{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:38:40Z","timestamp":1790818720723,"version":"4.1.0"},"reference-count":31,"publisher":"The Endocrine Society","issue":"6","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/14803-6"],"award-info":[{"award-number":["2016\/14803-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302849\/2015-7"],"award-info":[{"award-number":["302849\/2015-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["153237\/2016-3"],"award-info":[{"award-number":["153237\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301871\/2016-7"],"award-info":[{"award-number":["301871\/2016-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303002\/2016-6"],"award-info":[{"award-number":["303002\/2016-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2014\/1459789"],"award-info":[{"award-number":["2014\/1459789"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1210\/jc.2018-02010","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T16:29:05Z","timestamp":1542644945000},"page":"2112-2120","source":"Crossref","is-referenced-by-count":105,"title":["DLK1 Is a Novel Link Between Reproduction and Metabolism"],"prefix":"10.1210","volume":"104","author":[{"given":"Larissa G","family":"Gomes","sequence":"first","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cunha-Silva","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiane P","family":"Crespo","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina O","family":"Ramos","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana R","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio de Sequenciamento em Larga Escala, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Canton","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lees","sequence":"additional","affiliation":[{"name":"Clinical Genetics Department, Great Ormond Street Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Spoudeas","sequence":"additional","affiliation":[{"name":"Clinical Genetics Department, Great Ormond Street Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Dauber","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Children\u2019s National Health System, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delanie B","family":"Macedo","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S","family":"Bessa","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A","family":"Maciel","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund C","family":"Baracat","sequence":"additional","affiliation":[{"name":"Disciplina de Ginecologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A L","family":"Jorge","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia Gen\u00e9tica (LIM 25), Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B","family":"Mendonca","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio de Sequenciamento em Larga Escala, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius N","family":"Brito","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-693X","authenticated-orcid":false,"given":"Ana Claudia","family":"Latronico","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"issue":"11","key":"2019042414330846700_B1","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.2337\/dc13-0446","article-title":"Age at menarche and type 2 diabetes risk: the EPIC-InterAct study","volume":"36","author":"Elks","year":"2013","journal-title":"Diabetes Care"},{"issue":"3","key":"2019042414330846700_B2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCULATIONAHA.114.010070","article-title":"Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort","volume":"131","author":"Canoy","year":"2015","journal-title":"Circulation"},{"issue":"18","key":"2019042414330846700_B3","doi-asserted-by":"crossref","first-page":"e3580","DOI":"10.1097\/MD.0000000000003580","article-title":"Association between age at menarche and risk factors for cardiovascular diseases in Korean women: the 2010 to 2013 Korea National Health and Nutrition Examination Survey","volume":"95","author":"Won","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"2019042414330846700_B4","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ijo.2012.177","article-title":"Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis","volume":"37","author":"Prentice","year":"2013","journal-title":"Int J Obes"},{"issue":"22","key":"2019042414330846700_B5","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice: precocious puberty","volume":"358","author":"Carel","year":"2008","journal-title":"N Engl J Med"},{"issue":"12","key":"2019042414330846700_B6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrendo.2015.167","article-title":"Molecular insights into the aetiology of female reproductive ageing","volume":"11","author":"Perry","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"2019042414330846700_B7","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ng.3841","article-title":"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk","volume":"49","author":"Day","year":"2017","journal-title":"Nat Genet"},{"issue":"7520","key":"2019042414330846700_B8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13545","article-title":"Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche","volume":"514","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"26","key":"2019042414330846700_B9","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","article-title":"Central precocious puberty caused by mutations in the imprinted gene MKRN3","volume":"368","author":"Abreu","year":"2013","journal-title":"N Engl J