{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:25:58Z","timestamp":1792135558726,"version":"4.4.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"DOI":"10.1210\/jcem.83.7.4958","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:03:28Z","timestamp":1389200608000},"page":"2302-2308","source":"Crossref","is-referenced-by-count":1,"title":["Thyrotropin Receptor Epitopes Recognized by Graves\u2019 Autoantibodies Developing under Immunosuppressive Therapy"],"prefix":"10.1210","volume":"83","author":[{"given":"Jacobo","family":"Wortsman","sequence":"first","affiliation":[{"name":"Departments of Medicine (J.W.), Springfield, Illinois 62701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McConnachie","sequence":"additional","affiliation":[{"name":"Microbiology Immunology (P.M.), Southern Illinois University School of Medicine, Springfield, Illinois 62701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tahara","sequence":"additional","affiliation":[{"name":"the Second Department of Internal Medicine, Chiba University School of Medicine (K.T.), Chiba 260, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard D.","family":"Kohn","sequence":"additional","affiliation":[{"name":"the Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (L.D.K.), Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041117210189000_R1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1210\/edrv-6-2-183","article-title":"Immune mechanisms in Graves\u2019 disease.","volume":"6","author":"Burman","year":"1985","journal-title":"Endocr Rev"},{"key":"2019041117210189000_R2","first-page":"788","article-title":"Autoimmune thyroid disease: further developments in our understanding.","volume":"15","author":"Weetman","year":"1994","journal-title":"Endocr Rev"},{"key":"2019041117210189000_R3","author":"Kohn","year":"1995"},{"key":"2019041117210189000_R4","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1073\/pnas.93.20.11074","article-title":"Induction of Graves\u2019-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule.","volume":"93","author":"Shimojo","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041117210189000_R5","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1210\/jcem.82.12.4589","article-title":"Genetic control of anti-thyrotropin receptor antibody generation in H-2k mice immunized with thyrotropin receptor-transfected fibroblasts.","volume":"82","author":"Yamaguchi","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R6","first-page":"1758","article-title":"Epitopes for thyroid stimulating antibodies in Graves\u2019 sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment.","volume":"81","author":"Kim","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R7","first-page":"1953","article-title":"Changes in epitopes for thyroid stimulating antibodies in Graves\u2019 sera during treatment of hyperthyroidism: therapeutic implications.","volume":"82","author":"Kim","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R8"},{"key":"2019041117210189000_R9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/00039896.1992.9938365","article-title":"Immune alterations in humans exposed to the termiticide; technical chlordane.","volume":"47","author":"McConnachie","year":"1992","journal-title":"Arch Environ Health"},{"key":"2019041117210189000_R10","first-page":"3998","article-title":"Characterization of monoclonal thyroid stimulating and thyrotropin binding inhibiting autoantibodies from a Hashimoto\u2019s patient whose children had intrauterine and neonatal thyroid disease.","volume":"82","author":"Kohn","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R11","first-page":"609","article-title":"Clinical determination and\/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line FRTL-5. U.S.","volume":"4","author":"Kohn","year":"1986","journal-title":"patent no"},{"key":"2019041117210189000_R12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0006-291X(91)91335-A","article-title":"Immunoglobulins from Graves\u2019 disease patients interact with different sites on TSH receptor\/LH-CG receptor chimeras than either TSH or Immunoglobulins from idiopathic myxedema patients.","volume":"179","author":"Tahara","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041117210189000_R13","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/thy.1997.7.867","article-title":"Epitopes for thyroid stimulating and blocking autoantibodies on the extracellular domain of the human thyrotropin receptor.","volume":"7","author":"Tahara","year":"1997","journal-title":"Thyroid"},{"key":"2019041117210189000_R14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/thy.1997.7.13","article-title":"Subtypes of anti-TSH receptor antibodies classified by bio- and conversion assays using CHO cells expressing wild type human TSH receptor or TSH receptor-LH\/CG receptor chimera.","volume":"7","author":"Watanabe","year":"1997","journal-title":"Thyroid"},{"key":"2019041117210189000_R15","first-page":"1164","article-title":"Receptor crosstalk can optimize assays for autoantibodies to the thyrotropin receptor: effect of phenylisopropyladenosine on cAMP and inositol phosphate levels in rat FRTL-5 thyroid cells.","volume":"77","author":"Hidaka","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R16","first-page":"2785","article-title":"Subgroups of Graves\u2019 patients identified on the basis of the biochemical activities of their immunoglobulins.","volume":"80","author":"Di Cerbo","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R17","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJM198310273091705","article-title":"Antibodies that promote thyroid growth: a distinct population of thyroid-stimulating autoantibodies.","volume":"309","author":"Valente","year":"1983","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/00039896.1991.9937456","article-title":"Immunologic consequence of exposure to pentachlorophenol.","volume":"46","author":"McConnachie","year":"1991","journal-title":"Arch Env Health"},{"key":"2019041117210189000_R19","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1056\/NEJM199609193351205","article-title":"Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts.","volume":"335","author":"Tyden","year":"1996","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R20","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/archderm.1986.01660230080015","article-title":"Cutaneous malignant neoplasms in patients with renal transplants.","volume":"122","author":"Gupta","year":"1986","journal-title":"Arch Dermatol"},{"key":"2019041117210189000_R21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0140-6736(97)80015-3","article-title":"Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients.","volume":"349","author":"Glover","year":"1997","journal-title":"Lancet"},{"key":"2019041117210189000_R22","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJM199612053352306","article-title":"Chorionic tumors.","volume":"335","author":"Berkowitz","year":"1996","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0002-9343(92)90263-B","article-title":"T-Lymphocyte