{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:06:26Z","timestamp":1792317986844,"version":"4.4.0"},"reference-count":57,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1210\/jc.2018-02610","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T09:09:32Z","timestamp":1552036172000},"page":"2911-2924","source":"Crossref","is-referenced-by-count":14,"title":["Individuals With Prediabetes Display Different Age-Related Pathophysiological Characteristics"],"prefix":"10.1210","volume":"104","author":[{"given":"Teresa Vanessa","family":"Fiorentino","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pedace","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Succurro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Perticone","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sciacqua","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perticone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-7688","authenticated-orcid":false,"given":"Giorgio","family":"Sesti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"2019053107202319500_bib1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018","volume":"41","author":"American Diabetes Association","year":"2018","journal-title":"Diabetes Care"},{"issue":"10027","key":"2019053107202319500_bib2","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","article-title":"Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","journal-title":"Lancet"},{"key":"2019053107202319500_bib3","unstructured":"International Diabetes Federation. IDF Diabetes Atlas. 8th ed. International Diabetes Federation, 2017. Online version of IDF Diabetes Atlas available at: www.diabetesatlas.org. Accessed 15 November 2018."},{"key":"2019053107202319500_bib4","author":"Scheen","year":"2005"},{"issue":"6","key":"2019053107202319500_bib5","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2337\/diabetes.52.6.1475","article-title":"The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging","volume":"52","author":"Meigs","year":"2003","journal-title":"Diabetes"},{"issue":"1","key":"2019053107202319500_bib6","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1152\/ajpendo.00366.2002","article-title":"Aging and insulin secretion","volume":"284","author":"Chang","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"2019053107202319500_bib7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2337\/diacare.21.4.518","article-title":"Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994","volume":"21","author":"Harris","year":"1998","journal-title":"Diabetes Care"},{"issue":"12","key":"2019053107202319500_bib8","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1532-5415.1990.tb03449.x","article-title":"Reduced beta-cell secretion and insulin hepatic extraction in healthy elderly subjects","volume":"38","author":"Pacini","year":"1990","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"2019053107202319500_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/jcem-60-1-13","article-title":"Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function","volume":"60","author":"Chen","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2019053107202319500_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"issue":"15","key":"2019053107202319500_bib11","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa1610187","article-title":"Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012","volume":"376","author":"Mayer-Davis","year":"2017","journal-title":"N Engl J Med"},{"issue":"4","key":"2019053107202319500_bib12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jech.2008.080382","article-title":"Trends in the prevalence and incidence of diabetes in the UK: 1996-2005","volume":"63","author":"Gonz\u00e1lez","year":"2009","journal-title":"J Epidemiol Community Health"},{"issue":"11","key":"2019053107202319500_bib13","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJMoa012578","article-title":"Prevalence of impaired glucose tolerance among children and adolescents with marked obesity","volume":"346","author":"Sinha","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"2019053107202319500_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2337\/diacare.29.02.06.dc05-1037","article-title":"Presence of diabetes risk factors in a large U.S. eighth-grade cohort","volume":"29","author":"Baranowski","year":"2006","journal-title":"Diabetes Care"},{"issue":"8","key":"2019053107202319500_bib15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2337\/dc18-0243","article-title":"Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: II. Observations using the oral glucose tolerance test","volume":"41","author":"RISE Consortium","year":"2018","journal-title":"Diabetes Care"},{"issue":"8","key":"2019053107202319500_bib16","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2337\/dc18-0244","article-title":"Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I. Observations using the hyperglycemic clamp","volume":"41","author":"RISE Consortium","year":"2018","journal-title":"Diabetes Care"},{"issue":"3","key":"2019053107202319500_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/dc07-1443","article-title":"Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance","volume":"31","author":"Szoke","year":"2008","journal-title":"Diabetes Care"},{"issue":"10","key":"2019053107202319500_bib18","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2337\/diabetes.48.10.2039","article-title":"Insulin resistance during puberty: results from clamp studies in 357 children","volume":"48","author":"Moran","year":"1999","journal-title":"Diabetes"},{"key":"2019053107202319500_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.atherosclerosis.2016.08.020","article-title":"One-hour