{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:36:02Z","timestamp":1768250162259,"version":"3.49.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,6,1]]},"DOI":"10.1210\/jcem.83.6.4879","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:03:27Z","timestamp":1389200607000},"page":"2192-2198","source":"Crossref","is-referenced-by-count":7,"title":["Up-Regulation by Progesterone of Proliferating Cell Nuclear Antigen and Epidermal Growth Factor Expression in Human Uterine Leiomyoma1"],"prefix":"10.1210","volume":"83","author":[{"given":"Yosuke","family":"Shimomura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takasi","family":"Samoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takesi","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041118061738700_R1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1471-0528.1990.tb01804.x","article-title":"Uterine fibroids.","volume":"97","author":"Vollenhoven","year":"1990","journal-title":"Br J Obstet Gynecol"},{"key":"2019041118061738700_R2","first-page":"4092","article-title":"Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability.","volume":"50","author":"Fletcher","year":"1990","journal-title":"Cancer Res"},{"key":"2019041118061738700_R3","first-page":"209","article-title":"Uterine leiomyomas: cytogenetic and histologic profile.","volume":"80","author":"Meloni","year":"1992","journal-title":"Obstet Gynecol"},{"key":"2019041118061738700_R4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-4608(91)90229-N","article-title":"Chromosome analysis of 96 uterine leiomyomas.","volume":"55","author":"Pandis","year":"1991","journal-title":"Cancer Genet Cytogenet"},{"key":"2019041118061738700_R5","author":"Rein","year":"1992"},{"key":"2019041118061738700_R6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0002-9378(80)90005-8","article-title":"Myomas of the uterus in pregnancy: ultrasonographic follow-up.","volume":"138","author":"Muran","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"2019041118061738700_R7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7863\/jum.1992.11.10.511","article-title":"Longitudinal evaluation of uterine myoma growth during pregnancy. A sonographic study.","volume":"11","author":"Rosati","year":"1992","journal-title":"J Ultrasound Med"},{"key":"2019041118061738700_R8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0015-0282(16)59288-7","article-title":"Shrinkage of uterine fibroids during therapy with goserelin (Zoladex): a lutenizing hormone-releasing hormone agonist administered as a monthly subcutaneous depot.","volume":"48","author":"West","year":"1987","journal-title":"Fertil Steril"},{"key":"2019041118061738700_R9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1210\/mend-4-3-510","article-title":"Estrogen regulates synthesis of epidermal growth factor in mouse uterine epithelial cells.","volume":"4","author":"Huet-Hudson","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2019041118061738700_R10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/edrv-11-3-443","article-title":"Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation.","volume":"11","author":"Murphy","year":"1990","journal-title":"Endocr Rev"},{"key":"2019041118061738700_R11","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1210\/endo.131.4.1396310","article-title":"Transforming growth factor a is a potential mediator of estrogen action in the mouse uterus.","volume":"131","author":"Nelson","year":"1992","journal-title":"Endocrinology"},{"key":"2019041118061738700_R12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis.","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int Rev Cytol"},{"key":"2019041118061738700_R13","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.8430327","article-title":"Cell death studies yield cancer clues.","volume":"259","year":"1993","journal-title":"Science"},{"key":"2019041118061738700_R14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1182\/blood.V80.4.879.879","article-title":"BCL-2 initiates a new category of oncogenes: regulators of cell death.","volume":"80","year":"1992","journal-title":"Blood"},{"key":"2019041118061738700_R15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.124.1.1","article-title":"Bcl-2 and the regulation of programmed cell death.","volume":"124","year":"1994","journal-title":"J Cell Biol"},{"key":"2019041118061738700_R16","first-page":"293","article-title":"Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone.","volume":"82","author":"Matsuo","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118061738700_R17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0014-4827(86)90520-3","article-title":"Expression of proliferating cell nuclear antigen (PCNA)\/cyclin during the cell cycle.","volume":"166","author":"Kurki","year":"1986","journal-title":"Exp Cell Res"},{"key":"2019041118061738700_R18","first-page":"841","article-title":"Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies.","volume":"111","author":"Robbins","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"2019041118061738700_R19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1210\/jcem-58-5-880","article-title":"Binding sites for epidermal growth factor in human uterine tissues and leiomyoma.","volume":"58","author":"Hofmann","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118061738700_R20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1073\/pnas.88.1.21","article-title":"Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation.","volume":"88","author":"Nelson","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041118061738700_R21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0015-0282(16)54681-0","article-title":"Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyoma.","volume":"56","author":"Yeh","year":"1991","journal-title":"Fertil