{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T20:44:29Z","timestamp":1706647469834},"reference-count":8,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>Endocrine systems may be affected permanently by administration of supraphysiologic doses of hormone. This is a well known complication of glucocorticoid treatment where the pituitary\/adrenal axis may never fully recover, especially when large doses of steroids are needed during significant physical stress. The goal of this investigation was to determine whether responsivity of the parathyroid gland was normal after use of (1\u201334)PTH daily as an investigational therapy for osteoporosis. Patients were all postmenopausal osteoporotic women treated with estrogen and enrolled in a 3-yr trial of (1\u201334)PTH by daily subcutaneous injection (400 IU\/day) in addition to their estrogen therapy. A volunteer subgroup (n = 10) of this population was recruited for this investigation. All patients had an EDTA-provoked hypocalcemic challenge before beginning PTH treatment. The same patients had repeat EDTA-challenge tests at various times during the 3-yr PTH treatment trial. Three patients had 2 infusions while on PTH treatment (interim and at the end of 3 yr). Ionized calcium declined identically before and during PTH treatment in response to the EDTA stimulus. PTH(1\u201384) responses were identical before and during PTH therapy. Furthermore, there were no differences in 1,25(OH)2D elevation or in phosphorus reduction over the course of the EDTA infusion during daily PTH treatment. Osteocalcin levels were higher during PTH treatment, as expected, but responsivity to acute endogenous PTH elevations was the same after PTH treatment. We conclude that 1\u201334PTH therapy, at 400 IU\/day for up to 3 yr, does not suppress parathyroid responsivity and should therefore (at least within this period of treatment) have no permanent adverse effect on the ability of the body to maintain calcium homeostasis. Additionally, there is no difference in target organ responsivity to acute endogenous elevations of PTH after exogenous PTH therapy.<\/jats:p>","DOI":"10.1210\/jcem.83.3.4639","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:02:57Z","timestamp":1389200577000},"page":"788-790","source":"Crossref","is-referenced-by-count":1,"title":["Parathyroid Responsivity in Postmenopausal Women with Osteoporosis During Treatment with Parathyroid Hormone1"],"prefix":"10.1210","volume":"83","author":[{"given":"Felicia","family":"Cosman","sequence":"first","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"},{"name":"Department of Medicine (F.C., R.L.), New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeri","family":"Nieves","sequence":"additional","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"},{"name":"Department of Epidemiology (J.N.), New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Woelfert","sequence":"additional","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Gordon","sequence":"additional","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"},{"name":"Department of Pathology (V.S.), Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Clinical Research and Regional Bone Centers (F.C., J.N., L.W., S.G., V.S., R.L.), Helen Hayes Hospital, West Haverstraw, New York 10993"},{"name":"Department of Medicine (F.C., R.L.), New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071618245865700_R1","first-page":"690","article-title":"Anabolic actions of parathyroid hormone on bone.","volume":"14","author":"Dempster","year":"1993","journal-title":"Endocr Rev"},{"key":"2020071618245865700_R2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)02342-8","article-title":"Parathyroid hormone increases vertebral bone mass and may reduce vertebral fracture incidence in estrogen treated postmenopausal women with osteoporosis.","volume":"350","author":"Lindsay","year":"1997","journal-title":"Lancet"},{"key":"2020071618245865700_R3"},{"key":"2020071618245865700_R4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1210\/jcem-25-1-11","article-title":"Natural history of pituitary-adrenal recovery following long-term suppression with corticosteroids.","volume":"25","author":"Graber","year":"1965","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071618245865700_R5","first-page":"939","article-title":"Effects of estrogen on response to EDTA infusion in postmenopausal osteoporotic women.","volume":"78","author":"Cosman","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071618245865700_R6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1359\/jbmr.1997.12.6.958","article-title":"Resistance to bone resorbing effects of PTH in black women.","volume":"12","author":"Cosman","year":"1997","journal-title":"J Bone Miner Res"},{"key":"2020071618245865700_R7","first-page":"1535","article-title":"Subcutaneous administration of the amino terminal fragment of human parathyroid hormone (1\u201334hPTH): kinetics and biochemical response in estrogenized osteoporotic patients.","volume":"77","author":"Lindsay","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071618245865700_R8","author":"Doherty","year":"1995"}],"container-title":["The Journal of Clinical Endocrinology &amp; 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