post-load hyperglycemia combined with HbA1c identifies pre-diabetic individuals with a higher cardio-metabolic risk burden","volume":"253","author":"Fiorentino","year":"2016","journal-title":"Atherosclerosis"},{"issue":"11","key":"2019053107202319500_bib20","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1210\/jc.2016-1856","article-title":"One-hour postload hyperglycemia confers higher risk of hepatic steatosis to HbA1c-defined prediabetic subjects","volume":"101","author":"Fiorentino","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019053107202319500_bib21","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1210\/jc.2015-2573","article-title":"One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose","volume":"100","author":"Fiorentino","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019053107202319500_bib22","doi-asserted-by":"crossref","first-page":"16753","DOI":"10.1038\/s41598-018-35073-4","article-title":"A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality","volume":"8","author":"Park","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"2019053107202319500_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00125-010-1966-7","article-title":"A novel surrogate index for hepatic insulin resistance","volume":"54","author":"Vangipurapu","year":"2011","journal-title":"Diabetologia"},{"issue":"9","key":"2019053107202319500_bib24","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"issue":"5","key":"2019053107202319500_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/diab.33.5.486","article-title":"C-peptide as a measure of the secretion and hepatic extraction of insulin: pitfalls and limitations","volume":"33","author":"Polonsky","year":"1984","journal-title":"Diabetes"},{"issue":"7","key":"2019053107202319500_bib26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"5","key":"2019053107202319500_bib27","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2337\/db08-1607","article-title":"Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men","volume":"58","author":"Stanc\u00e1kov\u00e1","year":"2009","journal-title":"Diabetes"},{"key":"2019053107202319500_bib28","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.2337\/diabetes.51.2007.S212","article-title":"Accurate assessment of beta-cell function: the hyperbolic correction","volume":"51","author":"Bergman","year":"2002","journal-title":"Diabetes"},{"key":"2019053107202319500_bib29","doi-asserted-by":"crossref","unstructured":"Fiorentino\n              TV\n            , PedaceE, SuccurroE, AndreozziF, PerticoneM, SciacquaA, PerticoneF, SestiG. Supplemental Materials. Data from: Individuals with prediabetes display different age-related pathophysiological characteristics. Figshare repository. Deposited 28 January 2019.","DOI":"10.1210\/jc.2018-02610"},{"issue":"1","key":"2019053107202319500_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S2213-8587(13)70008-1","article-title":"Trajectories of cardiometabolic risk factors before diagnosis of three subtypes of type 2 diabetes: a post-hoc analysis of the longitudinal Whitehall II cohort study","volume":"1","author":"F\u00e6rch","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2019053107202319500_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/jc.2014-2853","article-title":"Relationship between insulin resistance and \u03b2-cell dysfunction in subphenotypes of prediabetes and type 2 diabetes","volume":"100","author":"F\u00e6rch","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019053107202319500_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S2213-8587(18)30051-2","article-title":"Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables","volume":"6","author":"Ahlqvist","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"2019053107202319500_bib33","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S2213-8587(16)00082-6","article-title":"Phenotypes of prediabetes and stratification of cardiometabolic risk","volume":"4","author":"Stefan","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2019053107202319500_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2008.03.021","article-title":"Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes","volume":"135","author":"Kotronen","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"2019053107202319500_bib35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"issue":"12","key":"2019053107202319500_bib36","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa1010949","article-title":"Pioglitazone for diabetes prevention in impaired glucose tolerance","volume":"364","author":"DeFronzo","year":"2011","journal-title":"N Engl J Med"},{"issue":"9701","key":"2019053107202319500_bib37","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(09)61375-1","article-title":"Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study","volume":"374","author":"Astrup","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"2019053107202319500_bib38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJMoa1203858","article-title":"Basal insulin and cardiovascular and other outcomes in dysglycemia","volume":"367","author":"Gerstein","year":"2012","journal-title":"N Engl J Med"},{"issue":"3","key":"2019053107202319500_bib39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1463-1326.2009.01156.x","article-title":"Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db\/db mice","volume":"12","author":"Moritoh","year":"2010","journal-title":"Diabetes Obes