Steril"},{"key":"2019041118061738700_R22","first-page":"1716","article-title":"Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro.","volume":"130","author":"Rossi","year":"1992","journal-title":"Endocrinology"},{"key":"2019041118061738700_R23","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1073\/pnas.83.8.2496","article-title":"Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen responsive cells in culture.","volume":"83","author":"Berthois","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041118061738700_R24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0303-7207(88)90072-X","article-title":"Estrogenic activity of phenol red.","volume":"57","author":"Welshons","year":"1988","journal-title":"Mol Cell Endocrinol"},{"key":"2019041118061738700_R25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","article-title":"Dating the endometrial biopsy.","volume":"1","author":"Noyes","year":"1950","journal-title":"Fertil Steril"},{"key":"2019041118061738700_R26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0002-9378(87)90086-X","article-title":"Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in human placenta: implication for trophoblast proliferation and differentiation.","volume":"156","author":"Maruo","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"2019041118061738700_R27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the princple of protein-dye binding.","volume":"72","year":"1976","journal-title":"Anal Biochem"},{"key":"2019041118061738700_R28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/107155769400100212","article-title":"Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage.","volume":"1","author":"Sakuragi","year":"1994","journal-title":"J Soc Gynecol Invest"},{"key":"2019041118061738700_R29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0002-9378(93)90135-6","article-title":"Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas.","volume":"169","author":"Brandon","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"2019041118061738700_R30","first-page":"1876","article-title":"Estrogen receptor gene expression in human uterine leiomyomata.","volume":"80","author":"Brandon","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118061738700_R31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/edrv-11-3-443","article-title":"Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation.","volume":"11","author":"Murphy","year":"1990","journal-title":"Endocr Rev"},{"key":"2019041118061738700_R32","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/nar\/20.10.2441","article-title":"Purification of PCNA as a nucleotide excision repair protein.","volume":"20","author":"Nichols","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041118061738700_R33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0092-8674(92)90416-A","article-title":"Proliferating cell nuclear antigen is required for DNA excision repair.","volume":"69","author":"Shivji","year":"1992","journal-title":"Cell"},{"key":"2019041118061738700_R34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02109824","article-title":"Sex steroid levels in serum, myometrium, and fibromyomata in correlation with cytoplasmic receptors and 17-beta-hy-droxysteroid dehydrogenase acyivity in different age groups and phase of the menstrual cycle.","volume":"229","author":"Eiletz","year":"1980","journal-title":"Arch Gyneccol"},{"key":"2019041118061738700_R35","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1471-0528.1988.tb06821.x","article-title":"The binding of epidermal growth factor to the human uterus and leiomyomata in women rendered hypo-oestrogenic by continuous administration of an LHRH agonist.","volume":"95","author":"Lumsden","year":"1988","journal-title":"Br J Obstet Gynecol"},{"key":"2019041118061738700_R36","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/303722a0","article-title":"Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor.","volume":"303","author":"Gray","year":"1983","journal-title":"Nature"},{"key":"2019041118061738700_R37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.6602382","article-title":"Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins.","volume":"221","author":"Scott","year":"1983","journal-title":"Science"},{"key":"2019041118061738700_R38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1432-0436.1990.tb00454.x","article-title":"Expression of epidermal growth factor in the kidney and submandibular gland during mouse postnatal development. An immunocytochemical and in situ hybridization study.","volume":"45","author":"Salido","year":"1990","journal-title":"Differentiation"},{"key":"2019041118061738700_R39","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9378(89)80046-8","article-title":"Mitotic activity in uterine leiomyomas during the menstrual cycle.","volume":"160","author":"Kawaguchi","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"2019041118061738700_R40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004347-198506000-00001","article-title":"The effect of progestins on the mitotic activity of uterine fibromyomas.","volume":"4","year":"1985","journal-title":"Int J Gynecol Pathol"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/83\/6\/2192\/9234813\/jcem2192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T15:44:10Z","timestamp":1597333450000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/83\/6\/2192\/2865707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.83.6.4879","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6,1]]}}}