{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:25:25Z","timestamp":1785803125743,"version":"3.56.0"},"reference-count":62,"publisher":"The Endocrine Society","issue":"2","funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD089980"],"award-info":[{"award-number":["R01HD089980"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD089980"],"award-info":[{"award-number":["R01HD089980"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1210\/jc.2018-00820","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T18:03:50Z","timestamp":1534442630000},"page":"408-422","source":"Crossref","is-referenced-by-count":35,"title":["IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-0341","authenticated-orcid":false,"given":"Madhulika B","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Western Ontario, London, Ontario, Canada"},{"name":"Department of Biochemistry, University of Western Ontario, London, Ontario, Canada"},{"name":"Children's Health Research Institute, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majida","family":"Abu Shehab","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Nygard","sequence":"additional","affiliation":[{"name":"Biotron Laboratory, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Biggar","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil S","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado"},{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jansson","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003081-200606000-00008","article-title":"Perinatal outcome and later implications of intrauterine growth restriction","volume":"49","author":"Pallotto","year":"2006","journal-title":"Clin Obstet Gynecol"},{"issue":"5691","key":"key\n\t\t\t\t2018122705482104700_B2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.1095292","article-title":"Living with the past: evolution, development, and patterns of disease","volume":"305","author":"Gluckman","year":"2004","journal-title":"Science"},{"issue":"8850","key":"key\n\t\t\t\t2018122705482104700_B3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"key\n\t\t\t\t2018122705482104700_B5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s13224-011-0092-x","article-title":"Placental insufficiency and fetal growth restriction","volume":"61","author":"Krishna","year":"2011","journal-title":"J Obstet Gynaecol India"},{"key":"key\n\t\t\t\t2018122705482104700_B6","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1016\/S0301-2115(03)00179-9","article-title":"Placental insufficiency and its consequences","volume":"110","author":"Gagnon","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1677\/joe.0.1480303","article-title":"Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight","volume":"148","author":"Hills","year":"1996","journal-title":"J Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t2018122705482104700_B8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1210\/en.2012-1962","article-title":"Phosphorylation of IGFBP-1 at discrete sites elicits variable effects on IGF-I receptor autophosphorylation","volume":"154","author":"Abu Shehab","year":"2013","journal-title":"Endocrinology"},{"issue":"3-5","key":"key\n\t\t\t\t2018122705482104700_B9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000184780","article-title":"IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression","volume":"45","author":"Han","year":"1996","journal-title":"Horm Res"},{"issue":"3","key":"key\n\t\t\t\t2018122705482104700_B10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1677\/joe.0.1290459","article-title":"The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight","volume":"129","author":"Wang","year":"1991","journal-title":"J Endocrinol"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1210\/en.2013-1759","article-title":"Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction","volume":"155","author":"Abu Shehab","year":"2014","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2018122705482104700_B12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mce.2015.04.031","article-title":"IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway","volume":"412","author":"Malkani","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/me.2015-1194","article-title":"Hypoxia increases IGFBP-1 phosphorylation mediated by mTOR inhibition","volume":"30","author":"Damerill","year":"2016","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2018122705482104700_B14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mce.2015.12.006","article-title":"Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC","volume":"425","author":"Malkani","year":"2016","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ajpath.2017.09.009","article-title":"Co-localization of insulin-like growth factor binding protein-1, casein kinase-2\u03b2, and mechanistic target of rapamycin in human hepatocellular carcinoma cells as Demonstrated by dual immunofluorescence and in situ proximity ligation assay","volume":"188","author":"Singal","year":"2018","journal-title":"Am J Pathol"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-213X-2-5","article-title":"Mesenchymally-derived insulin-like growth factor 1 provides a paracrine stimulus for trophoblast migration","volume":"2","author":"Lacey","year":"2002","journal-title":"BMC Dev Biol"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B17","first-page":"1894","article-title":"Gestational age-dependent expression of insulin-like growth factor-binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum, and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy","volume":"82","author":"Martina","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B18","first-page":"488","article-title":"Insulin-like growth factor binding protein 1 and human embryonic development during 6\u201310 gestational weeks","volume":"117","author":"Fang","year":"2004","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"key\n\t\t\t\t2018122705482104700_B19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/humupd\/6.5.495","article-title":"Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract","volume":"6","author":"Fowler","year":"2000","journal-title":"Hum Reprod