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Clinical factors independently associated with HP disorders included HP radiotherapy (at any dose for GHD, TSHD, LH\/FSHD, &amp;gt;30 Gy for ACTHD), alkylating agents (GHD, LH\/FSHD), intrathecal chemotherapy (GHD), hydrocephalus with shunt placement (GHD, LH\/FSHD), seizures (TSHD, ACTHD), and stroke (GHD, TSHD, LH\/FSHD, ACTHD). Adverse health outcomes independently associated with HP disorders included short stature (GHD, TSHD), severe bone mineral density deficit (GHD, LH\/FSHD), obesity (LH\/FSHD), frailty (GHD), impaired physical health-related quality of life (TSHD), sexual dysfunction (LH\/FSHD), impaired memory, and processing speed (GHD, TSHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HP radiotherapy, central nervous system injury, and, to a lesser extent, chemotherapy are associated with HP disorders, which are associated with adverse health outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2019-00834","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:34:54Z","timestamp":1565350494000},"page":"6101-6115","source":"Crossref","is-referenced-by-count":76,"title":["Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-Term Health Outcomes"],"prefix":"10.1210","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-2336","authenticated-orcid":false,"given":"Laura","family":"van Iersel","sequence":"first","affiliation":[{"name":"Division of Endocrinology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"},{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deo Kumar","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M","family":"Brinkman","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee"},{"name":"Department of Psychology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari L","family":"Bjornard","sequence":"first","affiliation":[{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen L","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Green","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee"},{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Merchant","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hon","family":"Pui","sequence":"first","affiliation":[{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Howell","sequence":"first","affiliation":[{"name":"Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, 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