{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:48:59Z","timestamp":1790470139637,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The oral glucose tolerance test (OGTT) is considered the most useful method for diagnosing active acromegaly and for patient follow-up after neurosurgery. Despite its widespread use, only a few small studies have so far focused on patients\u2019 clinical features associated with different GH responsiveness to OGTT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the association between glucose-induced GH response and endocrine profiles, clinical manifestations, and response to therapy in a large cohort of patients with acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>According to GH response to OGTT, patients were grouped as paradoxical (GH-Par) or nonparadoxical (GH-NPar), and their clinical and pathological features were compared in terms of pituitary tumor size, invasiveness, biochemical profiles, and response to therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study concerned 496 patients with acromegaly. At diagnosis, those with GH-Par (n = 184) were older than those with GH-NPar (n = 312) (mean \u00b1 SD, 44.1 \u00b1 13.7 years vs 40.5 \u00b1 12.7 years; P &amp;lt; 0.01) and had smaller tumors (0.82 vs 1.57 cm3; P &amp;lt; 0.01) that less frequently invaded the cavernous sinus (15% vs 27%; P &amp;lt; 0.01). The GH-Par group also had a higher basal GH per volume ratio (14.3 vs 10.5 \u03bcg\/L \u22c5 cm3; P &amp;lt; 0.05) and a lower incidence of hyperprolactinemia (17% vs 30%; P &amp;lt; 0.01) than the GH-NPar group. Importantly, the GH-Par group had a higher rate of remission in response to somatostatin analogues (52% vs 26%; P &amp;lt; 0.01) and a more marked drop in IGF-1 and GH after 6 months of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data strongly suggest that serum GH responsiveness to oral glucose challenge reflects some important biological features of pituitary tumors and that the OGTT may have some prognostic value.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2018-01360","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T18:21:57Z","timestamp":1538590917000},"page":"856-862","source":"Crossref","is-referenced-by-count":33,"title":["Paradoxical GH Increase During OGTT Is Associated With First-Generation Somatostatin Analog Responsiveness in Acromegaly"],"prefix":"10.1210","volume":"104","author":[{"given":"Carla","family":"Scaroni","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Department of Medicine, Padova University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Albiger","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medicine, Padova University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Daniele","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medicine, Padova University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dassie","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Department of Medicine, University of Padova, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Romualdi","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vazza","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Regazzo","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medicine, Padova University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ferra\u00f9","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood \u201cG. 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