{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:56:50Z","timestamp":1718135810104},"reference-count":27,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>The majority of patients with Cushing\u2019s disease can be cured by transsphenoidal microsurgery; however, precise localization of the pituitary source of ACTH is not always possible by standard imaging techniques. Bilateral venous sampling from the inferior petrosal sinuses (IPSS) is also useful for diagnosing Cushing\u2019s disease, but the interpretation of discordant findings between IPSS and imaging remains problematic. We tested the ability of imaging and IPSS to localize an ACTH-secreting pituitary lesion in comparison to definitive histopathological examination of the pituitary in patients with Cushing\u2019s disease (n = 37). Bilateral IPS catheterization was technically feasible in 32 patients and provided evidence of lateralization in 31 patients. Histological examination confirmed a corticotropic adenoma in 28 patients and corticotropic hyperplasia in 2 patients; Crooke\u2019s hyaline change was found in 7 patients, among whom 1 subsequently was found to have an ectopic sphenoid corticotropic adenoma, and the remainder had suspected microadenomas that were not identified microscopically. Accurate localization of the pituitary lesion was more frequent when based on IPSS results than on imaging studies (70% vs. 49%, P &amp;lt; 0.06). The 2 tests provided directly discrepant results for 8 patients; among these, IPSS was more likely than imaging to agree with final pathology (63% vs. 13%, P &amp;lt; 0.10). Imaging was entirely normal for another 9 patients, in whom IPSS accurately localized the lesion for the majority (89%; 95% confidence interval: 50\u201399%). We suggest that IPSS is an effective tool for localizing pituitary pathology and planning surgery for patients with Cushing\u2019s disease.<\/jats:p>","DOI":"10.1210\/jcem.83.7.4956","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:03:28Z","timestamp":1389200608000},"page":"2291-2295","source":"Crossref","is-referenced-by-count":7,"title":["Improved Diagnostic Accuracy of Inferior Petrosal Sinus Sampling over Imaging for Localizing Pituitary Pathology in Patients with Cushing\u2019s Disease"],"prefix":"10.1210","volume":"83","author":[{"given":"Gillian L.","family":"Booth","sequence":"first","affiliation":[{"name":"Departments of Medicine (G.L.B., D.A.R., S.E.), Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Redelmeier","sequence":"additional","affiliation":[{"name":"Departments of Medicine (G.L.B., D.A.R., S.E.), Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Grosman","sequence":"additional","affiliation":[{"name":"Radiology (H.G.), Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Pathology (K.K.), Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harley S.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Neurosurgery (H.S.S.), University of Toronto, Toronto, Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Departments of Medicine (G.L.B., D.A.R., S.E.), Ontario, Canada M5G-1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071619332201500_R1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.7326\/0003-4819-109-6-487","article-title":"Transsphenoidal microsurgery for Cushing disease. A report of 216 cases.","volume":"109","author":"Mampalam","year":"1988","journal-title":"Ann Intern Med"},{"key":"2020071619332201500_R2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0889-8529(18)30081-1","article-title":"Biochemical and radiologic diagnosis of Cushing\u2019s syndrome.","volume":"23","author":"Findling","year":"1994","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2020071619332201500_R3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7326\/0003-4819-76-3-112-6-434","article-title":"The Cushing syndrome: an update on diagnostic tests.","volume":"112","author":"Kaye","year":"1990","journal-title":"Ann Intern Med"},{"key":"2020071619332201500_R4","first-page":"1183","article-title":"The accuracy of CT and MR evaluation of the sella turcica for detection of adrenocorticotropic hormone-secreting adenomas in Cushing disease.","volume":"14","author":"Buchfelder","year":"1993","journal-title":"Am J Neuroradiol"},{"key":"2020071619332201500_R5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1148\/radiology.162.3.3809493","article-title":"Cushing syndrome: pituitary CT scanning.","volume":"162","author":"Saris","year":"1987","journal-title":"Radiology"},{"key":"2020071619332201500_R6","first-page":"949","article-title":"Gd-DTPA-enhanced MR imaging of pituitary adenomas.","volume":"10","author":"Newton","year":"1989","journal-title":"Am J Neuroradiol"},{"key":"2020071619332201500_R7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2214\/ajr.152.1.145","article-title":"High-resolution MR imaging of pituitary microadenomas at 1.5 T: experience with Cushing disease.","volume":"152","author":"Peck","year":"1989","journal-title":"AJR Am J Roentgenol"},{"key":"2020071619332201500_R8","first-page":"1591","article-title":"MR of corticotropin-secreting pituitary microadenomas.","volume":"15","author":"Colombo","year":"1994","journal-title":"Am J Neuroradiol"},{"key":"2020071619332201500_R9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-120-10-199405150-00001","article-title":"Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population.","volume":"120","author":"Hall","year":"1994","journal-title":"Ann Intern Med"},{"key":"2020071619332201500_R10","first-page":"1075","article-title":"Anatomy