{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:52:35Z","timestamp":1791337955260,"version":"4.3.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","funder":[{"DOI":"10.13039\/100005709","name":"Endocrine Society","doi-asserted-by":"publisher","award":["na"],"award-info":[{"award-number":["na"]}],"id":[{"id":"10.13039\/100005709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.1210\/jc.2018-01862","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T20:49:42Z","timestamp":1538167782000},"page":"4097-4103","source":"Crossref","is-referenced-by-count":112,"title":["Cardiovascular and Metabolic Outcomes in Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis"],"prefix":"10.1210","volume":"103","author":[{"given":"Shrikant","family":"Tamhane","sequence":"first","affiliation":[{"name":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Endocrinology, Mayo Clinic, Rochester, Minnesota"},{"name":"Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Rodriguez-Gutierrez","sequence":"additional","affiliation":[{"name":"Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Endocrinology, Hospital Universitario \u201cDr. Jos\u00e9 E. Gonzalez,\u201d Universidad Autonoma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Mohamed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Division of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J","family":"Prokop","sequence":"additional","affiliation":[{"name":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis W","family":"Speiser","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Cohen Children\u2019s Medical Center and Zucker Hofstra Northwell School of Medicine, Lake Success, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5975","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"issue":"2","key":"2019041118365363400_B1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.beem.2008.10.014","article-title":"Genetics of congenital adrenal hyperplasia","volume":"23","author":"Krone","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"9","key":"2019041118365363400_B2","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"95","author":"Speiser","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"2\u20133","key":"2019041118365363400_B3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0925-6164(93)90024-D","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: newborn screening and its relationship to the diagnosis and treatment of the disorder","volume":"2","author":"Pang","year":"1993","journal-title":"Screening"},{"issue":"4 Pt 1","key":"2019041118365363400_B4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1542\/peds.101.4.583","article-title":"Results of screening 1.9 million Texas newborns for 21-hydroxylase-deficient congenital adrenal hyperplasia","volume":"101","author":"Therrell","year":"1998","journal-title":"Pediatrics"},{"issue":"7","key":"2019041118365363400_B5","first-page":"2369","article-title":"Screening for mutations of 21-hydroxylase gene in Hungarian patients with congenital adrenal hyperplasia","volume":"84","author":"Ferenczi","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"10108","key":"2019041118365363400_B6","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/S0140-6736(17)31431-9","article-title":"Congenital adrenal hyperplasia","volume":"390","author":"El-Maouche","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"2019041118365363400_B7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrendo.2013.239","article-title":"Treatment and health outcomes in adults with congenital adrenal hyperplasia","volume":"10","author":"Han","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"2019041118365363400_B8","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"2019041118365363400_B9","unstructured":"Wells G, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2013. www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed 10 September 2017."},{"issue":"3","key":"2019041118365363400_B10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"3","key":"2019041118365363400_B11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.mayocp.2017.01.001","article-title":"Clinical practice guidelines: a primer on development and dissemination","volume":"92","author":"Murad","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"2019041118365363400_B12","unstructured":"Tamhane S, Rodriguez-Gutierrez R, Iqbal AM, Prokop LJ, Bancos I, Speiser PW, Murad MH. Supplemental material. figshare 2018. Deposited 27 August 2018. www.figshare.com\/articles\/CAH_CV_outcomes\/7015106."},{"issue":"6","key":"2019041118365363400_B13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/meta.2000.6261","article-title":"Lipid profile in congenital adrenal hyperplasia","volume":"49","author":"Botero","year":"2000","journal-title":"Metabolism"},{"issue":"5","key":"2019041118365363400_B14","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1210\/jcem.87.5.8456","article-title":"Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications","volume":"87","author":"Charmandari","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041118365363400_B15","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1210\/jc.2006-1711","article-title":"Cardiovascular risk factors and ultrasound evaluation of intima-media thickness at common carotids, carotid bulbs, and femoral and abdominal aorta arteries in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"92","author":"Sartorato","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041118365363400_B16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1210\/jc.2006-1350","article-title":"Metabolic profile and body composition in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"92","author":"Falhammar","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118365363400_B17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000313368","article-title":"Alterations in lipid and carbohydrate metabolism in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"74","author":"Zimmermann","year":"2010","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"2019041118365363400_B18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2265.2009.03587.x","article-title":"Insulin sensitivity and body composition in children with classical and nonclassical congenital adrenal hyperplasia","volume":"72","author":"Williams","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"2019041118365363400_B19","doi-asserted-by":"crossref","first-page":"e24204","DOI":"10.1371\/journal.pone.0024204","article-title":"Adult patients with congenital adrenal hyperplasia have elevated blood pressure but otherwise a normal cardiovascular risk profile","volume":"6","author":"Mooij","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"2019041118365363400_B20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/EJE-10-0877","article-title":"Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"164","author":"Falhammar","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2019041118365363400_B21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1365-2265.2011.04309.x","article-title":"Adolescents with congenital adrenal hyperplasia