{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T09:41:54Z","timestamp":1649065314857},"reference-count":29,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pituitary-adrenal activity has been found to be inhibited during early nocturnal sleep in humans. This inhibition was supposed to reflect a regulatory influence of hippocampal cells characterized by the expression of mineralocorticoid receptors (MR). Pituitary adrenal responsiveness to bolus injections of CRH (50 \u03bcg) was examined in each of nine healthy men on four occasions: CRH was injected either during early nocturnal sleep or at the same time of night while the subject was kept awake. Both of these conditions were run after pretreatment with the selective MR antagonist, canrenoate (2 \u00d7 200 mg, 0800 and 1700 h, preceding the experimental night) and after placebo administration. After placebo, sleep reduced ACTH and cortisol secretory responses to CRH to about 65% of the size observed during wakefulness (P &amp;lt; 0.05). After canrenoate, ACTH and cortisol secretory responses during sleep and wakefulness did not differ and were comparable with those obtained in placebo-treated subjects during wakefulness. Compared with placebo, canrenoate also distinctly reduced the time spent in slow-wave sleep (P &amp;lt; 0.005). The findings confirm an inhibition of pituitary-adrenal responsiveness during early sleep. The inhibition disappearance after blockage of MR suggests that sleep exerts this influence via central nervous MR-expressing cells. These cells seem to be simultaneously involved in the generation of slow-wave sleep.<\/jats:p>","DOI":"10.1210\/jcem.82.4.3856","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:01:48Z","timestamp":1389200508000},"page":"1106-1110","source":"Crossref","is-referenced-by-count":0,"title":["Blocking of Central Nervous Mineralocorticoid Receptors Counteracts Inhibition of Pituitary-Adrenal Activity in Human Sleep*"],"prefix":"10.1210","volume":"82","author":[{"given":"Jan","family":"Born","sequence":"first","affiliation":[{"name":"Clinical Neuroendocrinology (J.B., D.S., H.-L.F.), 23538 Lu\u0308beck, Germany"},{"name":"Physiological Psychology (J.B.), University of Bamberg, 96045 Bamberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology (J.B., D.S., H.-L.F.), 23538 Lu\u0308beck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Dodt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (C.D., H.-L.F.), University of Lu\u0308beck, 23538 Lu\u0308beck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst-Lorenz","family":"Fehm","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology (J.B., D.S., H.-L.F.), 23538 Lu\u0308beck, Germany"},{"name":"Department of Internal Medicine (C.D., H.-L.F.), University of Lu\u0308beck, 23538 Lu\u0308beck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071622281428700_R1","author":"Van Cauter","year":"1995"},{"key":"2020071622281428700_R2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1210\/jcem-38-6-1018","article-title":"Effects of a prolonged 3-hour sleep-wake cycle on sleep stages, plasma cortisol, growth hormone and body temperature in man.","volume":"38","author":"Weitzman","year":"1974","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622281428700_R3","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1172\/JCI115396","article-title":"Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.","volume":"88","author":"Van Cauter","year":"1991","journal-title":"J Clin Invest"},{"key":"2020071622281428700_R4","first-page":"683","article-title":"Effects of diurnal sleep on secretion of cortisol, luteinizing hormone, and growth hormone in man.","volume":"78","author":"Pietrowsky","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622281428700_R5"},{"key":"2020071622281428700_R6","first-page":"1170","article-title":"Corticotropin-releasing-hormone induced ACTH and cortisol secretion depends on sleep and wakefulness.","volume":"77","author":"Spa\u0308th-Schwalbe","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622281428700_R7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1159\/000126793","article-title":"Sleep and wakefulness affect the responsiveness of the pituitary-adrenocortical axis to arginine vasopressin in humans.","volume":"60","author":"Spa\u0308th-Schwalbe","year":"1994","journal-title":"Neuroendocrinology"},{"key":"2020071622281428700_R8","first-page":"95","article-title":"Brain corticosteroid receptor balance and homeostatic control.","volume":"12","year":"1991","journal-title":"Front Neuroendocrinol"},{"key":"2020071622281428700_R9","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1210\/endo-124-6-2844","article-title":"Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors.","volume":"124","author":"Dallman","year":"1989","journal-title":"Endocrinology"},{"key":"2020071622281428700_R10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000124766","article-title":"Differential response of type 1 and type 2 corticosteroid receptors to change to plasma steroid level and circadian rhythmicity.","volume":"45","author":"Reul","year":"1987","journal-title":"Neuroendocrinology"},{"key":"2020071622281428700_R11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(94)90014-0","article-title":"Mineralocorticoid and glucocorticoid receptors in the brain. 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