{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:31:49Z","timestamp":1721637109202},"reference-count":48,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>Administration of insulin-like growth factor-I (IGF-I) or growth hormone (GH) is known to stimulate bone turnover and kidney function. To investigate the effects of IGF-I and GH on markers of bone turnover, eight adult GH-deficient patients (48 \u00b1 14 yr of age) were treated with IGF-I (5 \u03bcg\/kg\/h in a continuous sc infusion) and GH (0.03 IU\/kg\/daily sc injection at 2000 h) in a randomized cross-over study. We monitored baseline values for three consecutive days before initiating the five-day treatment period, as well as the wash-out period of ten weeks. Serum osteocalcin, carboxyterminal and aminoterminal propeptide of type I procollagen (PICP and PINP, respectively) increased significantly within 2\u20133 days of both treatments (P &amp;lt; 0.02) and returned to baseline levels within one week after the treatment end. The changes in resorption markers were less marked as compared with formation markers. Total 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) rose significantly, whereas PTH and calcium levels remained unchanged during either treatment. Conclusions: Because the rapid increase in markers of bone formation was not preceded by an increase in resorption markers, IGF-I is likely to stimulate bone formation by a direct effect on osteoblasts. Moreover, because PTH, calcium, and phosphate remained unchanged, IGF-I appears to stimulate renal 1\u03b1-hydroxylase activity in vivo.<\/jats:p>","DOI":"10.1210\/jcem.83.1.4484","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:02:30Z","timestamp":1389200550000},"page":"81-87","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Short-Term Insulin-Like Growth Factor-I (IGF-I) or Growth Hormone (GH) Treatment on Bone Metabolism and on Production of 1,25-Dihydroxycholecalciferol in GH-Deficient Adults1"],"prefix":"10.1210","volume":"83","author":[{"given":"Tarcisio","family":"Bianda","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism (T.B., Y.G., E.R.F., C.S.), Department of Internal Medicine, University Hospital, CH-8091 Zu\u0308rich, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Glatz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (T.B., Y.G., E.R.F., C.S.), Department of Internal Medicine, University Hospital, CH-8091 Zu\u0308rich, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Bouillon","sequence":"additional","affiliation":[{"name":"Laboratorium voor Experimentele Geneeskunde en Endocrinologie (R.B.), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst Rudolf","family":"Froesch","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (T.B., Y.G., E.R.F., C.S.), Department of Internal Medicine, University Hospital, CH-8091 Zu\u0308rich, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (T.B., Y.G., E.R.F., C.S.), Department of Internal Medicine, University Hospital, CH-8091 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