Med"},{"issue":"6","key":"2019042414330846700_B10","doi-asserted-by":"crossref","first-page":"E1097","DOI":"10.1210\/jc.2013-3126","article-title":"Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3","volume":"99","author":"Macedo","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019042414330846700_B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-15-0488","article-title":"Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty","volume":"174","author":"Simon","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2019042414330846700_B12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0092-8674(93)90252-L","article-title":"Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation","volume":"73","author":"Smas","year":"1993","journal-title":"Cell"},{"issue":"2","key":"2019042414330846700_B13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"issue":"8","key":"2019042414330846700_B14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/jmg.28.8.511","article-title":"Maternal uniparental disomy for chromosome 14","volume":"28","author":"Temple","year":"1991","journal-title":"J Med Genet"},{"issue":"8","key":"2019042414330846700_B15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/jmedgenet-2014-102396","article-title":"Temple syndrome: improving the recognition of an underdiagnosed chromosome 14 imprinting disorder: an analysis of 51 published cases","volume":"51","author":"Ioannides","year":"2014","journal-title":"J Med Genet"},{"issue":"12","key":"2019042414330846700_B16","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/gim.2017.53","article-title":"Temple syndrome: comprehensive molecular and clinical findings in 32 Japanese patients","volume":"19","author":"Kagami","year":"2017","journal-title":"Genet Med"},{"issue":"4","key":"2019042414330846700_B17","doi-asserted-by":"crossref","first-page":"e36134","DOI":"10.1371\/journal.pone.0036134","article-title":"DLK1 is a somato-dendritic protein expressed in hypothalamic arginine-vasopressin and oxytocin neurons","volume":"7","author":"Villanueva","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"2019042414330846700_B18","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1210\/jc.2016-3677","article-title":"Paternally inherited DLK1 deletion associated with familial central precocious puberty","volume":"102","author":"Dauber","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"15","key":"2019042414330846700_B19","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/MCB.22.15.5585-5592.2002","article-title":"Mice lacking paternally expressed Pref-1\/Dlk1 display growth retardation and accelerated adiposity","volume":"22","author":"Moon","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"18","key":"2019042414330846700_B20","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.1074\/jbc.274.18.12632","article-title":"Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation","volume":"274","author":"Smas","year":"1999","journal-title":"J Biol Chem"},{"issue":"5","key":"2019042414330846700_B21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000446476","article-title":"Two patients with severe short stature due to a FBN1 mutation (p.Ala1728Val) with a mild form of acromicric dysplasia","volume":"86","author":"de Bruin","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"2019042414330846700_B22","unstructured":"The UniProt Consortium. UniProtKB-P80370 (DLK1_HUMAN). Available at:\n          www.uniprot.org\/uniprot\/P80370. Accessed 28 August 2018."},{"issue":"3","key":"2019042414330846700_B23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/humupd\/dmt061","article-title":"Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2019042414330846700_B24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/cen.12319","article-title":"Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades","volume":"80","author":"Lazar","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2019042414330846700_B25","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1210\/me.2009-0160","article-title":"Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate","volume":"23","author":"Sul","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2019042414330846700_B26","doi-asserted-by":"crossref","first-page":"23960","DOI":"10.1038\/srep23960","article-title":"Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells","volume":"6","author":"Rhee","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"2019042414330846700_B27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/humupd\/dmh012","article-title":"Precocious puberty and statural growth","volume":"10","author":"Carel","year":"2004","journal-title":"Hum Reprod Update"},{"key":"2019042414330846700_B28","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"2019042414330846700_B29","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.steroids.2011.12.007","article-title":"Neuroendocrine dysfunction in polycystic ovary syndrome","volume":"77","author":"Burt Solorzano","year":"2012","journal-title":"Steroids"},{"issue":"4","key":"2019042414330846700_B30","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.fertnstert.2008.11.016","article-title":"Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty","volume":"93","author":"Franceschi","year":"2010","journal-title":"Fertil Steril"},{"issue":"3","key":"2019042414330846700_B31","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/EJE-15-0590","article-title":"Management of endocrine disease: long-term outcomes of the treatment of central precocious puberty","volume":"174","author":"Guaraldi","year":"2016","journal-title":"Eur J Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/6\/2112\/28520601\/jc.2018-02010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T14:33:47Z","timestamp":1556116427000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/6\/2112\/5185196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,19]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,11,19]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-02010","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2018,11,19]]}}}