of the junction of the inferior petrosal sinus and the internal jugular vein.","volume":"14","author":"Miller","year":"1993","journal-title":"Am J Neuroradiol"},{"key":"2020071619332201500_R11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1148\/radiology.150.1.6316418","article-title":"Petrosal sinus sampling for Cushing syndrome: anatomical and technical considerations.","volume":"150","author":"Doppman","year":"1984","journal-title":"Radiology"},{"key":"2020071619332201500_R12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJM199109263251301","article-title":"Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing\u2019s syndrome.","volume":"325","author":"Oldfield","year":"1991","journal-title":"N Engl J Med"},{"key":"2020071619332201500_R13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2265.1996.d01-1550.x","article-title":"Petrosal sinus sampling for diagnosis of Cushing\u2019s disease: evidence of false negative results.","volume":"45","author":"Lo\u0301pez","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619332201500_R14","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3171\/jns.1995.83.6.1087","article-title":"False-positive inferior petrosal sinus sampling in the diagnosis of Cushing\u2019s disease. Report of two cases.","volume":"83","author":"Yamamoto","year":"1995","journal-title":"J Neurosurg"},{"key":"2020071619332201500_R15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2265.1994.tb02448.x","article-title":"Pituitary tumour localization in patients with Cushing\u2019s disease by magnetic resonance imaging. Is there a place for petrosal sinus sampling?","volume":"40","author":"Herder","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619332201500_R16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1148\/radiology.176.2.2164235","article-title":"Petrosal sinus sampling: discordant lateralization of ACTH-secreting pituitary microadenomas before and after stimulation with corticotropin-releasing hormone.","volume":"176","author":"Miller","year":"1990","journal-title":"Radiology"},{"key":"2020071619332201500_R17","first-page":"503","article-title":"The limited ability of inferior petrosal sinus sampling with corticotropin-releasing hormone to distinguish Cushing\u2019s disease from pseudo-Cushing states or normal physiology.","volume":"77","author":"Yanovski","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619332201500_R18","first-page":"176","article-title":"A combined test using desmopressin and corticotropin-releasing hormone in the differential diagnosis of Cushing\u2019s syndrome.","volume":"82","author":"Newell-Price","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619332201500_R19","author":"Fleiss","year":"1981"},{"key":"2020071619332201500_R20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2265.1994.tb02487.x","article-title":"The value of inferior petrosal sinus sampling in diagnosis and treatment of Cushing\u2019s disease.","volume":"40","author":"Landolt","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619332201500_R21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jcem-73-1-53","article-title":"Usefulness of the corticotropin-releasing hormone test during bilateral inferior petrosal sinus sampling for the diagnosis of Cushing\u2019s disease.","volume":"73","author":"Tabarin","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619332201500_R22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2265.1989.tb03737.x","article-title":"Bilateral inferior petrosal sinus sampling as a routine procedure in ACTH-dependent Cushing\u2019s syndrome.","volume":"30","author":"McCance","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619332201500_R23","author":"ASA","year":"1998"},{"key":"2020071619332201500_R24","first-page":"475","article-title":"Venous angiography is needed to interpret inferior petrosal sinus and cavernous sinus sampling data for lateralizing adrenocorticotropin-secreting adenomas.","volume":"81","author":"Mamelak","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619332201500_R25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02739709","article-title":"Cushing\u2019s syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical and ultrastructural study and review of the literature.","volume":"8","author":"Coire","year":"1997","journal-title":"Endocr Pathol"},{"key":"2020071619332201500_R26","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1172\/JCI118640","article-title":"Inferior petrosal sinus sampling in healthy human subjects reveals a unilateral corticotropin-releasing hormone-induced arginine vasopressin release associated with ipsilateral adrenocorticotropin secretion.","volume":"97","author":"Kalogeras","year":"1996","journal-title":"J Clin Invest"},{"key":"2020071619332201500_R27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1148\/radiology.185.1.1523298","article-title":"Neurologic complications of petrosal sinus sampling.","volume":"185","author":"Miller","year":"1992","journal-title":"Radiology"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/83\/7\/2291\/13121885\/jcem2291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/83\/7\/2291\/13121885\/jcem2291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T04:37:27Z","timestamp":1594960647000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/83\/7\/2291\/2865232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7,1]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.83.7.4956","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7,1]]}}}