{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:20:45Z","timestamp":1770286845603,"version":"3.49.0"},"reference-count":74,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01-HD-008737-11"],"award-info":[{"award-number":["Z01-HD-008737-11"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Howard and Georgeanna Jones Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Uterine leiomyomata (fibroids) are prevalent sex hormone\u2012dependent tumors with an altered response to mechanical stress. Ulipristal acetate, a selective progesterone receptor (PR) modulator, significantly reduces fibroid size in patients. However, PR signaling in fibroids and its relationship to mechanical signaling are incompletely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our prior studies revealed that A-kinase anchoring protein 13 (AKAP13) was overexpressed in fibroids and contributed to altered mechanotransduction in fibroids. Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Fibroid samples from patients treated with ulipristal acetate or placebo were examined for AKAP13 expression by using immunohistochemistry. In immortalized uterine fibroid cell lines and COS-7 cells, we observed that AKAP13 increased ligand-dependent PR activation of luciferase reporters and endogenous progesterone-responsive genes for PR-B but not PR-A. Inhibition of ERK reduced activation of PR-dependent signaling by AKAP13, but inhibition of p38 MAPK had no effect. In addition, glutathione S-transferase\u2012binding assays revealed that AKAP13 was bound to PR-B through its carboxyl terminus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These data suggest an intersection of mechanical signaling and PR signaling involving AKAP13 through ERK. Further elucidation of the integration of mechanical and hormonal signaling pathways in fibroids may provide insight into fibroid development and suggest new therapeutic strategies for treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-01216","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T09:00:28Z","timestamp":1537088428000},"page":"970-980","source":"Crossref","is-referenced-by-count":22,"title":["A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells"],"prefix":"10.1210","volume":"104","author":[{"given":"Sinnie Sin Man","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Jorge","sequence":"additional","affiliation":[{"name":"Section on Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minnie","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Britten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Chi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Chang","sequence":"additional","affiliation":[{"name":"Section on Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"},{"name":"Department of OBGYN and Reproductive Science, Mount Sinai School of Medicine, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberlyn Maravet","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"},{"name":"Section on Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"},{"name":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H","family":"Driggers","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H","family":"Segars","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women\u2019s Health Research, Johns Hopkins Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"issue":"1","key":"2020071623084427700_B1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"2020071623084427700_B2","doi-asserted-by":"crossref","first-page":"211.e1","DOI":"10.1016\/j.ajog.2011.12.002","article-title":"The estimated annual cost of uterine leiomyomata in the United States","volume":"206","author":"Cardozo","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"2020071623084427700_B3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.fertnstert.2014.07.008","article-title":"Alternative therapies in management of leiomyomas","volume":"102","author":"Patel","year":"2014","journal-title":"Fertil Steril"},{"issue":"3","key":"2020071623084427700_B4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/1097-4652(2000)9999:999<000::AID-JCP1040>3.0.CO;2-E","article-title":"17-Beta estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a stimulation of protein kinase-dependent pathway","volume":"186","author":"Barbarisi","year":"2001","journal-title":"J Cell Physiol"},{"issue":"6","key":"2020071623084427700_B5","first-page":"2192","article-title":"Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma","volume":"83","author":"Shimomura","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2020071623084427700_B6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/09513590801893315","article-title":"Upregulation of ATP-sensitive potassium channels for estrogen-mediated cell proliferation in human uterine leiomyoma cells","volume":"24","author":"Park","year":"2008","journal-title":"Gynecol Endocrinol"},{"issue":"10","key":"2020071623084427700_B7","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1210\/endo.141.10.7719","article-title":"In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine\/intracrine mechanism","volume":"141","author":"Sumitani","year":"2000","journal-title":"Endocrinology"},{"issue":"3","key":"2020071623084427700_B8","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/1071-5576(94)00053-4","article-title":"Leiomyoma primary cultures have elevated transcriptional response to estrogen compared with autologous myometrial cultures","volume":"2","author":"Andersen","year":"1995","journal-title":"J Soc Gynecol Investig"},{"issue":"8","key":"2020071623084427700_B9","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/humrep\/den087","article-title":"A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells","volume":"23","author":"Di","year":"2008","journal-title":"Hum Reprod"},{"issue":"5","key":"2020071623084427700_B10","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1210\/jc.2008-2093","article-title":"Progestins activate the AKT pathway in leiomyoma cells and promote