{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:13:42Z","timestamp":1788592422355,"version":"build-2803163510"},"reference-count":46,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy for postmenopausal breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Case-control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>University teaching hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Patients with postmenopausal breast cancer (n = 20) treated with aromatase inhibitors and 20 age-matched control subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The primary outcome measure was insulin sensitivity index \u2013 Matsuda, derived from a 75-g oral glucose tolerance test. Body composition was assessed by dual energy x-ray absorptiometry and biopsy specimens of subcutaneous adipose tissue obtained for assessment of mRNA transcript levels. Data are reported as mean \u00b1 SEM (patients receiving inhibitors vs control group, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Aromatase inhibitor therapy was associated with significantly lower insulin sensitivity (5.15 \u00b1 0.45 vs 6.80 \u00b1 0.64; P = 0.041), higher peak insulin concentration after oral glucose tolerance test (693.4 \u00b1 78.6 vs 527.6 \u00b1 85.5 pmol\/L; P = 0.035), greater percentage of body fat (38.4% \u00b1 1.0% vs 34.6% \u00b1 1.3%; P = 0.026), and higher plasma leptin concentration (23.5 \u00b1 2.8 vs 15.5 \u00b1 2.3 ng\/mL; P = 0.035).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Women who received aromatase inhibitors for postmenopausal breast cancer had greater percentage body fat and insulin resistance compared with control subjects with no history of breast cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-02339","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T09:10:07Z","timestamp":1553764207000},"page":"3670-3678","source":"Crossref","is-referenced-by-count":35,"title":["Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-6463","authenticated-orcid":false,"given":"Fraser W","family":"Gibb","sequence":"first","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-331X","authenticated-orcid":false,"given":"J Michael","family":"Dixon","sequence":"additional","affiliation":[{"name":"Edinburgh Breast Unit, Western General Hospital, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Clarke","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Western General Hospital, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-2098","authenticated-orcid":false,"given":"Natalie Z","family":"Homer","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M M","family":"Faqehi","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-2994","authenticated-orcid":false,"given":"Ruth","family":"Andrew","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-1648","authenticated-orcid":false,"given":"Brian R","family":"Walker","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen\u2019s Medical Research Institute, Edinburgh, United Kingdom"},{"name":"Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"2019121022401580800_bib1","unstructured":"Health and Social Care Information Centre. 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