{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:25:12Z","timestamp":1782537912801,"version":"3.54.5"},"reference-count":26,"publisher":"The Endocrine Society","issue":"10","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context\/Objective<\/jats:title>\n                  <jats:p>Increased PTH after successful parathyroid surgery represents a clinical conundrum. We aimed to determine the prevalence of persistently elevated PTH (PePTH) postsurgery, along with predisposing factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>and Setting: Patients \u2265 age 18 with parathyroidectomy performed at University of North Carolina Hospitals for primary hyperparathyroidism (PHPT) over a 12-year period were identified from the Carolina Data Warehouse. Clinical and demographic characteristics were collected, transformed, and analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five hundred seventy patients met initial criteria for PHPT, and of those 407 had postoperative values. One hundred forty-four had laboratory results within 3 to 18 months post operatively. There was no clinical difference between those with and without long-term laboratory follow-up. Presurgery, patients had average calcium of 11 mg\/dL and PTH 125.4 pg\/mL. Ninety-seven percent of patients had normalized calcium after surgery, but 30% had PePTH, which can be predicted at 3 months. Patients with PePTH (persistent elevation of PTH) after surgery did not differ from those with normalized PTH in terms of sex, age, body mass index, or excised gland weight; presurgery 25-vitamin D was slightly lower, but not abnormal (26 \u00b1 15 vs 36 \u00b1 11). The presurgical PTH was significantly higher (P &amp;lt; 0.001) in those with PePTH (156.5 pg\/mL compared with presurgical level of 102.5 in those whose PTH normalized).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Nearly one-third of PHPT patients have elevated PTH levels postsurgery in a tertiary hospital setting. At presentation, patients with PePTH tend to have higher PTH relative to calcium levels. Whether PePTH after surgical treatment of PHPT has pathological consequences is unknown.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2019-00705","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:11:20Z","timestamp":1560345080000},"page":"4473-4480","source":"Crossref","is-referenced-by-count":41,"title":["Persistently Elevated PTH After Parathyroidectomy at One Year: Experience in a Tertiary Referral Center"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-0490","authenticated-orcid":false,"given":"Marie","family":"Caldwell","sequence":"first","affiliation":[{"name":"Department of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Laux","sequence":"additional","affiliation":[{"name":"NC TraCS Institute, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Clark","sequence":"additional","affiliation":[{"name":"NC TraCS Institute, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-8667","authenticated-orcid":false,"given":"Janet","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina, Chapel Hill, North 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