{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:29:56Z","timestamp":1791030596176,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"10","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01 DK011006"],"award-info":[{"award-number":["Z01 DK011006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"DOI":"10.1210\/jc.2018-00509","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T18:03:19Z","timestamp":1533578599000},"page":"3668-3677","source":"Crossref","is-referenced-by-count":48,"title":["Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease"],"prefix":"10.1210","volume":"103","author":[{"given":"Tanja","family":"Diana","sequence":"first","affiliation":[{"name":"Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Daiber","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Center for Cardiology 1, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Oelze","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Center for Cardiology 1, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Neumann","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Olivo","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kanitz","sequence":"additional","affiliation":[{"name":"Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stamm","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Center for Cardiology 1, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J","family":"Kahaly","sequence":"additional","affiliation":[{"name":"Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0891-5849(96)00629-6","article-title":"Oxidative stress hypothesis in Alzheimer\u2019s disease","volume":"23","author":"Markesbery","year":"1997","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1423-0127-21-23","article-title":"Oxidative stress and its biomarkers in systemic lupus erythematosus","volume":"21","author":"Shah","year":"2014","journal-title":"J Biomed Sci"},{"issue":"10","key":"key\n\t\t\t\t20181005135538892_B3","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1089\/ars.2007.1569","article-title":"Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies","volume":"9","author":"Gelderman","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"key\n\t\t\t\t20181005135538892_B4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000337976","article-title":"Oxidative stress in graves\u2019 disease","volume":"1","author":"Marcocci","year":"2012","journal-title":"Eur Thyroid J"},{"issue":"10","key":"key\n\t\t\t\t20181005135538892_B5","first-page":"15","article-title":"Role of oxidative stress and selenium in Graves\u2019 hyperthyroidism and orbitopathy","volume":"36","author":"Marcocci","year":"2013","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"key\n\t\t\t\t20181005135538892_B6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2012.4609","article-title":"Mitochondrial redox signaling: Interaction of mitochondrial reactive oxygen species with other sources of oxidative stress","volume":"20","author":"Schulz","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"key\n\t\t\t\t20181005135538892_B7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1042\/CS20110562","article-title":"Free radical biology of the cardiovascular system","volume":"123","author":"Chen","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"9","key":"key\n\t\t\t\t20181005135538892_B8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/ars.2017.7118","article-title":"The adverse effects of environmental noise exposure on oxidative stress and cardiovascular risk","volume":"28","author":"M\u00fcnzel","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2265.2003.01850.x","article-title":"Peripheral parameters of oxidative stress in Graves\u2019 disease: the effects of methimazole and 131 iodine treatments","volume":"59","author":"Abalovich","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"key\n\t\t\t\t20181005135538892_B11","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1681\/ASN.2012111112","article-title":"NADPH oxidases, reactive oxygen species, and the kidney: friend and foe","volume":"24","author":"Sedeek","year":"2013","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"key\n\t\t\t\t20181005135538892_B12","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s00018-002-8520-9","article-title":"The superoxide-generating NADPH oxidase: structural aspects and activation mechanism","volume":"59","author":"Vignais","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"12 Pt 2","key":"key\n\t\t\t\t20181005135538892_B13","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1164\/rccm.2206007","article-title":"Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling","volume":"166","author":"Forman","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20181005135538892_B14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.redox.2015.05.008","article-title":"Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage\/repair","volume":"5","author":"Mikhed","year":"2015","journal-title":"Redox Biol"},{"key":"key\n\t\t\t\t20181005135538892_B15","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"key\n\t\t\t\t20181005135538892_B16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1309\/AJCPZUT7CNUEU7OP","article-title":"Analytical performance and clinical utility of a bioassay for thyroid-stimulating immunoglobulins","volume":"139","author":"Leschik","year":"2013","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"key\n\t\t\t\t20181005135538892_B17","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1210\/jc.2013-4026","article-title":"Clinical relevance of thyroid-stimulating autoantibodies in pediatric graves\u2019 disease-a multicenter study","volume":"99","author":"Diana","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t20181005135538892_B18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/thy.2014.0346","article-title":"Standardization of a bioassay for thyrotropin