{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:58:35Z","timestamp":1784023115337,"version":"3.55.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Understanding the biological rhythms and stress response in sick newborns is important to minimize the negative effects of intensive care. Salivary cortisol has been used as a noninvasive surrogate marker of adrenal function; however, understanding of its control variables is insufficient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the presence of feeding-induced cortisol response and its control variables in newborns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, and Patients<\/jats:title>\n                  <jats:p>Fifty-three newborn infants, who were between 30 and 40 weeks\u2019 corrected age and were on 3-hourly regular oral\/enteral feeding, were recruited between January 2013 and June 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Saliva samples were collected before and 1 hour after regular feeding. Dependence of cortisol levels (adjusted for postnatal age) and their feeding-related elevation on clinical variables was assessed by using generalized estimating equations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher cortisol levels were associated with corrected age \u226537 weeks and saliva samples collected after feeding (both P &amp;lt; 0.001). Oral feeding was associated with a greater feeding-induced cortisol response compared with exclusive enteral feeding (P = 0.034), whereas a prolonged feeding duration (\u226530 minutes) was associated with a reduced cortisol response compared with brief feeding (&amp;lt;30 minutes) (P &amp;lt; 0.001). Gestational age, corrected age, antenatal\/postnatal glucocorticoids, type of milk, and daily feeding volume had no effect on cortisol response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Feeding-induced cortisol response was observed in newborns. The cortisol response was more prominent following oral feeding and was reduced with prolonged feeding. Future studies may investigate whether feeding-induced cortisol response plays a role in the acquisition of adrenal ultradian and diurnal rhythms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-01052","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T19:48:19Z","timestamp":1533325699000},"page":"4450-4455","source":"Crossref","is-referenced-by-count":9,"title":["Feeding-Induced Cortisol Response in Newborn Infants"],"prefix":"10.1210","volume":"103","author":[{"given":"Masahiro","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Centre for Developmental and Cognitive Neuroscience, Department of Paediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Iwata","sequence":"additional","affiliation":[{"name":"Center for Human Development and Family Science, Department of Neonatology and Pediatrics, Nagoya City 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