{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:56:37Z","timestamp":1787784997087,"version":"build-2784847793"},"reference-count":48,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009766","name":"Landstinget i V\u00e4rmland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007459","name":"Ragnar S\u00f6derbergs stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1210\/jc.2018-02298","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T14:40:23Z","timestamp":1546526423000},"page":"2031-2040","source":"Crossref","is-referenced-by-count":40,"title":["Sex-Specific Risk of Cardiovascular Disease in Autoimmune Addison Disease\u2014A Population-Based Cohort Study"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-1367","authenticated-orcid":false,"given":"Jakob","family":"Skov","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"K\u00e4mpe","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden"},{"name":"K.G. Jebsen Center for Autoimmune Diseases, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bensing","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"2019041706430245800_B1","author":"Bensing","year":"2016"},{"key":"2019041706430245800_B2","article-title":"Clinical and immunological characteristics of autoimmune Addison\u2019s disease: a nationwide Swedish multicenter study","author":"Dalin","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2019041706430245800_B3","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","article-title":"Premature mortality in patients with Addison\u2019s disease: a population-based study","volume":"91","author":"Bergthorsdottir","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019041706430245800_B4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2265.2008.03340.x","article-title":"Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency","volume":"69","author":"Bensing","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041706430245800_B5","author":"Erichsen","year":"2009"},{"issue":"18","key":"2019041706430245800_B6","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1161\/hc4301.098254","article-title":"Sudden cardiac death in the United States, 1989 to 1998","volume":"104","author":"Zheng","year":"2001","journal-title":"Circulation"},{"issue":"2","key":"2019041706430245800_B7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2265.1995.tb01866.x","article-title":"Plasma catecholamines in patients with Addison\u2019s disease","volume":"42","author":"Bornstein","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2019041706430245800_B8","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1210\/jc.2017-01324","article-title":"Visceral fat and novel biomarkers of cardiovascular disease in patients with Addison\u2019s disease: a case-control study","volume":"102","author":"Bergthorsdottir","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019041706430245800_B9","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1210\/jc.2012-3561","article-title":"Drug prescription patterns in patients with Addison\u2019s disease: a Swedish population-based cohort study","volume":"98","author":"Bj\u00f6rnsdottir","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2019041706430245800_B10","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1210\/jc.2016-2221","article-title":"Exploring inpatient hospitalizations and morbidity in patients with adrenal insufficiency","volume":"101","author":"Stewart","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2019041706430245800_B11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/BF03345773","article-title":"Metabolic and cardiovascular profile in patients with Addison\u2019s disease under conventional glucocorticoid replacement","volume":"32","author":"Giordano","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"2019041706430245800_B12","author":"Walker","year":"2007"},{"issue":"6","key":"2019041706430245800_B13","first-page":"1505","article-title":"Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis","volume":"76","author":"Kerrigan","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041706430245800_B14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1210\/jcem-72-1-39","article-title":"Daily cortisol production rate in man determined by stable isotope dilution\/mass spectrometry","volume":"72","author":"Esteban","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019041706430245800_B15","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1210\/jc.2006-0524","article-title":"The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients","volume":"91","author":"Filipsson","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019041706430245800_B16","doi-asserted-by":"crossref","first-page":"E1938","DOI":"10.1210\/jc.2012-2432","article-title":"Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma","volume":"97","author":"Zueger","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041706430245800_B17","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1210\/jc.2015-1710","article-title":"Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline","volume":"101","author":"Bornstein","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041706430245800_B18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/HYPERTENSIONAHA.113.01060","article-title":"Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study","volume":"62","author":"Savard","year":"2013","journal-title":"Hypertension"},{"issue":"1","key":"2019041706430245800_B19","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish national inpatient register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"issue":"3","key":"2019041706430245800_B20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/intjepid\/29.3.495","article-title":"Comparing Swedish hospital discharge records with death certificates: implications for mortality statistics","volume":"29","author":"Johansson","year":"2000","journal-title":"Int J Epidemiol"},{"key":"2019041706430245800_B21","unstructured":"Skov\n              J\n            \n          , Sundstr\u00f6m A, Ludvigsson JF, K\u00e4mpe O, Bensing S. Data from: Sex-specific risk of cardiovascular disease in autoimmune Addison disease\u2014a population-based cohort study. figshare 2018. Deposited 12 December 2018. https:\/\/dx.doi.org\/10.6084\/m9.figshare.7455014."