{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:51Z","timestamp":1787021211700,"version":"build-2736575974"},"reference-count":42,"publisher":"The Endocrine Society","issue":"12","funder":[{"DOI":"10.13039\/501100009878","name":"Regione del Veneto","doi-asserted-by":"publisher","award":["863\/01\/98"],"award-info":[{"award-number":["863\/01\/98"]}],"id":[{"id":"10.13039\/501100009878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF2011-02352318"],"award-info":[{"award-number":["RF2011-02352318"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Unidustria of Treviso"},{"name":"Fondazione per la Ricerca Cardiovascolare e sull'Ipertensione Arteriosa"},{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"publisher","award":["DOR1670784\/16"],"award-info":[{"award-number":["DOR1670784\/16"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"publisher","award":["DOR1743424\/17"],"award-info":[{"award-number":["DOR1743424\/17"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"publisher","award":["DOR1842303\/18"],"award-info":[{"award-number":["DOR1842303\/18"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"University of Padova","doi-asserted-by":"publisher","award":["BIRD163255\/16"],"award-info":[{"award-number":["BIRD163255\/16"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The G protein\u2013coupled estrogen receptor (GPER) mediates an aldosterone secretagogue effect of 17\u03b2-estradiol in human HAC15 adrenocortical cells after estrogen receptor \u03b2 blockade. Because GPER mediates mineralocorticoid receptor-independent aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its own synthesis via GPER activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HAC15 cells were exposed to aldosterone in the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and\/or of the selective GPER antagonist G36. Aldosterone synthase (CYP11B2) mRNA and protein levels changes were the study end points. Similar experiments were repeated in strips obtained ex vivo from aldosterone-producing adenoma (APA) and in GPER-silenced HAC15 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aldosterone markedly increased CYP11B2 mRNA and protein expression (vs untreated samples, P &lt; 0.001) in both models by acting via GPER, because these effects were abolished by G36 (P &lt; 0.01) and not by canrenone. GPER-silencing (P &lt; 0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis. Angiotensin II potentiated the GPER-mediated effect of aldosterone on CYP11B2. Coimmunoprecipitation studies provided evidence for GPER-angiotensin type-1 receptor heterodimerization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We propose that this autocrine-paracrine mechanism could enhance aldosterone biosynthesis under conditions of immediate physiological need in which the renin-angiotensin-aldosterone system is stimulated as, for example, hypovolemia. Moreover, as APA overexpresses GPER this mechanism could contribute to the aldosterone excess that occurs in primary aldosteronism in a seemingly autonomous fashion from angiotensin II.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2019-00043","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T09:10:08Z","timestamp":1558689008000},"page":"6316-6324","source":"Crossref","is-referenced-by-count":22,"title":["Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism"],"prefix":"10.1210","volume":"104","author":[{"given":"Brasilina","family":"Caroccia","sequence":"first","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Maria","family":"Seccia","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Piazza","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Prisco","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Zanin","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Iacobone","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Lenzini","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Pallafacchina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Padua, Italy"},{"name":"Italian National Research Council (CNR), Neuroscience Institute, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Domening","sequence":"additional","affiliation":[{"name":"Attoquant Diagnostics, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Poglitsch","sequence":"additional","affiliation":[{"name":"Attoquant Diagnostics, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-0931","authenticated-orcid":false,"given":"Gian Paolo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Specialized Center for Blood Pressure Disorders-Regione Veneto and Hypertension Unit, Department of Medicine-DIMED, University of Padua, Padua, 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