{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:57:36Z","timestamp":1791593856056,"version":"4.3.4"},"reference-count":36,"publisher":"The Endocrine Society","issue":"7","funder":[{"name":"Excellence Of Diabetes Research in Sweden"},{"name":"Swedish Diabetes Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1210\/jc.2018-02165","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T21:15:30Z","timestamp":1548364530000},"page":"2601-2613","source":"Crossref","is-referenced-by-count":32,"title":["Early Changes in Adipose Tissue Morphology, Gene Expression, and Metabolism After RYGB in Patients With Obesity and T2D"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-3372","authenticated-orcid":false,"given":"Petros","family":"Katsogiannos","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5627-8904","authenticated-orcid":false,"given":"Prasad G","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-7625","authenticated-orcid":false,"given":"Gretha J","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Anders","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-7763","authenticated-orcid":false,"given":"Per","family":"Lundkvist","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-2859","authenticated-orcid":false,"given":"Magnus","family":"Sundbom","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-3899","authenticated-orcid":false,"given":"Maria J","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-9481","authenticated-orcid":false,"given":"Jan W","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"issue":"3","key":"2019051808395605200_B1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2337\/diacare.14.3.173","article-title":"Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease","volume":"14","author":"DeFronzo","year":"1991","journal-title":"Diabetes Care"},{"issue":"6","key":"2019051808395605200_B2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/SLA.0000000000001920","article-title":"Substantial decrease in comorbidity 5 years after gastric bypass: a population-based study from the Scandinavian Obesity Surgery Registry","volume":"265","author":"Sundbom","year":"2017","journal-title":"Ann Surg"},{"issue":"6","key":"2019051808395605200_B3","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.soard.2016.05.013","article-title":"Changes of insulin sensitivity and secretion after bariatric\/metabolic surgery","volume":"12","author":"Mingrone","year":"2016","journal-title":"Surg Obes Relat Dis"},{"issue":"8","key":"2019051808395605200_B4","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.soard.2016.03.020","article-title":"Improved glucose metabolism after gastric bypass: evolution of the paradigm","volume":"12","author":"Pournaras","year":"2016","journal-title":"Surg Obes Relat Dis"},{"issue":"5","key":"2019051808395605200_B5","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2337\/db13-1307","article-title":"Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass","volume":"63","author":"Bojsen-M\u00f8ller","year":"2014","journal-title":"Diabetes"},{"issue":"7121","key":"2019051808395605200_B6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"issue":"10","key":"2019051808395605200_B7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"2019051808395605200_B8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/oby.2004.118","article-title":"Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity","volume":"12","author":"Vendrell","year":"2004","journal-title":"Obes Res"},{"issue":"3","key":"2019051808395605200_B9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00125-006-0572-1","article-title":"Fat cell enlargement is an independent marker of insulin resistance and \u2018hyperleptinaemia\u2019","volume":"50","author":"Lundgren","year":"2007","journal-title":"Diabetologia"},{"issue":"1","key":"2019051808395605200_B10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1096\/fj.09-133058","article-title":"Adipocyte size predicts incidence of type 2 diabetes in women","volume":"24","author":"L\u00f6nn","year":"2010","journal-title":"FASEB J"},{"issue":"9","key":"2019051808395605200_B11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/obr.12429","article-title":"Does bariatric surgery improve adipose tissue function","volume":"17","author":"Frikke-Schmidt","year":"2016","journal-title":"Obes Rev"},{"issue":"25","key":"2019051808395605200_B12","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1056\/NEJMoa033179","article-title":"Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease","volume":"350","author":"Klein","year":"2004","journal-title":"N Engl J Med"},{"issue":"2","key":"2019051808395605200_B13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.soard.2011.09.027","article-title":"Omentectomy added to Roux-en-Y gastric bypass surgery: a randomized, controlled trial","volume":"9","author":"Dillard","year":"2013","journal-title":"Surg Obes Relat Dis"},{"issue":"2","key":"2019051808395605200_B14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.gastro.2010.04.056","article-title":"Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults","volume":"139","author":"Fabbrini","year":"2010","journal-title":"Gastroenterology"},{"issue":"7","key":"2019051808395605200_B15","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2337\/dc09-1833","article-title":"Potential additional effect of omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in grade III obese patients undergoing laparoscopic Roux-en-Y gastric bypass: a randomized trial","volume":"33","author":"Herrera","year":"2010","journal-title":"Diabetes Care"},{"issue":"7","key":"2019051808395605200_B16","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2337\/dc13-2395","article-title":"Changes in subcutaneous fat cell volume and insulin