{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:39:58Z","timestamp":1765960798732},"reference-count":41,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have investigated the effects of iodine (I) intake on urinary I excretion in preterm (PT) babies up to 2 months after birth and its effect on serum T4, free T4 (FT4), T3, TSH, and thyroglobulin (Tg) levels compared to those in term (T) newborns.<\/jats:p><jats:p>Very premature and very sick infants were in negative I balance for the first weeks after birth. Later, these same infants, as well as the other PT and T newborns, were in positive balance; 75\u201380% of the ingested I was not accounted for in the urine. The urinary I levels of PT and T neonates cannot be equated to their I intakes.<\/jats:p><jats:p>T4, FT4, and T3 levels in PT and T neonates increased with postmenstrual age, whereas Tg decreased and TSH did not change. Serum FT4, T3, Tg, and TSH levels in PT neonates were affected negatively, independently from age, by a low I intake. PT birth also affected T4, FT4, and Tg negatively, independently from I intake and postmenstrual age, for at least 6\u20138 weeks after birth.<\/jats:p><jats:p>Care should be taken to avoid I deficiency in PT neonates. However, even when I intake is adequate, PT newborns are hypothyroxinemic compared to T babies during an important period of brain development. This suggests the possible convenience of interventions that might mimic the intrauterine hormone environment and accelerate maturation.<\/jats:p>","DOI":"10.1210\/jcem.82.6.4019","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:01:43Z","timestamp":1389200503000},"page":"1704-1712","source":"Crossref","is-referenced-by-count":5,"title":["Neonatal Hypothyroxinemia: Effects of Iodine Intake and Premature Birth1"],"prefix":"10.1210","volume":"82","author":[{"given":"Susana","family":"Ares","sequence":"first","affiliation":[{"name":"Unidad de Neonatologi\u0301a, Hospital La Paz, Instituto Nacional de Salud (S.A., J.Q.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He\u0301ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinologi\u0301a Molecular, Instituto de Investigaciones Biome\u0301dicas y Facultad de Medicina, Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma (H.F.E.-M., S.D., M.J.P., G.M.d.E.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u0301","family":"Quero","sequence":"additional","affiliation":[{"name":"Unidad de Neonatologi\u0301a, Hospital La Paz, Instituto Nacional de Salud (S.A., J.Q.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Socorro","family":"Dura\u0301n","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinologi\u0301a Molecular, Instituto de Investigaciones Biome\u0301dicas y Facultad de Medicina, Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma (H.F.E.-M., S.D., M.J.P., G.M.d.E.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a Jesus","family":"Presas","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinologi\u0301a Molecular, Instituto de Investigaciones Biome\u0301dicas y Facultad de Medicina, Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma (H.F.E.-M., S.D., M.J.P., G.M.d.E.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Herruzo","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Preventiva, Facultad de Medicina de la Universidad Auto\u0301noma (R.H.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Morreale de Escobar","sequence":"additional","affiliation":[{"name":"Unidad de Endocrinologi\u0301a Molecular, Instituto de Investigaciones Biome\u0301dicas y Facultad de Medicina, Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma (H.F.E.-M., S.D., M.J.P., G.M.d.E.), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071613554004900_R1","first-page":"1719","article-title":"Detection of thyroid hormone in human embryonic cavities 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