Update"},{"issue":"9","key":"key\n\t\t\t\t2018122705482104700_B20","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1210\/en.2007-0411","article-title":"Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation","volume":"148","author":"Sferruzzi-Perri","year":"2007","journal-title":"Endocrinology"},{"issue":"3","key":"key\n\t\t\t\t2018122705482104700_B21","doi-asserted-by":"crossref","first-page":"E668","DOI":"10.1152\/ajpendo.00320.2006","article-title":"Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term","volume":"292","author":"Sferruzzi-Perri","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2018122705482104700_B22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2017.04.005","article-title":"Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity","volume":"452","author":"Shehab","year":"2017","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t2018122705482104700_B23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/uog.1806","article-title":"Does antenatal identification of small-for-gestational age fetuses significantly improve their outcome","volume":"25","author":"Lindqvist","year":"2005","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pd.2685","article-title":"A model for a new pyramid of prenatal care based on the 11 to 13 weeks\u2019 assessment","volume":"31","author":"Nicolaides","year":"2011","journal-title":"Prenat Diagn"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1701-2163(16)35129-5","article-title":"Screening, diagnosis, and management of intrauterine growth restriction","volume":"34","author":"Lausman","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"issue":"10008","key":"key\n\t\t\t\t2018122705482104700_B26","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/S0140-6736(15)00131-2","article-title":"Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study","volume":"386","author":"Sovio","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/uog.17211","article-title":"Diagnostic accuracy of individual antenatal tools for prediction of small-for-gestational age at birth","volume":"49","author":"Poljak","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/1471-0528.12172","article-title":"Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta-analysis","volume":"120","author":"Conde-Agudelo","year":"2013","journal-title":"BJOG"},{"key":"key\n\t\t\t\t2018122705482104700_B29","doi-asserted-by":"crossref","first-page":"7124186","DOI":"10.1155\/2016\/7124186","article-title":"Increased umbilical cord PAI-1 levels in placental insufficiency are associated with fetal hypoxia and angiogenesis","volume":"2016","author":"Seferovic","year":"2016","journal-title":"Dis Markers"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B30","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/pr100879z","article-title":"Altered liver secretion of vascular regulatory proteins in hypoxic pregnancies stimulate angiogenesis in vitro","volume":"10","author":"Seferovic","year":"2011","journal-title":"J Proteome Res"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B31","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ajog.2009.10.889","article-title":"Defining normal and abnormal fetal growth: promises and challenges","volume":"202","author":"Zhang","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B32","doi-asserted-by":"crossref","first-page":"517.e1","DOI":"10.1016\/j.ajog.2015.11.001","article-title":"The relationship of circulating proteins in early pregnancy with preterm birth","volume":"214","author":"Lynch","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"key\n\t\t\t\t2018122705482104700_B33","doi-asserted-by":"crossref","first-page":"428.e1","DOI":"10.1016\/j.ajog.2013.12.011","article-title":"Association of extremes of prepregnancy BMI with the clinical presentations of preterm birth","volume":"210","author":"Lynch","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"20","key":"key\n\t\t\t\t2018122705482104700_B34","doi-asserted-by":"crossref","first-page":"14406","DOI":"10.1074\/jbc.274.20.14406","article-title":"Inducible expression of protein kinase CK2 in mammalian cells. Evidence for functional specialization of CK2 isoforms","volume":"274","author":"Vilk","year":"1999","journal-title":"J Biol Chem"},{"issue":"5-6","key":"key\n\t\t\t\t2018122705482104700_B35","first-page":"373","article-title":"Regulation of casein kinase II by growth factors: a reevaluation","volume":"40","author":"Litchfield","year":"1994","journal-title":"Cell Mol Biol Res"},{"issue":"8","key":"key\n\t\t\t\t2018122705482104700_B36","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1074\/mcp.M500113-MCP200","article-title":"Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity","volume":"4","author":"Unwin","year":"2005","journal-title":"Mol Cell Proteomics"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1095\/biolreprod.105.043182","article-title":"Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor","volume":"73","author":"Kim","year":"2005","journal-title":"Biol Reprod"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1096-6374(98)80318-3","article-title":"Insulin-like growth factor binding protein-1 binds to placental cytotrophoblast alpha5beta1 integrin and inhibits cytotrophoblast invasion into decidualized endometrial stromal cultures","volume":"8","author":"Irwin","year":"1998","journal-title":"Growth Horm IGF Res"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/molehr\/7.1.79","article-title":"Regulation of IGF bioavailability in pregnancy","volume":"7","author":"Gibson","year":"2001","journal-title":"Mol Hum Reprod"},{"issue":"9","key":"key\n\t\t\t\t2018122705482104700_B40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/molehr\/gah222","article-title":"Posttranslational modifications of decidual IGFBP-1 by steroid hormones in vitro","volume":"11","author":"Kabir-Salmani","year":"2005","journal-title":"Mol Hum Reprod"},{"issue":"12","key":"key\n\t\t\t\t2018122705482104700_B41","first-page":"3520","article-title":"Hormonal regulation of circulating insulin-like growth factor-binding protein-1 phosphorylation status","volume":"80","author":"Westwood","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B42","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0002-9378(82)90254-X","article-title":"Radioimmunoassay of placental protein 12: levels in amniotic fluid, cord blood, and serum of healthy adults, pregnant women, and patients with trophoblastic