{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:40:27Z","timestamp":1785307227227,"version":"3.55.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context and Objectives<\/jats:title>\n                  <jats:p>Upper and lower body adipose tissue (AT) exhibits opposing associations with obesity-related cardiometabolic diseases. Recent studies have suggested that altered AT oxygen tension (pO2) may contribute to AT dysfunction. Here, we compared in vivo abdominal (ABD) and femoral (FEM) subcutaneous AT pO2 in women who are overweight and have obesity, and investigated the effects of physiological AT pO2 on human adipocyte function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>ABD and FEM subcutaneous AT pO2 and AT blood flow (ATBF) were assessed in eight [BMI (body mass index) 34.4 \u00b1 1.6 kg\/m2] postmenopausal women who were overweight with obesity and impaired glucose metabolism. ABD and FEM AT biopsy specimens were collected to determine adipocyte morphology and AT gene expression. Moreover, the effects of prolonged exposure (14 days) to physiological AT pO2 on adipokine expression\/secretion, mitochondrial respiration, and glucose uptake were investigated in differentiated human multipotent adipose-derived stem cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AT pO2 was higher in ABD than FEM AT (62.7 \u00b1 6.6 vs 50.0 \u00b1 4.5 mm Hg, P = 0.013), whereas ATBF was comparable between depots. Maximal uncoupled oxygen consumption rates were substantially lower in ABD than FEM adipocytes for all pO2 conditions. Low physiological pO2 (5% O2) decreased proinflammatory gene expression, increased basal glucose uptake, and altered adipokine secretion in ABD and FEM adipocytes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We demonstrated for the first time, to our knowledge, that AT pO2 is higher in ABD than FEM subcutaneous AT in women who are overweight\/with obesity, partly due to a lower oxygen consumption rate in ABD adipocytes. Moreover, low physiological pO2 decreased proinflammatory gene expression and improved the metabolic phenotype in differentiated human adipocytes, whereas more heterogeneous effects on adipokine secretion were found.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-00547","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T18:01:42Z","timestamp":1531850502000},"page":"3688-3697","source":"Crossref","is-referenced-by-count":25,"title":["Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans"],"prefix":"10.1210","volume":"103","author":[{"given":"Max A A","family":"Vogel","sequence":"first","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W E","family":"Jocken","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Sell","sequence":"additional","affiliation":[{"name":"Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hoebers","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Essers","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper M A","family":"Rouschop","sequence":"additional","affiliation":[{"name":"Maastricht Radiation Oncology (MaastRO) Laboratory, GROW\u2014School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merima","family":"\u010cajlakovi\u0107","sequence":"additional","affiliation":[{"name":"Joanneum Research Forschungsgesellschaft mbH, MATERIALS\u2014Institute for Surface Technologies and Photonic, Sensors and Functional Printing, Weiz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen E","family":"Blaak","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs H","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"issue":"2","key":"2020071621281240200_B1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","article-title":"The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance","volume":"94","author":"Goossens","year":"2008","journal-title":"Physiol Behav"},{"key":"2020071621281240200_B2","doi-asserted-by":"crossref","unstructured":"Goossens\n              GH\n            , BlaakEE. Adipose tissue dysfunction and impaired metabolic health in human obesity: a matter of oxygen? 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Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women [published online ahead of print 23 April 2018]. 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