{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:18:23Z","timestamp":1788862703369,"version":"build-2803163510"},"reference-count":39,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1210\/jc.2018-02399","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T09:07:42Z","timestamp":1552640862000},"page":"2757-2765","source":"Crossref","is-referenced-by-count":45,"title":["Altered Thyroid Function and Structure in Children and Adolescents Who Are Overweight and Obese: Reversal After Weight Loss"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-2231","authenticated-orcid":false,"given":"Maria Rosaria","family":"Licenziati","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Rehabilitation, Santobono-Pausilipon Children\u2019s Hospital, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Valerio","sequence":"additional","affiliation":[{"name":"Department of Movement Sciences and Wellbeing, University of Naples Parthenope, I-80133, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Vetrani","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Rehabilitation, Santobono-Pausilipon Children\u2019s Hospital, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"De Maria","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Rehabilitation, Santobono-Pausilipon Children\u2019s Hospital, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"Liotta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Rehabilitation, Santobono-Pausilipon Children\u2019s Hospital, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Radetti","sequence":"additional","affiliation":[{"name":"Marienklinik, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"issue":"8","key":"2019052212001140500_B1","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1210\/jc.2006-0095","article-title":"Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids","volume":"91","author":"Reinehr","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019052212001140500_B2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/oby.2001.21","article-title":"Subclinical hypothyroidism in obese patients: relation to resting energy expenditure, serum leptin, body composition, and lipid profile","volume":"9","author":"Tagliaferri","year":"2001","journal-title":"Obes Res"},{"issue":"5","key":"2019052212001140500_B3","first-page":"371","article-title":"Serum concentrations of total T4, T3, reverse T3 and free T4, T3 in moderately obese patients","volume":"39","author":"Chomard","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"issue":"4","key":"2019052212001140500_B4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2796.2000.00737.x","article-title":"Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men","volume":"248","author":"N\u00e4slund","year":"2000","journal-title":"J Intern Med"},{"issue":"4","key":"2019052212001140500_B5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2265.2005.02247.x","article-title":"Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women","volume":"62","author":"Iacobellis","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2019052212001140500_B6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/adc.87.4.320","article-title":"Thyroid hormones before and after weight loss in obesity","volume":"87","author":"Reinehr","year":"2002","journal-title":"Arch Dis Child"},{"issue":"1","key":"2019052212001140500_B7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000063431","article-title":"Thyroid function and obesity in children and adolescents","volume":"54","author":"Stichel","year":"2000","journal-title":"Horm Res"},{"issue":"12","key":"2019052212001140500_B8","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1210\/jc.2008-0823","article-title":"Thyroid function and structure are affected in childhood obesity","volume":"93","author":"Radetti","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019052212001140500_B9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/EJE-10-0288","article-title":"A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity","volume":"163","author":"Rotondi","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2019052212001140500_B10","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019052212001140500_B11","doi-asserted-by":"crossref","first-page":"E827","DOI":"10.1152\/ajpendo.2001.280.6.E827","article-title":"The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation","volume":"280","author":"Fr\u00fchbeck","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"2019052212001140500_B12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1677\/joe.0.1580351","article-title":"The sodium iodide symporter gene and its regulation by cytokines found in autoimmunity","volume":"158","author":"Ajjan","year":"1998","journal-title":"J Endocrinol"},{"issue":"2","key":"2019052212001140500_B13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1210\/endo.139.2.5760","article-title":"Tumor necrosis factor, ceramide, transforming growth factor-beta1, and aging reduce Na+\/I- symporter messenger ribonucleic acid levels in FRTL-5 cells","volume":"139","author":"Pekary","year":"1998","journal-title":"Endocrinology"},{"issue":"4","key":"2019052212001140500_B14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/jir.1997.17.185","article-title":"Tumor necrosis factor-alfa (TNF-alfa) and transforming growth factor-beta1 (TGF-beta1) inhibit the expression and activity of Na+\/K+ATPase in FRTL-5 rat thyroid cells","volume":"17","author":"Pekary","year":"1997","journal-title":"J Interferon Cytokine Res"},{"issue":"20","key":"2019052212001140500_B15","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"issue":"2","key":"2019052212001140500_B16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1365-2265.2003.01836.x","article-title":"The effect of body weight and weight loss on thyroid volume and function in obese women","volume":"59","author":"Sari","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2019052212001140500_B17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF03350300","article-title":"Influences of obesity and weight loss on thyroid hormones: a 3-3.5-year follow-up study on obese subjects with surgical bilio-pancreatic