disease","volume":"144","author":"Rutanen","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2018122705482104700_B43","first-page":"4","article-title":"Regulation and function of insulin-like growth factor-binding protein-1","volume-title":"Proc Soc Exp Biol Med","author":"Lee","year":"1993"},{"key":"key\n\t\t\t\t2018122705482104700_B44","first-page":"70","article-title":"Assays for IGF binding proteins","volume":"124","author":"Rutanen","year":"1991","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"3","key":"key\n\t\t\t\t2018122705482104700_B45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/clinchem\/43.3.523","article-title":"Immunoassay of insulin-like growth factor binding protein-1","volume":"43","author":"Khosravi","year":"1997","journal-title":"Clin Chem"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B46","first-page":"1735","article-title":"The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy","volume":"79","author":"Westwood","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"key\n\t\t\t\t2018122705482104700_B47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0378-3782(97)01867-7","article-title":"Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth","volume":"49","author":"Holmes","year":"1997","journal-title":"Early Hum Dev"},{"issue":"5","key":"key\n\t\t\t\t2018122705482104700_B48","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/0002-9378(94)90150-3","article-title":"The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1","volume":"171","author":"Hills","year":"1994","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B49","first-page":"99","article-title":"Longitudinal study of the maternal insulin-like growth factor system before, during and after pregnancy in relation to fetal and infant weight","volume":"69","author":"Olausson","year":"2008","journal-title":"Horm Res"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B50","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1210\/jcem.87.4.8418","article-title":"A longitudinal analysis of maternal serum insulin-like growth factor I (IGF-I) and total and nonphosphorylated IGF-binding protein-1 in human pregnancies complicated by intrauterine growth restriction","volume":"87","author":"Bhatia","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"key\n\t\t\t\t2018122705482104700_B51","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.ajog.2005.04.015","article-title":"Maternal plasma concentrations of IGF-1, IGFBP-1, and C-peptide in early pregnancy and subsequent risk of gestational diabetes mellitus","volume":"193","author":"Qiu","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"key\n\t\t\t\t2018122705482104700_B52","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3109\/14767058.2012.663834","article-title":"Maternal serum placental growth hormone at 11-13 weeks' gestation in pregnancies delivering small for gestational age neonates","volume":"25","author":"Sifakis","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1096-6374(98)80302-X","article-title":"Phosphoisoforms of insulin-like growth factor binding protein-1 in appropriate-for-gestational-age and small-for-gestational-age fetuses","volume":"8","author":"Iwashita","year":"1998","journal-title":"Growth Horm IGF Res"},{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2337\/diabetes.48.2.321","article-title":"Phosphorylated insulin-like growth factor binding protein 1 is increased in pregnant diabetic subjects","volume":"48","author":"Gibson","year":"1999","journal-title":"Diabetes"},{"issue":"11","key":"key\n\t\t\t\t2018122705482104700_B55","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1093\/humrep\/14.11.2881","article-title":"The role of insulin-like growth factor binding protein-1 phosphoisoforms in pregnancies with impaired placental function identified by doppler ultrasound","volume":"14","author":"Fowler","year":"1999","journal-title":"Hum Reprod"},{"issue":"4","key":"key\n\t\t\t\t2018122705482104700_B56","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1464-5491.2005.01430.x","article-title":"Effect of maternal diabetes on phosphorylation of insulin-like growth factor binding protein-1 in cord serum","volume":"22","author":"Loukovaara","year":"2005","journal-title":"Diabet Med"},{"issue":"10","key":"key\n\t\t\t\t2018122705482104700_B57","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.biocel.2010.06.010","article-title":"Casein kinase II: an attractive target for anti-cancer drug design","volume":"42","author":"Hanif","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"key\n\t\t\t\t2018122705482104700_B58","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00441-010-1068-3","article-title":"Cellular regulators of protein kinase CK2","volume":"342","author":"Montenarh","year":"2010","journal-title":"Cell Tissue Res"},{"issue":"Pt 1","key":"key\n\t\t\t\t2018122705482104700_B59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021469","article-title":"Protein kinase CK2: structure, regulation and role in cellular decisions of life and death","volume":"369","author":"Litchfield","year":"2003","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2018122705482104700_B60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-4615-5371-7_7","article-title":"Protein kinase CK2 (\u201ccasein kinase-2\u201d) and its implication in cell division and proliferation","volume":"3","author":"Pinna","year":"1997","journal-title":"Prog Cell Cycle Res"},{"issue":"Pt 1","key":"key\n\t\t\t\t2018122705482104700_B61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.2007.129676","article-title":"Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth","volume":"582","author":"Roos","year":"2007","journal-title":"J Physiol"},{"issue":"6","key":"key\n\t\t\t\t2018122705482104700_B62","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0002-9440(10)64849-3","article-title":"Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure","volume":"157","author":"Jauniaux","year":"2000","journal-title":"Am J Pathol"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/2\/408\/27286132\/jc.2018-00820.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T21:51:29Z","timestamp":1604785889000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/2\/408\/5075151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,8,16]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-00820","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,8,16]]}}}