{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:13:54Z","timestamp":1773422034681,"version":"3.50.1"},"reference-count":28,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"DOI":"10.1210\/jcem.82.8.4172","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:02:30Z","timestamp":1389182550000},"page":"2601-2606","source":"Crossref","is-referenced-by-count":50,"title":["Chronic Imipramine Is Associated with Diminished Hypothalamic-Pituitary-Adrenal Axis Responsivity in Healthy Humans"],"prefix":"10.1210","volume":"82","author":[{"given":"David","family":"Michelson","sequence":"first","affiliation":[{"name":"Clinical Neuroendocrinology Branch (D.E., E.G., L.H., M.D., P.G.), National Institute of Mental Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Galliven","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology Branch (D.E., E.G., L.H., M.D., P.G.), National Institute of Mental Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Hill","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology Branch (D.E., E.G., L.H., M.D., P.G.), National Institute of Mental Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Demitrack","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology Branch (D.E., E.G., L.H., M.D., P.G.), National Institute of Mental Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Chrousos","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Branch (G.C.), National Institute of Child Health and Development"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Gold","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology Branch (D.E., E.G., L.H., M.D., P.G.), National Institute of Mental Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041117344113400_R1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJM198808113190606","article-title":"Clinical and biochemical manifestations of depression: relation to the neurobiology of stress (Part 1 of 2).","volume":"319","author":"Gold","year":"1988","journal-title":"N Engl J Med"},{"key":"2019041117344113400_R2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1056\/NEJM198808183190706","article-title":"Clinical and biochemical manifestations of depression: relation to the neurobiology of stress (Part 2 of 2).).","volume":"319","author":"Gold","year":"1988","journal-title":"N Engl J Med"},{"key":"2019041117344113400_R3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/297331a0","article-title":"Corticotropin releasing factor produces behavioral activation in the rat.","volume":"297","author":"Sutton","year":"1982","journal-title":"Nature"},{"key":"2019041117344113400_R4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/305232a0","article-title":"Corticotropin releasing factor is potent inhibitor of sexual receptivity in the female rat.","volume":"305","author":"Sirinathsinghji","year":"1983","journal-title":"Nature"},{"key":"2019041117344113400_R5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1210\/endo-114-3-914","article-title":"Influence of corticotropin releasing factor on reproductive functions in the rat.","volume":"114","author":"Rivier","year":"1984","journal-title":"Endocrinology"},{"key":"2019041117344113400_R6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0006-8993(88)90064-9","article-title":"Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in rats.","volume":"457","author":"Kalin","year":"1988","journal-title":"Brain Res"},{"key":"2019041117344113400_R7","author":"Kalin","year":"1991"},{"key":"2019041117344113400_R8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1172\/JCI115086","article-title":"Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase and mineralicorticoid receptor gene expression in rat brain: therapeutic implications.","volume":"87","author":"Brady","year":"1991","journal-title":"J Clin Invest"},{"key":"2019041117344113400_R9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(92)90459-M","article-title":"The antidepressants fluoxetine, idosoxan, and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications.","volume":"572","author":"Brady","year":"1992","journal-title":"Brain Res"},{"key":"2019041117344113400_R10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02245280","article-title":"Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats.","volume":"108","author":"Melia","year":"1992","journal-title":"Psychopharmacology"},{"key":"2019041117344113400_R11","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1176\/ajp.150.11.1618","article-title":"The DST as predictor of outcome in depression: a meta-analysis.","volume":"150","author":"Ribeiro","year":"1993","journal-title":"Am J Psychiatry"},{"key":"2019041117344113400_R12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/archpsyc.1995.03950150045009","article-title":"Adrenal gland volume in major depression. Increase during depressive episode and resolution with successful treatment.","volume":"52","author":"Rubin","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"2019041117344113400_R13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJM198605223142101","article-title":"Responses