survival","volume":"94","author":"Hoekstra","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2020071623084427700_B11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.mce.2011.05.044","article-title":"The role of progesterone signaling in the pathogenesis of uterine leiomyoma","volume":"358","author":"Kim","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2020071623084427700_B12","first-page":"293","article-title":"Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone","volume":"82","author":"Matsuo","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2020071623084427700_B13","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1210\/jc.2005-2379","article-title":"A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells","volume":"91","author":"Chen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2020071623084427700_B14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1210\/er.2012-1043","article-title":"Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer","volume":"34","author":"Kim","year":"2013","journal-title":"Endocr Rev"},{"issue":"05","key":"2020071623084427700_B15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-0035-1558451","article-title":"Uterine leiomyoma stem cells: linking progesterone to growth","volume":"33","author":"Bulun","year":"2015","journal-title":"Semin Reprod Med"},{"issue":"2","key":"2020071623084427700_B16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.fertnstert.2010.09.059","article-title":"Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study","volume":"95","author":"Nieman","year":"2011","journal-title":"Fertil Steril"},{"issue":"5","key":"2020071623084427700_B17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJMoa1103182","article-title":"Ulipristal acetate versus placebo for fibroid treatment before surgery","volume":"366","author":"Donnez","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"2020071623084427700_B18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijgo.2009.11.019","article-title":"Improved quality of life is partly explained by fewer symptoms after treatment of fibroids with mifepristone","volume":"109","author":"Feng","year":"2010","journal-title":"Int J Gynaecol Obstet"},{"issue":"8","key":"2020071623084427700_B19","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/humrep\/dep100","article-title":"Mifepristone for treatment of uterine leiomyoma: a prospective randomized placebo controlled trial","volume":"24","author":"Engman","year":"2009","journal-title":"Hum Reprod"},{"issue":"1","key":"2020071623084427700_B20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1479-828X.2008.00931.x","article-title":"Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial","volume":"49","author":"Bagaria","year":"2009","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"6","key":"2020071623084427700_B21","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.fertnstert.2006.11.094","article-title":"A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata","volume":"87","author":"Chwalisz","year":"2007","journal-title":"Fertil Steril"},{"key":"2020071623084427700_B22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cct.2017.02.002","article-title":"Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids","volume":"55","author":"Seitz","year":"2017","journal-title":"Contemp Clin Trials"},{"issue":"5","key":"2020071623084427700_B23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/AOG.0b013e3181705d0e","article-title":"CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial","volume":"111","author":"Levens","year":"2008","journal-title":"Obstet Gynecol"},{"issue":"5","key":"2020071623084427700_B24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMoa1103180","article-title":"Ulipristal acetate versus leuprolide acetate for uterine fibroids","volume":"366","author":"Donnez","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"2020071623084427700_B25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/1933719117728802","article-title":"Ulipristal acetate and extracellular matrix production in human leiomyomas in vivo: a laboratory analysis of a randomized placebo controlled trial","volume":"25","author":"Cox","year":"2018","journal-title":"Reprod Sci"},{"issue":"3","key":"2020071623084427700_B26","first-page":"531","article-title":"Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium","volume":"32","author":"Whitaker","year":"2017","journal-title":"Hum Reprod"},{"issue":"2","key":"2020071623084427700_B27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0037-1599090","article-title":"Recent advances in uterine fibroid etiology","volume":"35","author":"McWilliams","year":"2017","journal-title":"Semin Reprod Med"},{"issue":"9","key":"2020071623084427700_B28","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1002\/jcp.26537","article-title":"Omega-3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells","volume":"233","author":"Islam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"10","key":"2020071623084427700_B29","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.jbiomech.2015.05.013","article-title":"Dynamic and quasi-static mechanical testing for characterization of the viscoelastic properties of human uterine tissue","volume":"48","author":"Omari","year":"2015","journal-title":"J Biomech"},{"issue":"9","key":"2020071623084427700_B30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1177\/1933719114545240","article-title":"Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures","volume":"21","author":"Malik","year":"2014","journal-title":"Reprod Sci"},{"issue":"1","key":"2020071623084427700_B31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.matbio.2011.09.001","article-title":"Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma","volume":"31","author":"Norian","year":"2012","journal-title":"Matrix Biol"},{"issue":"3","key":"2020071623084427700_B32","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.fertnstert.2012.07.255","article-title":"AKAP13 augments progesterone-dependent gene activation in fibroid cells","volume":"98","author":"Jorge","year":"2012","journal-title":"Fertil