D-5"],"award-info":[{"award-number":["PW2015D-5"]}]},{"name":"Fourth Round of Three-Year Public Health Action Plan of Shanghai by the Shanghai Municipal Commission of Health and Family Planning","award":["15GWZK0202"],"award-info":[{"award-number":["15GWZK0202"]}]},{"name":"Fourth Round of Three-Year Public Health Action Plan of Shanghai by the Shanghai Municipal Commission of Health and Family Planning","award":["20164Y0079"],"award-info":[{"award-number":["20164Y0079"]}]},{"name":"Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai","award":["2017YQ053"],"award-info":[{"award-number":["2017YQ053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Previous epidemiological studies had inconsistent results regarding the relationship between blood lead level (BLL) and adiposity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to investigate the associations of BLL with body mass index (BMI) particularly using Mendelian randomization analyses and examine the interaction between obesity-predisposing genes and BLL on the associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting<\/jats:title>\n                  <jats:p>A total of 3922 participants were enrolled from 16 sites in East China in 2014 from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (ChiCTR-ECS-14005052, www.chictr.org.cn). We calculated the weighted BMI genetic risk score (GRS) based on 29 variants that were identified and validated in East Asians. BLL was measured by atomic absorption spectrometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>BMI was calculated, and BMI \u226525 kg\/m2 was defined as overweight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Multivariable logistic regression analysis demonstrated significant associations between BMI with each unit increase in lnBLL (\u03b2 = 0.24; 95% CI, 0.08 to 0.40; P &amp;lt; 0.001) and each 1-point increase in BMI-GRS (\u03b2 = 0.08; 95% CI, 0.05 to 0.11; P &amp;lt; 0.001). The causal regression coefficients of genetically determined BMI for lnBLL were \u22120.003 (95% CI, \u22120.075 to 0.070), which showed no significance. The GRS modified the association of BLL with BMI and overweight (BMI \u226525 kg\/m2; P for interaction = 0.031 and 0.001, respectively). Each unit of lnBLL was associated with 63% higher odds of overweight (OR 1.63; 95% CI, 1.30 to 2.05) in the highest quartile of GRS, but no significant associations were found in the lower three quartiles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The associations of BLL with BMI and overweight (BMI \u226525 kg\/m2) were significantly modulated by BMI genetic susceptibility.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-00472","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T18:03:36Z","timestamp":1536343416000},"page":"4005-4013","source":"Crossref","is-referenced-by-count":17,"title":["Adiposity Genetic Risk Score Modifies the Association Between Blood Lead Level and Body Mass Index"],"prefix":"10.1210","volume":"103","author":[{"given":"Ningjian","family":"Wang","sequence":"first","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhen","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong 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