},{"issue":"6","key":"2019041706430245800_B22","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/cen.13425","article-title":"Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism: a nationwide Danish register-based study","volume":"87","author":"Thvilum","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2019041706430245800_B23","first-page":"2167","article-title":"Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han","year":"2006","journal-title":"J Rheumatol"},{"issue":"16","key":"2019041706430245800_B24","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/CIRCULATIONAHA.116.025961","article-title":"Range of risk factor levels: control, mortality, and cardiovascular outcomes in type 1 diabetes mellitus","volume":"135","author":"Rawshani","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"2019041706430245800_B25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2015.01.027","article-title":"Sex differences in cardiovascular risk factors and disease prevention","volume":"241","author":"Appelman","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2-3","key":"2019041706430245800_B26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaut.2007.02.004","article-title":"The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia","volume":"28","author":"Hahn","year":"2007","journal-title":"J Autoimmun"},{"issue":"12","key":"2019041706430245800_B27","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1210\/jc.2006-1075","article-title":"Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto\u2019s thyroiditis","volume":"91","author":"Taddei","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041706430245800_B28","author":"Chantzichristos","year":"2017"},{"issue":"12","key":"2019041706430245800_B29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJMra1713301","article-title":"Autoimmune polyendocrine syndromes","volume":"378","author":"Husebye","year":"2018","journal-title":"N Engl J Med"},{"issue":"9","key":"2019041706430245800_B30","doi-asserted-by":"crossref","first-page":"e75789","DOI":"10.1371\/journal.pone.0075789","article-title":"Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism: a nationwide register study","volume":"8","author":"Thvilum","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2019041706430245800_B31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/2047487314556004","article-title":"Cardiovascular disease risk in women with premature ovarian insufficiency: a systematic review and meta-analysis","volume":"23","author":"Roeters van Lennep","year":"2016","journal-title":"Eur J Prev Cardiol"},{"issue":"14","key":"2019041706430245800_B32","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJM199909303411401","article-title":"Dehydroepiandrosterone replacement in women with adrenal insufficiency","volume":"341","author":"Arlt","year":"1999","journal-title":"N Engl J Med"},{"issue":"3","key":"2019041706430245800_B33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-2265.2007.02750.x","article-title":"Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status","volume":"66","author":"Christiansen","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2019041706430245800_B34","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1210\/jc.2007-1134","article-title":"Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial","volume":"93","author":"Gurnell","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019041706430245800_B35","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1210\/jc.2008-2636","article-title":"Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial","volume":"94","author":"Rice","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041706430245800_B36","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1210\/jc.2008-1774","article-title":"Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women","volume":"94","author":"Srinivasan","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019041706430245800_B37","doi-asserted-by":"crossref","first-page":"764","DOI":"10.7326\/0003-4819-141-10-200411160-00007","article-title":"Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease","volume":"141","author":"Wei","year":"2004","journal-title":"Ann Intern Med"},{"issue":"8","key":"2019041706430245800_B38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/hrt.2003.020180","article-title":"Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study","volume":"90","author":"Souverein","year":"2004","journal-title":"Heart"},{"issue":"7","key":"2019041706430245800_B39","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1530\/EC-17-0160","article-title":"Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults","volume":"6","author":"Roelfsema","year":"2017","journal-title":"Endocr Connect"},{"issue":"1","key":"2019041706430245800_B40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.beem.2014.08.008","article-title":"Mineralocorticoid substitution and monitoring in primary adrenal insufficiency","volume":"29","author":"Quinkler","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"2019041706430245800_B41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/joim.12162","article-title":"Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency","volume":"275","author":"Husebye","year":"2014","journal-title":"J Intern Med"},{"issue":"12","key":"2019041706430245800_B42","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1210\/jc.2009-1368","article-title":"Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry","volume":"94","author":"Erichsen","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041706430245800_B43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1210\/jc.2017-01928","article-title":"Primary adrenal insufficiency: managing mineralocorticoid replacement therapy","volume":"103","author":"Esposito","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019041706430245800_B44","doi-asserted-by":"crossref","first-page":"F873","DOI":"10.1152\/ajprenal.00109.2017","article-title":"Sex differences in renin-angiotensin-aldosterone system affect extracellular volume in healthy subjects","volume":"314","author":"Toering","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"2019041706430245800_B45","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1523-1755.1999.00260.x","article-title":"Impact of gender on the renal response to angiotensin II","volume":"55","author":"Miller","year":"1999","journal-title":"Kidney Int"},{"issue":"1","key":"2019041706430245800_B46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/cen.12865","article-title":"Incidence of adrenal crisis in patients with adrenal insufficiency","volume":"84","author":"Smans","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2019041706430245800_B47","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12020-017-1441-z","article-title":"Heritability of Addison\u2019s disease and prevalence of associated autoimmunity in a cohort of 112,100 Swedish twins","volume":"58","author":"Skov","year":"2017","journal-title":"Endocrine"},{"issue":"9","key":"2019041706430245800_B48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/014107688808100906","article-title":"Corticosteroid replacement therapy: twice or thrice daily","volume":"81","author":"Groves","year":"1988","journal-title":"J R Soc Med"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/6\/2031\/28476976\/jc.2018-02298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T07:42:08Z","timestamp":1555486928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/6\/2031\/5270381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,1,3]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-02298","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,1,3]]}}}