activation in adult-onset idiopathic hypoparathyroidism.","volume":"92","author":"Wortsman","year":"1992","journal-title":"Am J Med"},{"key":"2019041117210189000_R24","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM198505303122201","article-title":"In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.","volume":"312","author":"Hafler","year":"1985","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJM199107253250404","article-title":"Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease.","volume":"325","author":"Davies","year":"1991","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R26","first-page":"345","article-title":"In utero and postnatal exposure to 2,3,7,8-TCDD in Times Beach, MO. I. Immunological effects: lymphocyte phenotype frequencies.","volume":"13","author":"Smoger","year":"1993","journal-title":"TOX"},{"key":"2019041117210189000_R27","author":"Kohn","year":"1985"},{"key":"2019041117210189000_R28","author":"Rees","year":"1993"},{"key":"2019041117210189000_R29","doi-asserted-by":"crossref","first-page":"11453","DOI":"10.1074\/jbc.270.19.11453","article-title":"Hormonal modulation of MHC class I gene expression involves an enhancer A-binding complex consisting of fra-2 and the p50 subunit of NF-B.","volume":"270","author":"Giuliani","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041117210189000_R30","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJM199006143222404","article-title":"Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing\u2019s syndrome due to an adrenocortical adenoma.","volume":"322","author":"Takasu","year":"1990","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF03346895","article-title":"Graves\u2019 hyperthyroidism and ophthalmopathy associated with pemphigus vulgaris: onset of thyroid autoimmune disease during chronic low-dose glucocorticoid therapy.","volume":"20","author":"Bartalena","year":"1997","journal-title":"J Endocrinol Invest"},{"key":"2019041117210189000_R32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/thy.1996.6.457","article-title":"The transition of subacute thyroiditis to Graves\u2019 disease as evidenced by diagnostic imaging.","volume":"6","author":"Bennedbaek","year":"1996","journal-title":"Thyroid"},{"key":"2019041117210189000_R33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM196402062700604","article-title":"Thyrotoxicosis occurring in two patients on prolonged high doses of steroids.","volume":"270","author":"Brown","year":"1964","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/thy.1995.5.477","article-title":"Endocrine ophthalmopathy in a patient under continuous immunosuppresive therapy after cardiac transplantation.","volume":"5","author":"Hofle,","year":"1995","journal-title":"Thyroid"},{"key":"2019041117210189000_R35","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1056\/NEJM198411223112106","article-title":"Antithyroid drugs.","volume":"311","year":"1984","journal-title":"N Engl J Med"},{"key":"2019041117210189000_R36","first-page":"111","article-title":"Inhibition of the receptor for interleukin-2 induced by carbimazole: relevance for the therapy of autoimmune thyroid disease.","volume":"60","author":"Signore","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"2019041117210189000_R37","first-page":"258","article-title":"Immunomodulation by methimazole therapy in Graves\u2019 disease: rapid changes in activation stage of circulating regulatory T cell subsets, B cells and NK cells.","volume":"74","author":"Karlsson","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"2019041117210189000_R38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0192-0561(96)00045-8","article-title":"Methimazole inhibits peripheral lymphocyte proliferation by inducing S-quiescent phase arrest.","volume":"18","author":"Chabernaud","year":"1996","journal-title":"Int J Immunopharmacol"},{"key":"2019041117210189000_R39","first-page":"871","article-title":"MHC class I expression in rat thyroid cells is regulated by hormones, methimazole, and iodide, as well as interferon.","volume":"75","author":"Saji","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041117210189000_R40","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1210\/endo.139.1.5658","article-title":"Regulation of major histocompatibility (MHC) class II gene expression in thyrocytes: opposite effects of interferon and methimazole.","volume":"139","author":"Montani","year":"1998","journal-title":"Endocrinology"},{"key":"2019041117210189000_R41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4049\/jimmunol.153.2.873","article-title":"Methimazole can prevent development of disease in an experimental model of systemic lupus erythematosus.","volume":"153","author":"Singer","year":"1994","journal-title":"J Immunol"},{"key":"2019041117210189000_R42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.8316860","article-title":"Mice deficient in expression of MHC class I are resistant to experimental systemic lupus erythematosus.","volume":"261","author":"Mozes","year":"1993","journal-title":"Science"},{"key":"2019041117210189000_R43","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.4049\/jimmunol.154.9.4830","article-title":"Periocular inflammation in mice with experimental systemic lupus erythematosus (SLE): a new experimental blepharitis and its modulation.","volume":"154","author":"Chan","year":"1995","journal-title":"J Immunol"},{"key":"2019041117210189000_R44","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-4362.1995.tb01598.x","article-title":"Effect of orally administered antithyroid thioureylenes on PCNA and p53 expression in psoriatic lesions.","volume":"34","author":"Elias","year":"1995","journal-title":"Int J Dermatol"},{"key":"2019041117210189000_R45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2036.1997.127299000.x","article-title":"Anti-thyroid drugs decrease mucosal damage in a rat model of experimental colitis.","volume":"11","author":"Oren","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"2019041117210189000_R46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1023\/A:1023242732212","article-title":"Spontaneous autoimmune disease in (NZBXNZW) F1 mice is ameliorated by treatment with methimazole.","volume":"18","author":"Mozes","year":"1998","journal-title":"J Clin Immunol"},{"key":"2019041117210189000_R47","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1210\/endo.139.4.5876","article-title":"The formation of thyrotropin receptor (TSHR) antibodies in a Graves\u2019 animal model requires the N-terminal segment of the TSHR extracellular domain.","volume":"139","author":"Kikuoka","year":"1998","journal-title":"Endocrinology"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/83\/7\/2302\/13122048\/jcem2302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T14:53:32Z","timestamp":1688914412000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/83\/7\/2302\/2865245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7,1]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.83.7.4958","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7,1]]}}}