because of 21-hydroxylase deficiency have vascular dysfunction","volume":"76","author":"Harrington","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2019041118365363400_B22","first-page":"12","article-title":"Increased large artery intima media thickness in adolescents with either classical or non-classical congenital adrenal hyperplasia","volume":"36","author":"Wasniewska","year":"2013","journal-title":"J Endocrinol Invest"},{"issue":"10","key":"2019041118365363400_B23","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s40618-014-0148-8","article-title":"Carotid intima media thickness and other cardiovascular risk factors in children with congenital adrenal hyperplasia","volume":"37","author":"Amr","year":"2014","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"2019041118365363400_B24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/cen.12265","article-title":"Cardiovascular risk factors in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"80","author":"Subbarayan","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2019041118365363400_B25","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1210\/jc.2014-1805","article-title":"Cardiovascular abnormalities and impaired exercise performance in adolescents with congenital adrenal hyperplasia","volume":"100","author":"Marra","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041118365363400_B26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4274\/jcrpe.1658","article-title":"Ambulatory blood pressure and subclinical cardiovascular disease in patients with congenital adrenal hyperplasia: a preliminary report","volume":"7","author":"Aky\u00fcrek","year":"2015","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"11","key":"2019041118365363400_B27","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1210\/jc.2010-0917","article-title":"Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients","volume":"95","author":"Arlt","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2019041118365363400_B28","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1210\/jc.2012-2102","article-title":"Clinical characteristics of a cohort of 244 patients with congenital adrenal hyperplasia","volume":"97","author":"Finkielstain","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041118365363400_B29","doi-asserted-by":"crossref","first-page":"E346","DOI":"10.1210\/jc.2012-3343","article-title":"Genotype-phenotype correlation in 153 adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: analysis of the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE) cohort","volume":"98","author":"Krone","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2019041118365363400_B30","doi-asserted-by":"crossref","first-page":"E1547","DOI":"10.1210\/jc.2014-1486","article-title":"Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE)","volume":"99","author":"Han","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2019041118365363400_B31","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1210\/JC.2015-2093","article-title":"Increased cardiovascular and metabolic morbidity in patients with 21-hydroxylase deficiency: a Swedish population-based national cohort study","volume":"100","author":"Falhammar","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118365363400_B32","doi-asserted-by":"crossref","unstructured":"Bonfig\n              W\n            , RoehlF-W, RiedlS, D\u00f6rrHG, BettendorfM, Br\u00e4mswigJ, Sch\u00f6nauE, RiepeF, HauffaB, HollRW, MohnikeK; AQUAPE CAH Study Group. Blood pressure in a large cohort of children and adolescents with classic adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Am J Hypertens. 2015;29(2):266\u2013272.","DOI":"10.1093\/ajh\/hpv087"},{"issue":"12","key":"2019041118365363400_B33","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1210\/jc.2006-1069","article-title":"Altered 24-hour blood pressure profiles in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"91","author":"V\u00f6lkl","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2019041118365363400_B34","doi-asserted-by":"crossref","first-page":"e44893","DOI":"10.1371\/journal.pone.0044893","article-title":"Impact of glucocorticoid receptor gene polymorphisms on the metabolic profile of adult patients with the classical form of 21-hydroxylase deficiency","volume":"7","author":"Moreira","year":"2012","journal-title":"PLoS ONE"},{"issue":"18","key":"2019041118365363400_B35","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa003417","article-title":"Impact of high-normal blood pressure on the risk of cardiovascular disease","volume":"345","author":"Vasan","year":"2001","journal-title":"N Engl J Med"},{"issue":"5","key":"2019041118365363400_B36","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archinte.1993.00410050036006","article-title":"Blood pressure, systolic and diastolic, and cardiovascular risks. US population data","volume":"153","author":"Stamler","year":"1993","journal-title":"Arch Intern Med"},{"issue":"20","key":"2019041118365363400_B37","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.1996.03530440051036","article-title":"Blood pressure as a cardiovascular risk factor: prevention and treatment","volume":"275","author":"Kannel","year":"1996","journal-title":"JAMA"},{"issue":"26","key":"2019041118365363400_B38","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1056\/NEJM199312233292602","article-title":"The natural history of borderline isolated systolic hypertension","volume":"329","author":"Sagie","year":"1993","journal-title":"N Engl J Med"},{"issue":"8692","key":"2019041118365363400_B39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","article-title":"Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias","volume":"335","author":"MacMahon","year":"1990","journal-title":"Lancet"},{"issue":"1","key":"2019041118365363400_B40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archinte.1992.00400130082009","article-title":"Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease: overall findings and differences by age for 316,099 white men","volume":"152","author":"Neaton","year":"1992","journal-title":"Arch Intern Med"},{"issue":"6","key":"2019041118365363400_B41","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/archdischild-2016-311910","article-title":"Cardiovascular health, growth and gonadal function in children and adolescents with congenital adrenal hyperplasia","volume":"102","author":"Mooij","year":"2017","journal-title":"Arch Dis Child"},{"issue":"3","key":"2019041118365363400_B42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1210\/jc.2014-3809","article-title":"A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia","volume":"100","author":"Mallappa","year":"2015","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/11\/4097\/26109430\/jc.2018-01862.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:36:19Z","timestamp":1555036579000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/11\/4097\/5107761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,9,28]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-01862","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,9,28]]}}}