to corticotropin releasing hormone in the hypercortisolism of depression and Cushing\u2019s disease: pathophysiologic and diagnostic implications.","volume":"314","author":"Gold","year":"1986","journal-title":"N Engl J Med"},{"key":"2019041117344113400_R14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0165-0327(88)90037-7","article-title":"The oCRH test before and after clinical recovery from depression.","volume":"14","author":"Amsterdam","year":"1988","journal-title":"J Affect Disord"},{"key":"2019041117344113400_R15","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/jcem-73-6-1224","volume":"73","author":"Demitrack","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117344113400_R16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1176\/ajp.153.1.93","article-title":"Pituitary-adrenal system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects.","volume":"153","author":"Heuser","year":"1996","journal-title":"Am J Psychiatry"},{"key":"2019041117344113400_R17","first-page":"2","article-title":"Imipramine effect on the hypothalamic-pituitary-adrenal axis response to hypoglycemia.","volume":"41","author":"Kathol","year":"1991","journal-title":"Psychiatry Res"},{"key":"2019041117344113400_R18","first-page":"1127","article-title":"Blunted corticotropin and normal cortisol responses to human corticotropin-releasing factor in depression.","volume":"31","author":"Holsboer","year":"1984","journal-title":"N Engl J Med"},{"key":"2019041117344113400_R19","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1210\/jcem-58-6-1064","article-title":"The corticotropin-releasing hormone stimulation test: a possible aid in the diagnosis of patients with adrenal insufficiency.","volume":"58","author":"Schulte","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117344113400_R20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1210\/jcem-61-1-22","article-title":"Pituitary-adrenal responsiveness to corticotropin-releasing hormone in patients receiving chronic, alternate day gluococorticoid therapy.","volume":"61","author":"Schurmeyer","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117344113400_R21","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/jcem-65-5-906","article-title":"The CRH test in the post-operative evaluation of patients with Cushing\u2019s syndrome.","volume":"65","author":"Avgerinos","year":"1987","journal-title":"J Clin Endcrinol Metab"},{"key":"2019041117344113400_R22","first-page":"185","article-title":"Corticotropin-releasing factor in humans. II. CRH stimulation in patients with diseases of the hypothalamic-pituitary-adrenal axis.","volume":"25","author":"Muller","year":"1987","journal-title":"Hom Res"},{"key":"2019041117344113400_R23","first-page":"173","article-title":"The pituitary corticotroph is not the rate-limiting step in the post-operative recovery of the hypothalamic-pituitary-adrenal axis in patients with Cushing\u2019s syndrome.","volume":"77","author":"Gomez","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117344113400_R24","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1210\/jcem-72-6-1382","article-title":"Abnormal pituitary-adrenal responses to corticotropin-releasing hormone in patients with seasonal affective disorder: clinical and pathophysiological implications.","volume":"72","author":"Joseph-Vanderpool","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117344113400_R25","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1172\/JCI113382","article-title":"Vasopressin stimulation of adrenocroticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRH mediation of the diurnal rhythm of ACTH.","volume":"81","author":"Salata","year":"1988","journal-title":"J Clin Invest"},{"key":"2019041117344113400_R26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI111240","article-title":"Arginine vasopressin potentiates adrenocorticotropin release induced by corticotropin-releasing factor.","volume":"73","author":"DeBold","year":"1984","journal-title":"J Clin Invest"},{"key":"2019041117344113400_R27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1523\/JNEUROSCI.07-06-01732.1987","article-title":"Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation.","volume":"7","author":"Simson","year":"1987","journal-title":"J neurosci"},{"key":"2019041117344113400_R28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1172\/JCI113687","article-title":"Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.","volume":"82","author":"Calaogero","year":"1988","journal-title":"J Clin Invest"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/82\/8\/2601\/9277736\/jcem2601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:55:50Z","timestamp":1555034150000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/82\/8\/2601\/2877655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.82.8.4172","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}