{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:55:28Z","timestamp":1790294128998,"version":"4.1.0"},"reference-count":8,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Psychogenic adipsic hypernatremia is an exceedingly rare and life-threatening condition, occurring in those with severe psychiatric disorders. Its diagnosis requires exclusion of congenital or acquired hypothalamic pathologic entities. We present the case of a patient who experienced transient severe hypernatremia without evidence of brain pathologic features or known psychiatric disease. In our patient, the transient adipsic hypernatremia had resulted from an episode of mild depression that resolved spontaneously.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Description<\/jats:title>\n                  <jats:p>A 46-year-old healthy woman who had had three recurrent admissions within 1 month had presented for evaluation of intractable nausea and vomiting with a history of a recent episode of a depressive mood change. Each admission had shown substantial hypernatremia (maximum plasma sodium, 166 mEq\/L) accompanied by a strong aversion to consuming water. The findings from the diagnostic evaluation showed elevated serum osmolality and lower than expected urine osmolality (urine osmolality range, 474\u2013501 mOsm\/kg). This finding, along with an MRI scan showing the presence of a normal posterior pituitary bright spot, suggested that the osmoregulation of her thirst and arginine vasopressin (AVP) secretion were both defective during the attack. The patient was evaluated by psychiatry. Mild depression was diagnosed, and the patient started treatment with mirtazapine, which she only took for a few days. The patient\u2019s hypernatremia had completely recovered with resolution of her depression within 2 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A mild mood disorder can cause transient dysregulation of the thirst mechanism and AVP secretion through not yet identified mechanisms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2019-01446","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:44:52Z","timestamp":1565189092000},"page":"5427-5430","source":"Crossref","is-referenced-by-count":6,"title":["Hypernatremic Hydrophobic Transient Adipsia Without Organic or Severe Psychiatric Disorder"],"prefix":"10.1210","volume":"104","author":[{"given":"Aleida","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Division of Endocrinology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois"},{"name":"Division of Endocrinology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-7879","authenticated-orcid":false,"given":"Leon","family":"Fogelfeld","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois"},{"name":"Division of Endocrinology, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"2019100118015783300_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/978-1-4471-1817-6_30","article-title":"Disorders of thirst in man","volume-title":"Thirst: Physiological and Psychological Aspects","author":"Robertson","year":"1991"},{"issue":"7","key":"2019100118015783300_bib2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJM198608143150706","article-title":"Hypodipsic hypernatremia with normal osmoregulation of vasopressin","volume":"315","author":"Hammond","year":"1986","journal-title":"N Engl J Med"},{"issue":"6","key":"2019100118015783300_bib3","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1001\/archinte.1986.00360180234035","article-title":"Severe hypernatremia in a patient with psychiatric illness","volume":"146","author":"Farley","year":"1986","journal-title":"Arch Intern Med"},{"issue":"12","key":"2019100118015783300_bib4","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/ndt\/gfh479","article-title":"The dilemma of diagnosing the cause of hypernatraemia: drinking habits vs diabetes insipidus","volume":"19","author":"Workeneh","year":"2004","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"2019100118015783300_bib5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0272-6386(12)80531-2","article-title":"Psychogenic adipsia in a patient with psychotic depression","volume":"15","author":"Phillips","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"2019100118015783300_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.12688\/f1000research.9181.1","article-title":"Case report: severe hypernatremia from psychogenic adipsia","volume":"6","author":"Manning","year":"2017","journal-title":"F1000Res"},{"issue":"4","key":"2019100118015783300_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.0953-8194.2004.01183.x","article-title":"Magnetic resonance imaging of the hypothalamic-neurohypophyseal system","volume":"16","author":"Fujisawa","year":"2004","journal-title":"J Neuroendocrinol"},{"issue":"14","key":"2019100118015783300_bib8","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1073\/pnas.1403382111","article-title":"Regional brain responses associated with drinking water during thirst and after its satiation","volume":"111","author":"Saker","year":"2014","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/jc.2019-01446\/29025981\/jc.2019-01446.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/104\/11\/5427\/30094261\/jc.2019-01446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T18:02:23Z","timestamp":1569952943000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/104\/11\/5427\/5542341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2019-01446","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,8,2]]}}}