Steril"},{"issue":"1","key":"2020071623084427700_B33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1530\/REP-09-0260","article-title":"Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy","volume":"139","author":"Shynlova","year":"2010","journal-title":"Reproduction"},{"issue":"9","key":"2020071623084427700_B34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1177\/1933719114542023","article-title":"Mechanical signaling in reproductive tissues: mechanisms and importance","volume":"21","author":"Jorge","year":"2014","journal-title":"Reprod Sci"},{"issue":"1","key":"2020071623084427700_B35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/humupd\/dmx032","article-title":"Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics","volume":"24","author":"Islam","year":"2018","journal-title":"Hum Reprod Update"},{"issue":"06","key":"2020071623084427700_B36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1055\/s-0037-1607268","article-title":"Mechanical signaling and extracellular matrix in uterine fibroids","volume":"35","author":"Rafique","year":"2017","journal-title":"Semin Reprod Med"},{"issue":"31","key":"2020071623084427700_B37","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1038\/onc.2013.362","article-title":"Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease","volume":"33","author":"Cook","year":"2014","journal-title":"Oncogene"},{"issue":"4","key":"2020071623084427700_B38","doi-asserted-by":"crossref","first-page":"474.e1","DOI":"10.1016\/j.ajog.2007.11.057","article-title":"Mechanical homeostasis is altered in uterine leiomyoma","volume":"198","author":"Rogers","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2020071623084427700_B39","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.stem.2015.07.009","article-title":"Rho-signaling-directed YAP\/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells","volume":"17","author":"Ohgushi","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"19","key":"2020071623084427700_B40","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/sj.onc.1201783","article-title":"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action","volume":"16","author":"Rubino","year":"1998","journal-title":"Oncogene"},{"issue":"50","key":"2020071623084427700_B41","doi-asserted-by":"crossref","first-page":"46792","DOI":"10.1074\/jbc.M106927200","article-title":"The proto-oncoprotein Brx activates estrogen receptor \u03b2 by a p38 mitogen-activated protein kinase pathway","volume":"276","author":"Driggers","year":"2001","journal-title":"J Biol Chem"},{"issue":"14","key":"2020071623084427700_B42","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1074\/jbc.M509339200","article-title":"Rho family guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system","volume":"281","author":"Kino","year":"2006","journal-title":"J Biol Chem"},{"issue":"16","key":"2020071623084427700_B43","doi-asserted-by":"crossref","first-page":"12344","DOI":"10.1074\/jbc.M110.106856","article-title":"The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice","volume":"285","author":"Mayers","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"2020071623084427700_B44","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.fertnstert.2006.08.111","article-title":"Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays","volume":"87","author":"Malik","year":"2007","journal-title":"Fertil Steril"},{"issue":"3","key":"2020071623084427700_B45","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2265.2008.03207.x","article-title":"Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells","volume":"69","author":"Malik","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2020071623084427700_B46","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/humrep\/12.4.815","article-title":"Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium","volume":"12","author":"Viville","year":"1997","journal-title":"Hum Reprod"},{"issue":"23","key":"2020071623084427700_B47","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/jnci\/djs438","article-title":"Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues","volume":"104","author":"Neumeister","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"2020071623084427700_B48","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1006\/bbrc.1993.1525","article-title":"Progesterone induced expression of alkaline phosphatase is associated with a secretory phenotype in T47D breast cancer cells","volume":"192","author":"Dilorenzo","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"issue":"16","key":"2020071623084427700_B49","first-page":"4470","article-title":"Progestin regulation of alkaline phosphatase in the human breast cancer cell line T47D","volume":"51","author":"Di Lorenzo","year":"1991","journal-title":"Cancer Res"},{"issue":"6508","key":"2020071623084427700_B50","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis","volume":"372","author":"Lee","year":"1994","journal-title":"Nature"},{"issue":"23","key":"2020071623084427700_B51","doi-asserted-by":"crossref","first-page":"13585","DOI":"10.1074\/jbc.270.23.13585","article-title":"Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor","volume":"270","author":"Pang","year":"1995","journal-title":"J Biol Chem"},{"issue":"11","key":"2020071623084427700_B52","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/diabetes.49.11.1783","article-title":"Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes","volume":"49","author":"Kayali","year":"2000","journal-title":"Diabetes"},{"issue":"4","key":"2020071623084427700_B53","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1586\/eem.10.3","article-title":"Brx: a link between osmotic stress, inflammation and organ physiology and pathophysiology","volume":"5","author":"Kino","year":"2010","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"57","key":"2020071623084427700_B54","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.2000081","article-title":"Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5","volume":"2","author":"Kino","year":"2009","journal-title":"Sci