{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:35:10Z","timestamp":1693344910839},"reference-count":26,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcitriol acts via its receptor (VDR) and inhibits PTH secretion and parathyroid cell proliferation. Increased prevalence of the polymorphic VDR alleles b, a, and T has been demonstrated in sporadic primary hyperparathyroidism. Sixty-two patients with primary hyperparathyroidism due to parathyroid adenoma (mean age, 69.5 \u00b1 1.4 yr) were genotyped for these VDR polymorphisms. Dispersed cells of the adenomas were exposed to increasing concentrations of extracellular Ca2+ and analyzed for PTH release and cytoplasmic Ca2+ concentrations. Ca2+-mediated PTH inhibition exhibited higher ED50 and less suppression in the cells of patients who were homozygous for the b, a, and T alleles (P &amp;lt; 0.05\u20130.10). When analyzing haplotypes, the patients with baT demonstrated a ED50 of 1.81 \u00b1 0.15 vs. 1.29 \u00b1 0.10 for BAt (P &amp;lt; 0.05). As VDR alleles were unrelated to parathyroid intracellular Ca2+, influences of polymorphic VDR alleles on PTH secretion seem to involve mechanisms other than the Ca2+-sensing protein of the parathyroid cell surface.<\/jats:p>","DOI":"10.1210\/jcem.82.6.4012","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:01:43Z","timestamp":1389200503000},"page":"1772-1775","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D Receptor Polymorphisms Correlate to Parathyroid Cell Function in Primary Hyperparathyroidism1"],"prefix":"10.1210","volume":"82","author":[{"given":"Tobias","family":"Carling","sequence":"first","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ridefelt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hellman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go\u0308ran","family":"A\u030akerstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071613521447900_R1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2362.1988.tb01163.x","article-title":"Prevalence of hypercalcemia in a health survey: a fourteen-year follow-up study of serum calcium values.","volume":"18","author":"Palme\u0301r","year":"1988","journal-title":"Eur J Clin Invest"},{"key":"2020071613521447900_R2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0039-6060(97)90357-3","article-title":"Health screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women.","volume":"121","author":"Lundgren","year":"1997","journal-title":"Surgery"},{"key":"2020071613521447900_R3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1210\/jcem-56-3-572","article-title":"Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue.","volume":"56","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613521447900_R4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1677\/joe.0.1160457","article-title":"Relationship between external and cytoplasmic calcium concentrations, parathyroid hormone release and weight of parathyroid glands in human hyperparathyroidism.","volume":"116","author":"Wallfelt","year":"1988","journal-title":"J Endocrinol"},{"key":"2020071613521447900_R5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.","volume":"366","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"2020071613521447900_R6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/BF01116888","article-title":"Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism.","volume":"4","author":"Larsson","year":"1984","journal-title":"Biosci Rep"},{"key":"2020071613521447900_R7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI111696","article-title":"Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells.","volume":"75","author":"LeBoff","year":"1985","journal-title":"J Clin Invest"},{"key":"2020071613521447900_R8","first-page":"3107","article-title":"Mutational analysis of the extracellular Ca2+-sensing receptor gene in human parathyroid tumors.","volume":"80","author":"Hosokawa","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613521447900_R9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF02555137","article-title":"1,25(OH)2D3 inhibits hormone secretion and proliferation but not functional dedifferentiation of cultured bovine parathyroid cells.","volume":"43","author":"Nygren","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"2020071613521447900_R10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1210\/endo-125-2-935","article-title":"Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells.","volume":"125","author":"Kremer","year":"1989","journal-title":"Endocrinology"},{"key":"2020071613521447900_R11","first-page":"175","article-title":"Regulation of parathyroid hormone synthesis and secretion.","volume":"14","author":"Silver","year":"1994","journal-title":"Semin Nephrol"},{"key":"2020071613521447900_R12","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1073\/pnas.89.17.8097","article-title":"Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.","volume":"89","author":"Demay","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071613521447900_R13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1677\/joe.0.1230137","article-title":"Effects of 1,25-dihydroxyvitamin D3 and cortisol on bovine and human parathyroid cells.","volume":"123","author":"Karmali","year":"1989","journal-title":"J Endocrinol"},{"key":"2020071613521447900_R14","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1172\/JCI116720","article-title":"Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients.","volume":"92","author":"Fukuda","year":"1993","journal-title":"J Clin Invest"},{"key":"2020071613521447900_R15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/367284a0","article-title":"Prediction of bone density from vitamin D receptor alleles.","volume":"367","author":"Morrison","year":"1994","journal-title":"Nature"},{"key":"2020071613521447900_R16","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1172\/JCI117568","article-title":"Bone mineral density in relation to polymorphism at the vitamin D receptor locus.","volume":"94","author":"Hustmyer","year":"1994","journal-title":"J Clin Invest"},{"key":"2020071613521447900_R17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/nm1295-1309","article-title":"Vitamin D receptor genotypes in primary hyperparathyroidism.","volume":"1","author":"Carling","year":"1995","journal-title":"Nat Med"},{"key":"2020071613521447900_R18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/bbrc.1997.6086","article-title":"Vitamin D receptor alleles b, a and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1.","volume":"231","author":"Carling","year":"1997","journal-title":"Biochem and Biophys Res Commun"},{"key":"2020071613521447900_R19"},{"key":"2020071613521447900_R20","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jbmr.5650100622","article-title":"The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women.","volume":"10","author":"Riggs","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2020071613521447900_R21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0303-7207(92)90161-X","article-title":"Neomycin interacts with Ca2+ sensing of normal and adenomatous parathyroid cells.","volume":"83","author":"Ridefelt","year":"1992","journal-title":"Mol Cell Endocrinol"},{"key":"2020071613521447900_R22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1530\/acta.0.1020543","article-title":"Discrimination between intact and mid C-regional PTH using selective radioimmunoassay systems.","volume":"102","author":"Ju\u0308ppner","year":"1983","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2020071613521447900_R23","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1016\/S0021-9258(18)61172-X","article-title":"Rapid mobilization of cellular Ca2+ in bovine parathyroid cells evoked by extracellular divalent cations.","volume":"262","author":"Nemeth","year":"1987","journal-title":"J Biol Chem"},{"key":"2020071613521447900_R24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1210\/endo.136.2.7835282","article-title":"Calcium receptor messenger ribonucleic acid levels in the parathyroid glands and kidney of vitamin D-deficient rats are not regulated by plasma calcium or 1,25-dihydroxyvitamin D3.","volume":"136","author":"Rogers","year":"1995","journal-title":"Endocrinology"},{"key":"2020071613521447900_R25","first-page":"2800","article-title":"Genetic influences on bone density: physiological correlates of vitamin D receptor gene alleles in premenopausal women.","volume":"80","author":"Howard","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613521447900_R26"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/82\/6\/1772\/10401904\/jcem1772.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/82\/6\/1772\/10401904\/jcem1772.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:43:09Z","timestamp":1647906189000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/82\/6\/1772\/2656478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6,1]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.82.6.4012","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6,1]]}}}