{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:01:32Z","timestamp":1773860492471,"version":"3.50.1"},"reference-count":22,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of gonadotropins, androgens, and insulin in the regulation of circulating leptin levels is obscure. In order to clarify the relationships of these parameters we studied serum leptin levels in 19 healthy control subjects and in 35 hyperandrogenic and hyperinsulinemic patients with polycystic ovary syndrome (PCOS).<\/jats:p>\n               <jats:p>Serum leptin concentrations did not differ significantly between PCOS patients and control subjects. When PCOS and control groups were analyzed together by univariate analysis, serum leptin was positively correlated with body mass index (BMI), body weight, serum insulin, serum triglyceride, and serum free testosterone concentrations. Serum leptin was inversely correlated with serum sex hormone binding globulin (SHBG) concentrations. There were no significant correlations between serum leptin and testosterone, androstenedione, or gonadotropin concentrations. Serum insulin, triglyceride, and free testosterone concentrations were positively correlated, and serum SHBG was negatively correlated with BMI. However, when BMI on one hand and serum insulin, triglyceride, free testosterone, or SHBG on other hand were used as independent variables in the partial correlation analysis with leptin, BMI turned out to be the variable primarily responsible for all of the correlations with leptin.<\/jats:p>\n               <jats:p>In conclusion, the concept that circulating leptin levels would be different in PCOS patients than in regularly menstruating control subjects is not supported by our data.<\/jats:p>","DOI":"10.1210\/jcem.82.6.3996","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:01:43Z","timestamp":1389200503000},"page":"1697-1700","source":"Crossref","is-referenced-by-count":106,"title":["Serum Leptin Concentrations in Women with Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"82","author":[{"given":"Juha","family":"Rouru","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology (J.R., R.H., M.K.), University of Turku"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Anttila","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (L.A., T.P.), Turku University Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pertti","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry (P.K., K.I.), Turku University Central Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula-Anneli","family":"Penttila\u0308","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (L.A., T.P.), Turku University Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerttu","family":"Irjala","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry (P.K., K.I.), Turku University Central Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto","family":"Huupponen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology (J.R., R.H., M.K.), University of Turku"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Koulu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology (J.R., R.H., M.K.), University of Turku"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071613345976200_R1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue.","volume":"327","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"2020071613345976200_R2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice.","volume":"269","author":"Peleymounter","year":"1995","journal-title":"Science"},{"key":"2020071613345976200_R3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene.","volume":"269","author":"Halaas","year":"1995","journal-title":"Science"},{"key":"2020071613345976200_R4","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks.","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"key":"2020071613345976200_R5","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2337\/diab.45.11.1455","article-title":"Leptin: The tale of an obesity gene.","volume":"45","author":"Caro","year":"1996","journal-title":"Diabetes"},{"key":"2020071613345976200_R6","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1210\/endo.137.7.8770941","article-title":"Leptin is a metabolic signal to the reproductive system.","volume":"137","author":"Barash","year":"1996","journal-title":"Endocrinology"},{"key":"2020071613345976200_R7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans.","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"2020071613345976200_R8","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2337\/diab.45.7.988","article-title":"Relationship between insulin sensitivity and plasma leptin concentration in lean and obese 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free testosterone in polycystic ovary syndrome measured with a new reference method.","volume":"65","author":"Penttila\u0308","year":"1996","journal-title":"Fertil Steril"},{"key":"2020071613345976200_R14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/bmj.293.6543.355","article-title":"Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.","volume":"293","author":"Adams","year":"1986","journal-title":"Br Med J"},{"key":"2020071613345976200_R15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.","volume":"1","author":"Maffei","year":"1995","journal-title":"Nat Med"},{"key":"2020071613345976200_R16","first-page":"4166","article-title":"Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome.","volume":"81","author":"Brzechffa","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613345976200_R17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2337\/diab.45.5.699","article-title":"Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro.","volume":"45","author":"Kolaczynski","year":"1996","journal-title":"Diabetes"},{"key":"2020071613345976200_R18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2337\/diab.45.5.695","article-title":"Plasma leptin and insulin relationships in obese and nonobese humans.","volume":"45","author":"Dagogo-Jack","year":"1996","journal-title":"Diabetes"},{"key":"2020071613345976200_R19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF00403921","article-title":"Insulin increases plasma leptin concentrations in normal subjects and patients with 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