by-pass","volume":"20","author":"Buscemi","year":"1997","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2019052212001140500_B18","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s004310051117","article-title":"Effects of a low-calorie diet on resting metabolic rate and serum tri-iodothyronine levels in obese children","volume":"158","author":"Kiortsis","year":"1999","journal-title":"Eur J Pediatr"},{"issue":"4","key":"2019052212001140500_B19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/ajcn\/46.4.622","article-title":"Effects of exercise and food restriction on body composition and metabolic rate in obese women","volume":"46","author":"Hill","year":"1987","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2019052212001140500_B20","first-page":"281","article-title":"Changes in lifestyle improve body composition, thyroid function, and structure in obese children","volume":"35","author":"Radetti","year":"2012","journal-title":"J Endocrinol Invest"},{"issue":"8","key":"2019052212001140500_B21","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1210\/jc.2008-0476","article-title":"Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children","volume":"93","author":"Cambuli","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2019052212001140500_B22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF03344156","article-title":"Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr)","volume":"29","author":"Cacciari","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"2019052212001140500_B23","volume-title":"Anthropometric Standardization Reference Manual.","author":"Lohman","year":"1988"},{"issue":"5","key":"2019052212001140500_B24","first-page":"709","article-title":"Skinfold equations for estimation of body fatness in children and youth","volume":"60","author":"Slaughter","year":"1988","journal-title":"Hum Biol"},{"issue":"3","key":"2019052212001140500_B25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/adc.51.3.170","article-title":"Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty","volume":"51","author":"Tanner","year":"1976","journal-title":"Arch Dis Child"},{"issue":"9","key":"2019052212001140500_B26","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1097\/HJH.0b013e32832f4f6b","article-title":"Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension","volume":"27","author":"Lurbe","year":"2009","journal-title":"J Hypertens"},{"issue":"1","key":"2019052212001140500_B27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000373881","article-title":"Association of peripheral total and differential leukocyte counts with obesity-related complications in young adults","volume":"8","author":"Yoshimura","year":"2015","journal-title":"Obes Facts"},{"issue":"3","key":"2019052212001140500_B28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/obr.12003","article-title":"Obesity and C-reactive protein in various populations: a systematic review and meta-analysis","volume":"14","author":"Choi","year":"2013","journal-title":"Obes Rev"},{"issue":"1","key":"2019052212001140500_B29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1755-7682-5-2","article-title":"Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population","volume":"5","author":"Imtiaz","year":"2012","journal-title":"Int Arch Med"},{"issue":"1","key":"2019052212001140500_B30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1586\/erc.12.159","article-title":"Neutrophil to lymphocyte ratio and cardiovascular diseases: a\u00a0review","volume":"11","author":"Bhat","year":"2013","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"6","key":"2019052212001140500_B31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.numecd.2016.01.013","article-title":"White blood cell count may identify abnormal cardiometabolic phenotype and preclinical organ damage in overweight\/obese children","volume":"26","author":"Di Bonito","year":"2016","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1","key":"2019052212001140500_B32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2337\/dc11-1456","article-title":"Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children","volume":"35","author":"Di Bonito","year":"2012","journal-title":"Diabetes Care"},{"issue":"7","key":"2019052212001140500_B33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"2","key":"2019052212001140500_B34","first-page":"600","article-title":"Thyroid volume measurement by ultrasound in children as a tool for the assessment of mild iodine deficiency","volume":"79","author":"Vitti","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2019052212001140500_B35"},{"issue":"8","key":"2019052212001140500_B36","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2016-1885","article-title":"Which amount of BMI-SDS reduction is necessary to improve cardiovascular risk factors in overweight children","volume":"101","author":"Reinehr","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019052212001140500_B37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000322075","article-title":"Relationship between thyroid volume and iodine, leptin, and adiponectin in obese women before and after weight loss","volume":"20","author":"Eray","year":"2011","journal-title":"Med Princ Pract"},{"issue":"63","key":"2019052212001140500_B38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.15557\/JoU.2015.0039","article-title":"Ultrasound image of the thyroid gland in obese children","volume":"15","author":"Szczyrski","year":"2015","journal-title":"J Ultrason"},{"issue":"5","key":"2019052212001140500_B39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1365-2796.2009.02090.x","article-title":"Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I","volume":"265","author":"Husebye","year":"2009","journal-title":"J Intern Med"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/7\/2757\/28695419\/jc.2018-02399.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:21:10Z","timestamp":1558531270000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/7\/2757\/5380480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,15]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,3,15]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-02399","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,3,15]]}}}