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Haptoglobin (Hp), a protein with functional genetic polymorphisms, has antioxidant, anti-inflammatory, and angiogenic effects. Among people with diabetes, the Hp 2-2 phenotype is associated with cardiorenal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether Hp phenotype is associated with PE in type 1 diabetes mellitus (T1DM) and\/or modulates lipoprotein-associated risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>Multicenter prospective study of T1DM pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Pregnant women with T1DM (normal albuminuria, normotensive at enrolment, n = 47) studied at three visits, all preceding PE onset: 12.3 \u00b1 1.9, 21.8 \u00b1 1.5, and 31.5 \u00b1 1.6 weeks\u2019 gestation (mean \u00b1 SD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Hp phenotype and lipoprotein profiles in women with (n = 23) vs without (n = 24) subsequent PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hp phenotype did not predict PE, but lipoprotein associations with subsequent PE were confined to women with Hp 2-2, in whom the following associations with PE were observed: increased low-density lipoprotein (LDL) cholesterol, LDL particle concentration, apolipoprotein B (APOB), triacylglycerol\/high-density lipoprotein (HDL) cholesterol ratio, and APOB\/apolipoprotein AI (APOA1) ratio; decreased HDL cholesterol, APOA1, large HDL particle concentration, and peripheral lipoprotein lipolysis (all P &lt; 0.05). In women with one or two Hp-1 alleles, no such associations were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In women with T1DM, although Hp phenotype did not predict PE risk, lipoprotein-related risks for PE were limited to those with the Hp 2-2 phenotype. Hp phenotype may modulate PE risk in diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2019-00723","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T13:16:46Z","timestamp":1561036606000},"page":"4743-4755","source":"Crossref","is-referenced-by-count":11,"title":["Haptoglobin Phenotype Modulates Lipoprotein-Associated Risk for Preeclampsia in Women With Type 1 Diabetes"],"prefix":"10.1210","volume":"104","author":[{"given":"Clare B","family":"Kelly","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy Y","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia J","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina"},{"name":"NHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison J","family":"Nankervis","sequence":"additional","affiliation":[{"name":"Diabetes Service, Royal Women\u2019s Hospital, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian F","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish K","family":"Garg","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Scardo","sequence":"additional","affiliation":[{"name":"Spartanburg Regional Medical Center, Spartanburg, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar M","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E","family":"Aston","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-1622","authenticated-orcid":false,"given":"Timothy J","family":"Lyons","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"issue":"10","key":"2019091012212715700_bib1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/clinchem\/42.10.1589","article-title":"Biological and clinical significance of haptoglobin polymorphism in humans","volume":"42","author":"Langlois","year":"1996","journal-title":"Clin Chem"},{"issue":"2","key":"2019091012212715700_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/ars.2009.2793","article-title":"Haptoglobin: basic and clinical aspects","volume":"12","author":"Levy","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"2019091012212715700_bib3","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins","volume":"121","author":"Schaer","year":"2013","journal-title":"Blood"},{"issue":"17","key":"2019091012212715700_bib4","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1093\/nar\/11.17.5811","article-title":"Sequence of human haptoglobin cDNA: evidence that the \u03b1 and \u03b2 subunits are coded by the same mRNA","volume":"11","author":"Raugei","year":"1983","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2019091012212715700_bib5","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1520\/JFS11232J","article-title":"Distributions of genetic markers in United States populations: III. 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