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We also tested in a genome-wide association study (GWAS) whether the interindividual variation in OXT serum levels might be explained by genetic variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The OXT concentration was increased in subjects with elevated BMI and positively correlated with WHR, waist circumference, and triglyceride levels. The OXT concentration in subjects with BMI &lt;25 kg\/m2 was significantly lower (n = 256; 78.6 pg\/mL) than in subjects with a BMI between 25 and 30 kg\/m2 (n = 314; 98.5 pg\/mL, P = 6 \u00d7 10\u22126) and with BMI &gt;30 kg\/m2 (n = 137; 106.4 pg\/mL, P = 8 \u00d7 10\u22126). OXT levels were also positively correlated with plasma glucose and insulin and were elevated in subjects with impaired glucose tolerance (P = 4.6 \u00d7 10\u22123). Heritability of OXT was estimated at 12.8%. In a GWAS, two hits in linkage disequilibrium close (19 kb) to the OXT reached genome-wide significant association (top-hit rs12625893, P = 3.1 \u00d7 10\u22128, explained variance 3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show that OXT is genetically affected by a variant near OXT and is associated with obesity and impaired glucose tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2019-00643","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:48:10Z","timestamp":1565203690000},"page":"5621-5632","source":"Crossref","is-referenced-by-count":26,"title":["Circulating Oxytocin Is Genetically Determined and Associated With Obesity and Impaired Glucose Tolerance"],"prefix":"10.1210","volume":"104","author":[{"given":"Mark Florian Joachim","family":"Weingarten","sequence":"first","affiliation":[{"name":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical 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