{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:33:00Z","timestamp":1773153180564,"version":"3.50.1"},"reference-count":26,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have recently demonstrated that a competitive antagonist of GHRH, (N-Ac-Tyr1,d-Arg2)GHRH-(1\u201329)NH2 (GHRH-Ant), eliminates nearly all nocturnal GH pulsatility in normal subjects, supporting the hypothesis that GH pulsatility is driven by GHRH. In this study, we compared the effects of every 12 h iv boluses of either GHRH-Ant or saline on 24-h GH profiles in a patient with acromegaly due to a metastatic GHRH-secreting carcinoid tumor. Bolus doses of GHRH-Ant (400 \u03bcg\/kg, iv) acutely suppressed GH concentration to 30\u201340% of the pretreatment baseline, and this effect lasted 3\u20134 h. Administration of GHRH (0.33 \u03bcg\/kg, iv) bolus resulted in a small rise in GH, and this effect was blocked by GHRH-Ant (400\u03bc g\/kg). During saline treatment, the secretory patterns of both GH and ectopic GHRH were pulsatile; however, there was no correlation between changes in plasma GHRH and GH concentrations. This lack of correlation was probably due to the majority of circulating GHRH immunoreactivity consisting of nonbiologically active GHRH fragments. These data support the hypothesis that GH hypersecretion in the ectopic GHRH syndrome requires GHRH receptor occupancy and validates the use of GHRH-Ant to probe the potential involvement of endogenous GHRH in patients with acromegaly due to pituitary somatotropinoma.<\/jats:p>","DOI":"10.1210\/jcem.82.2.3772","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:00:51Z","timestamp":1389200451000},"page":"634-637","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of Growth Hormone (GH) Hypersecretion due to Ectopic GH-Releasing Hormone (GHRH) by a Selective GHRH Antagonist*"],"prefix":"10.1210","volume":"82","author":[{"given":"Craig A.","family":"Jaffe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Divisions of Endocrinology and Metabolism (C.A.J., R.D.-F., A.L.B), Department of Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"DeMott-Friberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Endocrinology and Metabolism (C.A.J., R.D.-F., A.L.B), Department of Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Frohman","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, University of Illinois (L.A.F.), Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel L.","family":"Barkan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Endocrinology and Metabolism (C.A.J., R.D.-F., A.L.B), Department of Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071615132986900_R1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1126\/science.2864742","article-title":"Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat.","volume":"230","author":"Plotsky","year":"1985","journal-title":"Science"},{"key":"2020071615132986900_R2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1172\/JCI114681","article-title":"Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep.","volume":"86","author":"Frohman","year":"1991","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R3","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/endo-128-2-1151","article-title":"Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes.","volume":"128","author":"Thomas","year":"1991","journal-title":"Endocrinology"},{"key":"2020071615132986900_R4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/BF03347767","article-title":"Relationship between hypophyseal portal GHRH and somatostatin and peripheral GH levels in conscious sheep.","volume":"17","author":"Cataldi","year":"1994","journal-title":"J Endocrinol Invest"},{"key":"2020071615132986900_R5","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1172\/JCI111864","article-title":"Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1\u201340).","volume":"75","author":"Vance","year":"1985","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R6","first-page":"1403","article-title":"Persistence of rapid growth hormone (GH) pulsatility after successful removal of GH-producing pituitary tumors.","volume":"78","author":"Ho","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615132986900_R7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI116639","article-title":"Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GHRH) antagonist: direct evidence for involvement of endogenous GHRH in the generation of GH pulses.","volume":"92","author":"Jaffe","year":"1993","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1210\/jcem-63-5-1057","article-title":"Acromegaly due to ectopic growth hormone (GH)-releasing hormone (GHRH) production: dynamic studies of GH and ectopic GHRH secretion.","volume":"63","author":"Barkan","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615132986900_R9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0076-6879(86)24029-X","article-title":"Measurement of growth hormone-releasing factor.","volume":"124","author":"Frohman","year":"1986","journal-title":"Methods Enzymol"},{"key":"2020071615132986900_R10","first-page":"E486","article-title":"Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection","volume":"250","author":"Veldhuis","year":"1986","journal-title":"Am J Physiol."},{"key":"2020071615132986900_R11","author":"Diggle","year":"1990"},{"key":"2020071615132986900_R12","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/endo-115-5-1952","article-title":"The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion.","volume":"115","author":"Tannenbaum","year":"1984","journal-title":"Endocrinology"},{"key":"2020071615132986900_R13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1210\/jcem-68-2-499","article-title":"Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion.","volume":"68","author":"Moller","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615132986900_R14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0002-9343(85)90559-5","article-title":"Growth hormone secretion dynamics in a patient with ectopic growth hormone-releasing factor production.","volume":"79","author":"Ch\u2019ng","year":"1985","journal-title":"Am J Med"},{"key":"2020071615132986900_R15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1172\/JCI111333","article-title":"Metabolic clearance and plasma disappearance rates of human pancreatic tumor growth hormone releasing factor in man.","volume":"73","author":"Frohman","year":"1984","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1210\/jcem-62-3-591","article-title":"Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH.","volume":"62","author":"Vance","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615132986900_R17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1172\/JCI112679","article-title":"Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.","volume":"78","author":"Frohman","year":"1986","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R18","author":"Frohman","year":"1987"},{"key":"2020071615132986900_R19","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1172\/JCI118516","article-title":"Endogenous growth hormone-releasing hormone is required for GH responses to pharmacological stimuli.","volume":"97","author":"Jaffe","year":"1996","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/acta.0.1160049","article-title":"Plasma growth hormone in acromegalic patients: demonstration of highly reproducible diurnal profiles in individual patients.","volume":"116","author":"Christensen","year":"1987","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2020071615132986900_R21"},{"key":"2020071615132986900_R22","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI117890","article-title":"Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia.","volume":"95","author":"Arnold","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071615132986900_R23","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJM199004053221405","article-title":"Acromegaly.","volume":"322","year":"1990","journal-title":"N Engl J Med"},{"key":"2020071615132986900_R24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1210\/jcem-58-5-796","article-title":"A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor.","volume":"58","author":"Asa","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615132986900_R25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2265.1989.tb02229.x","article-title":"Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma.","volume":"30","author":"Bevan","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071615132986900_R26","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1210\/endo.131.5.1425411","article-title":"Pituitary adenomas in mice transgenic for growth hormone-releasing hormone.","volume":"131","author":"Asa","year":"1992","journal-title":"Endocrinology"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/82\/2\/634\/10903695\/jcem0634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/82\/2\/634\/10903695\/jcem0634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:32:25Z","timestamp":1594953145000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/82\/2\/634\/2823515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.82.2.3772","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2,1]]}}}