receptor stimulating autoantibodies","volume":"25","author":"Diana","year":"2015","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20181005135538892_B19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fendo.2017.00028","article-title":"TSH receptor antibody functionality and nomenclature","volume":"8","author":"Kahaly","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/cei.12129","article-title":"A novel bioassay for anti-thyrotrophin receptor autoantibodies detects both thyroid-blocking and stimulating activity","volume":"173","author":"Li","year":"2013","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"key\n\t\t\t\t20181005135538892_B21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1089\/thy.2015.0447","article-title":"Analytical performance and validation of a bioassay for thyroid-blocking antibodies","volume":"26","author":"Diana","year":"2016","journal-title":"Thyroid"},{"issue":"10","key":"key\n\t\t\t\t20181005135538892_B22","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s40618-016-0478-9","article-title":"Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies","volume":"39","author":"Diana","year":"2016","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"key\n\t\t\t\t20181005135538892_B23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000478522","article-title":"Performance and specificity of 6 immunoassays for TSH receptor antibodies: a multicenter study","volume":"6","author":"Diana","year":"2017","journal-title":"Eur Thyroid J"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/cei.12980","article-title":"Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease","volume":"189","author":"Diana","year":"2017","journal-title":"Clin Exp Immunol"},{"issue":"4S","key":"key\n\t\t\t\t20181005135538892_B25","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/IOP.0000000000001053","article-title":"Thyroid stimulating hormone receptor antibodies in thyroid eye disease-methodology and clinical applications","volume":"34","author":"Diana","year":"2018","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-2249.2010.04266.x","article-title":"Novel chimeric thyroid-stimulating hormone-receptor bioassay for thyroid-stimulating immunoglobulins","volume":"162","author":"Lytton","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"key\n\t\t\t\t20181005135538892_B27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1087057111426901","article-title":"A homogeneous fluorescent assay for cAMP-phosphodiesterase enzyme activity","volume":"17","author":"Tian","year":"2012","journal-title":"J Biomol Screen"},{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2003.10.012","article-title":"Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012","volume":"36","author":"Daiber","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"key\n\t\t\t\t20181005135538892_B29","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/1087057112468765","article-title":"Rapid and specific measurements of superoxide using fluorescence spectroscopy","volume":"18","author":"Nazarewicz","year":"2013","journal-title":"J Biomol Screen"},{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B30","doi-asserted-by":"crossref","first-page":"C413","DOI":"10.1152\/ajpcell.00188.2006","article-title":"Analysis of DHE-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems","volume":"292","author":"Fernandes","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"8","key":"key\n\t\t\t\t20181005135538892_B31","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1089\/ars.2007.1969","article-title":"First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction","volume":"10","author":"Wenzel","year":"2008","journal-title":"Antioxid Redox Signal"},{"issue":"12","key":"key\n\t\t\t\t20181005135538892_B32","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1210\/en.2008-0836","article-title":"A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism","volume":"149","author":"Neumann","year":"2008","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20181005135538892_B33","doi-asserted-by":"crossref","first-page":"136810","DOI":"10.1155\/2015\/136810","article-title":"Abnormal expression of DNA double-strand breaks related genes, ATM and GammaH2AX, in thyroid carcinoma","volume":"2015","author":"Hu","year":"2015","journal-title":"Int J Endocrinol"},{"issue":"12","key":"key\n\t\t\t\t20181005135538892_B34","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1158\/1535-7163.MCT-11-0534","article-title":"Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM\/ATR damage response in cancer cells","volume":"10","author":"Berdelle","year":"2011","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH oxidases: an overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell Mol Immunol"},{"issue":"1-2","key":"key\n\t\t\t\t20181005135538892_B36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cccn.2003.10.028","article-title":"Supplementation with antioxidants in the treatment of Graves\u2019 disease; the effect on glutathione peroxidase activity and concentration of selenium","volume":"341","author":"Vrca","year":"2004","journal-title":"Clin Chim Acta"},{"issue":"1","key":"key\n\t\t\t\t20181005135538892_B37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1677\/joe.0.1550151","article-title":"Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues","volume":"155","author":"Venditti","year":"1997","journal-title":"J Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/10\/3668\/25902853\/jc.2018-00509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T20:35:25Z","timestamp":1661718925000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/10\/3668\/5066516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,8,6]]},"published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-00509","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10]]},"published":{"date-parts":[[2018,8,6]]}}}