Metab"},{"issue":"9","key":"2019053107202319500_bib40","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.2337\/dc11-0291","article-title":"Effects of exenatide on measures of \u03b2-cell function after 3 years in metformin-treated patients with type 2 diabetes","volume":"34","author":"Bunck","year":"2011","journal-title":"Diabetes Care"},{"issue":"1","key":"2019053107202319500_bib41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2337\/dc07-1616","article-title":"Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance","volume":"31","author":"Rosenstock","year":"2008","journal-title":"Diabetes Care"},{"issue":"1","key":"2019053107202319500_bib42","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2337\/dc07-1441","article-title":"The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose","volume":"31","author":"Utzschneider","year":"2008","journal-title":"Diabetes Care"},{"issue":"6","key":"2019053107202319500_bib43","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2337\/dc09-1203","article-title":"Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes","volume":"33","author":"Rosenstock","year":"2010","journal-title":"Diabetes Care"},{"issue":"10","key":"2019053107202319500_bib44","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.2337\/dc13-0354","article-title":"Benefits of liraglutide treatment in overweight and obese older individuals with prediabetes","volume":"36","author":"Kim","year":"2013","journal-title":"Diabetes Care"},{"issue":"9786","key":"2019053107202319500_bib45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(11)60207-9","article-title":"Management of type 2 diabetes: new and future developments in treatment","volume":"378","author":"Tahrani","year":"2011","journal-title":"Lancet"},{"key":"2019053107202319500_bib46","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.2337\/diabetes.51.2007.S134","article-title":"Lipotoxicity in human pancreatic islets and the protective effect of metformin","volume":"51","author":"Lupi","year":"2002","journal-title":"Diabetes"},{"issue":"10","key":"2019053107202319500_bib47","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.2337\/dc05-2445","article-title":"The effect of pioglitazone on the liver: role of adiponectin","volume":"29","author":"Gastaldelli","year":"2006","journal-title":"Diabetes Care"},{"issue":"9","key":"2019053107202319500_bib48","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.2337\/diabetes.51.9.2796","article-title":"Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women","volume":"51","author":"Buchanan","year":"2002","journal-title":"Diabetes"},{"issue":"10","key":"2019053107202319500_bib49","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.2337\/dc08-0577","article-title":"Effect of aging on A1c levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004","volume":"31","author":"Pani","year":"2008","journal-title":"Diabetes Care"},{"key":"2019053107202319500_bib50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.diabres.2017.09.017","article-title":"Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals","volume":"134","author":"Fiorentino","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"45","key":"2019053107202319500_bib51","doi-asserted-by":"crossref","first-page":"79576","DOI":"10.18632\/oncotarget.18572","article-title":"Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction","volume":"8","author":"Fiorentino","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"2019053107202319500_bib52","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1007\/s00125-009-1443-3","article-title":"Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes","volume":"52","author":"Faerch","year":"2009","journal-title":"Diabetologia"},{"issue":"1","key":"2019053107202319500_bib53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/diabetes.50.1.150","article-title":"Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity","volume":"50","author":"Breda","year":"2001","journal-title":"Diabetes"},{"issue":"7","key":"2019053107202319500_bib54","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/jc.2018-00260","article-title":"Older subjects with \u03b2-cell dysfunction have an accentuated incretin release","volume":"103","author":"de Jes\u00fas Garduno-Garcia","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019053107202319500_bib55","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2337\/dc05-2179","article-title":"Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose","volume":"29","author":"Abdul-Ghani","year":"2006","journal-title":"Diabetes Care"},{"issue":"4","key":"2019053107202319500_bib56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.diabet.2012.02.002","article-title":"Estimating insulin secretion in youth using simple indices derived from the oral glucose tolerance test","volume":"38","author":"Henderson","year":"2012","journal-title":"Diabetes Metab"},{"issue":"2","key":"2019053107202319500_bib57","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4239\/wjd.v1.i2.36","article-title":"Surrogate markers of insulin resistance: a review","volume":"1","author":"Singh","year":"2010","journal-title":"World J Diabetes"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/7\/2911\/28751437\/jc.2018-02610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T07:20:47Z","timestamp":1559287247000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/7\/2911\/5371248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,8]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,3,8]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2018-02610","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,3,8]]}}}