Signal"},{"issue":"6","key":"2020071623084427700_B55","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0968-0004(01)01800-X","article-title":"Nuclear-receptor interactions on DNA-response elements","volume":"26","author":"Khorasanizadeh","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"2020071623084427700_B56","doi-asserted-by":"crossref","first-page":"e009","DOI":"10.1621\/nrs.07009","article-title":"Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression","volume":"7","author":"Scarpin","year":"2009","journal-title":"Nucl Recept Signal"},{"issue":"9","key":"2020071623084427700_B57","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1091\/mbc.e12-11-0807","article-title":"Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes","volume":"24","author":"Bellance","year":"2013","journal-title":"Mol Biol Cell"},{"issue":"2","key":"2020071623084427700_B58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/mend-2-2-143","article-title":"The MMTV LTR promoter is induced by progesterone and dihydrotestosterone but not by estrogen","volume":"2","author":"Otten","year":"1988","journal-title":"Mol Endocrinol"},{"issue":"2","key":"2020071623084427700_B59","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/mi.10.2.6","article-title":"Networking with AKAPs: context-dependent regulation of anchored enzymes","volume":"10","author":"Welch","year":"2010","journal-title":"Mol Interv"},{"issue":"2","key":"2020071623084427700_B60","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0002-9378(00)70213-4","article-title":"Expression of brx proto-oncogene in normal ovary and in epithelial ovarian neoplasms","volume":"182","author":"Miller","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"2020071623084427700_B61","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1177\/1933719114542019","article-title":"Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells","volume":"21","author":"Ciarmela","year":"2014","journal-title":"Reprod Sci"},{"issue":"5","key":"2020071623084427700_B62","doi-asserted-by":"crossref","first-page":"E775","DOI":"10.1210\/jc.2013-2623","article-title":"Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function","volume":"99","author":"Islam","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2020071623084427700_B63","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/humrep\/del159","article-title":"Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells","volume":"21","author":"Xu","year":"2006","journal-title":"Hum Reprod"},{"issue":"2","key":"2020071623084427700_B64","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jc.2004-1569","article-title":"Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5\u2032-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells","volume":"90","author":"Xu","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2020071623084427700_B65","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1196\/annals.1335.004","article-title":"Mechanisms underlying \u201cfunctional\u201d progesterone withdrawal at parturition","volume":"1034","author":"Brown","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"2020071623084427700_B66","doi-asserted-by":"crossref","first-page":"783289","DOI":"10.1155\/2014\/783289","article-title":"The extracellular matrix contributes to mechanotransduction in uterine fibroids","volume":"2014","author":"Leppert","year":"2014","journal-title":"Obstet Gynecol Int"},{"issue":"1","key":"2020071623084427700_B67","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrm2597","article-title":"Mechanotransduction gone awry","volume":"10","author":"Jaalouk","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2020071623084427700_B68","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the roots of cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"issue":"3","key":"2020071623084427700_B69","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.fertnstert.2017.07.207","article-title":"Synergistic effects of simvastatin and ulipristal acetate on uterine leiomyoma","volume":"108","author":"Malik","year":"2017","journal-title":"Fertil Steril"},{"issue":"1","key":"2020071623084427700_B70","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fertnstert.2014.03.042","article-title":"Liarozole inhibits transforming growth factor-\u03b23\u2012mediated extracellular matrix formation in human three-dimensional leiomyoma cultures","volume":"102","author":"Levy","year":"2014","journal-title":"Fertil Steril"},{"issue":"2","key":"2020071623084427700_B71","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.fertnstert.2014.05.013","article-title":"Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells","volume":"102","author":"Islam","year":"2014","journal-title":"Fertil Steril"},{"issue":"3","key":"2020071623084427700_B72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12079-014-0234-x","article-title":"Matrix production and remodeling as therapeutic targets for uterine leiomyoma","volume":"8","author":"Fujisawa","year":"2014","journal-title":"J Cell Commun Signal"},{"issue":"47","key":"2020071623084427700_B73","doi-asserted-by":"crossref","first-page":"44247","DOI":"10.1074\/jbc.M106629200","article-title":"AKAP-Lbc anchors protein kinase A and nucleates G\u03b112-selective Rho-mediated stress fiber formation","volume":"276","author":"Diviani","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"2020071623084427700_B74","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1194\/jlr.M700171-JLR200","article-title":"Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin","volume":"49","author":"Billon-Denis","year":"2008","journal-title":"J Lipid Res"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/3\/970\/27720955\/jc.2018-01216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/3\/970\/27720955\/jc.2018-01216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:54:34Z","timestamp":1594986874000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/3\/970\/5096790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-01216","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2018,9,14]]}}}