{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:47:59Z","timestamp":1763747279293,"version":"3.40.4"},"reference-count":36,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the present study was to examine the effect of changes in plasma osmolality (pOsm) on the responses of the pituitary-adrenal axis to CRH and atrial natriuretic peptide (ANP) release in patients with central diabetes insipidus (DI). Eight normal subjects and six DI patients were subjected to human CRH (hCRH) (1 \u03bcg\/kg) stimulation alone or associated with isotonic volume loading (0.9% NaCl, 12 mL\u00b7kg\u00b760 min) or an osmotic stimulus (5% NaCl, 0.06 mL\u00b7kg\/min\u00b7120 min). The DI group showed significantly increased pOsm and undetectable or low plasma arginine vasopressin (AVP) during all tests. In the control group, pOsm and plasma AVP increased only during the osmotic stimulus. The DI group presented lower plasma ANP levels than controls during osmotic stimulus and isotonic volume loading. The lower ANP secretion in DI patients corroborates the importance of neurohypophyseal hormones in ANP regulation. Basal plasma ACTH and cortisol levels did not differ between controls and DI. The latter group presented a higher ACTH response than controls during stimulation with hCRH alone [area under the curve (AUC) 1138 \u00b1 99 vs. 709 \u00b1 62 pmol\u00b7L\/min] and hCRH\/5% NaCl (AUC 1602 \u00b1 209 vs. 1158 \u00b1 187 pmol\u00b7L\u00b7min). The DI cortisol AUC were higher than controls during stimulation with hCRH alone (65,471 \u00b1 6,070 vs. 48,062 \u00b1 3,476 nmol\u00b7L\u00b7min) and hCRH\/5% NaCl (89,005 \u00b1 10,043 vs. 62,105 \u00b1 5,600 nmol\u00b7L\u00b7min). The highest ACTH and cortisol responses to hCRH in both groups were obtained with hCRH\/5% NaCl. There was a significant correlation between mean pOsm and ACTH response to hCRH (r = 0.62). The increased responses to hCRH with increasing pOsm were present in control subjects and in patients with DI. However, at any given level of pOsm, there was no difference in ACTH response between controls and DI. These data indicate that the acute increases in pOsm augmented the ACTH and cortisol responses to hCRH that involve other factors besides magnocellular AVP.<\/jats:p>","DOI":"10.1210\/jcem.82.4.3884","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:01:48Z","timestamp":1389200508000},"page":"1243-1247","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Plasma Osmolality on Pituitary-Adrenal Responses to Corticotropin-Releasing Hormone and Atrial Natriuretic Peptide Changes in Central Diabetes Insipidus*"],"prefix":"10.1210","volume":"82","author":[{"given":"Lucila L. K.","family":"Elias","sequence":"first","affiliation":[{"name":"Endocrinology Division, Department of Medicine (L.L.K.E., P.C.L.E., A.C.M.), Ribeira\u0303o Preto, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u0301","family":"Antunes-Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Physiology (J.A.R.), Faculty of Medicine, 14049\u2013900, Ribeira\u0303o Preto, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula C. L.","family":"Elias","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Medicine (L.L.K.E., P.C.L.E., A.C.M.), Ribeira\u0303o Preto, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrton C.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Medicine (L.L.K.E., P.C.L.E., A.C.M.), Ribeira\u0303o Preto, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071618581714300_R1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","article-title":"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and \u03b2-endorphin.","volume":"213","author":"Vale","year":"1981","journal-title":"Science"},{"key":"2020071618581714300_R2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1152\/physrev.1988.68.3.743","article-title":"Factors involved in the 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Physiol."},{"key":"2020071618581714300_R15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1749-6632.1993.tb55565.x","article-title":"Interactions between vasopressin and atrial natriuretic peptides.","volume":"689","author":"Thrasher","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"2020071618581714300_R16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1159\/000124878","article-title":"Atrial natriuretic peptide in the median eminence is of paraventricular nucleus origin.","volume":"46","author":"Palkovits","year":"1987","journal-title":"Neuroendocrinology"},{"key":"2020071618581714300_R17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2826.1990.tb00386.x","article-title":"Atrial natriuretic factor is released into hypophysial portal blood: direct evidence that atrial natriuretic factor may be a neurohormone involved in hypothalamic pituitary control.","volume":"2","author":"Lim","year":"1990","journal-title":"J 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secretion.","volume":"73","author":"Miller","year":"1970","journal-title":"Ann Int Med"},{"key":"2020071618581714300_R21","first-page":"19","article-title":"Standardization of a radioimmunoassay for plasma ACTH.","volume":"31","author":"Moreira","year":"1987","journal-title":"Arq Bras Endocrinol Metab"},{"year":"1977","author":"Vieira","key":"2020071618581714300_R22"},{"year":"1979","author":"Glick","key":"2020071618581714300_R23"},{"key":"2020071618581714300_R24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0006-291X(84)80370-8","article-title":"Atrial natriuretic factor is a circulating hormone.","volume":"30","author":"Gutkowska","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071618581714300_R25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/eje.0.1300121","article-title":"Enhanced adrenocorticotrophic hormone and cortisol responses to corticotrophin-releasing hormone in central diabetes 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