sensitivity after weight loss","volume":"37","author":"Andersson","year":"2014","journal-title":"Diabetes Care"},{"issue":"10","key":"2019051808395605200_B17","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/jcem.86.10.7902","article-title":"Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals","volume":"86","author":"Perseghin","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019051808395605200_B18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2012.01.024","article-title":"mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes","volume":"355","author":"Pereira","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2019051808395605200_B19","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1152\/ajplegacy.1971.221.3.850","article-title":"A simple method to determine fat cell size and number in four mammalian species","volume":"221","author":"Di Girolamo","year":"1971","journal-title":"Am J Physiol"},{"issue":"2","key":"2019051808395605200_B20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.mce.2012.10.030","article-title":"The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue","volume":"365","author":"Pereira","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"7196","key":"2019051808395605200_B21","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"2019051808395605200_B22"},{"key":"2019051808395605200_B23","first-page":"e0132335","article-title":"Bariatric surgery for type 2 diabetes mellitus in patients with BMI <30 kg\/m2: a systematic review and meta-analysis","volume-title":"PLoS One","author":"Baskota","year":"2015"},{"issue":"10120","key":"2019051808395605200_B24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(17)33102-1","article-title":"Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial","volume":"391","author":"Lean","year":"2018","journal-title":"Lancet"},{"issue":"8","key":"2019051808395605200_B25","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s00125-011-2193-6","article-title":"Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes","volume":"54","author":"Camastra","year":"2011","journal-title":"Diabetologia"},{"issue":"1","key":"2019051808395605200_B26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11605-009-1060-y","article-title":"Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost","volume":"14","author":"Campos","year":"2010","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"2019051808395605200_B27","doi-asserted-by":"crossref","first-page":"E959","DOI":"10.3390\/ijms18050959","article-title":"Subcutaneous and visceral adipose tissue secretions from extremely obese men and women both acutely suppress muscle insulin signaling","volume":"18","author":"Sarr","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2019051808395605200_B28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ijo.2013.7","article-title":"Permanence of molecular features of obesity in subcutaneous adipose tissue of ex-obese subjects","volume":"37","author":"Cancello","year":"2013","journal-title":"Int J Obes"},{"issue":"7367","key":"2019051808395605200_B29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature10426","article-title":"Dynamics of human adipose lipid turnover in health and metabolic disease","volume":"478","author":"Arner","year":"2011","journal-title":"Nature"},{"issue":"2","key":"2019051808395605200_B30","doi-asserted-by":"crossref","first-page":"E175","DOI":"10.1152\/ajpendo.00044.2017","article-title":"Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: effects of bariatric surgery","volume":"313","author":"Dadson","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"10","key":"2019051808395605200_B31","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s11695-008-9484-0","article-title":"Lipid mobilization following Roux-en-Y gastric bypass examined by magnetic resonance imaging and spectroscopy","volume":"18","author":"Johansson","year":"2008","journal-title":"Obes Surg"},{"issue":"11","key":"2019051808395605200_B32","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/ijo.2016.121","article-title":"Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery","volume":"40","author":"Svane","year":"2016","journal-title":"Int J Obes"},{"issue":"8","key":"2019051808395605200_B33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00018-010-0263-4","article-title":"Adipocyte extracellular matrix composition, dynamics and role in obesity","volume":"67","author":"Mariman","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"2019051808395605200_B34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/dc15-1447","article-title":"Effect of bariatric surgery on adipose tissue glucose metabolism in different depots in patients with or without type 2 diabetes","volume":"39","author":"Dadson","year":"2016","journal-title":"Diabetes Care"},{"issue":"11","key":"2019051808395605200_B35","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.2337\/db10-0585","article-title":"Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss","volume":"59","author":"Divoux","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"2019051808395605200_B36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/jc.2015-3348","article-title":"Accumulation and changes in composition of collagens in subcutaneous adipose tissue after bariatric surgery","volume":"101","author":"Liu","year":"2016","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/7\/2601\/28670930\/jc.2018-02165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T22:37:06Z","timestamp":1662849426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/7\/2601\/5298593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,1,23]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-02165","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,1,23]]}}}