{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:53:25Z","timestamp":1790045605299,"version":"4.0.1"},"reference-count":27,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:title>abstract<\/jats:title>\n               <jats:p>Abnormal responsiveness of adrenocortical cells to gastric inhibitory polypeptide (GIP) in food-dependent Cushing\u2019s syndrome suggested that adrenal expression of ectopic, overexpressed, or mutated GIP receptor (GIPR) underlies this syndrome. The expression of GIPR was studied by RT-PCR in human adrenal tissues from two patients with GIP-dependent Cushing\u2019s syndrome (adenoma, bilateral hyperplasia), five fetal or adult controls, one patient with Cushing\u2019s disease, and four patients with non-food-dependent cortisol-secreting adenomas or bilateral hyperplasias and compared to that in normal pancreas. Hybridization of the RT-PCR-amplified ribonucleic acids with the human GIPR complementary DNA showed an overexpression of GIPR in the adrenals of the two GIP-dependent Cushing\u2019s syndrome patients compared to that in normal adrenal tissues (2\u20133 orders of magnitude) or pancreas (10-fold); no signal could be seen in adrenal adenomas or macronodular hyperplasia from cases of non-food-dependent Cushing\u2019s syndrome. No mutation of the GIPR was identified by sequencing the full-length receptor in GIP-dependent adrenal tissue. New alternative spliced isoforms of the GIPR were found, but are identical in GIP-dependent and normal adrenal tissues. Incubation of adrenal cells with GIP stimulates cortisol secretion in GIP-dependent, but not in normal fetal, adult, or non-food-dependent Cushing\u2019s syndrome, adrenals. We conclude that the GIPR overexpression and its coupling to steroidogenesis underlie GIP-dependent Cushing\u2019s syndrome.<\/jats:p>","DOI":"10.1210\/jcem.83.8.5038","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:03:29Z","timestamp":1389200609000},"page":"2781-2785","source":"Crossref","is-referenced-by-count":29,"title":["Adrenocortical Overexpression of Gastric Inhibitory Polypeptide Receptor Underlies Food-Dependent Cushing\u2019s Syndrome1"],"prefix":"10.1210","volume":"83","author":[{"given":"Nina","family":"N\u2019Diaye","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Department of Medicine, Research Center, Campus Ho\u0302tel-Dieu, Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al, Montreal, Canada H2W 1T8; and the Department of Internal Medicine, University Hospital Rotterdam (W.W.D.H.), Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Department of Medicine, Research Center, Campus Ho\u0302tel-Dieu, Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al, Montreal, Canada H2W 1T8; and the Department of Internal Medicine, University Hospital Rotterdam (W.W.D.H.), Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Hamet","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Department of Medicine, Research Center, Campus Ho\u0302tel-Dieu, Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al, Montreal, Canada H2W 1T8; and the Department of Internal Medicine, University Hospital Rotterdam (W.W.D.H.), Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter W.","family":"De Herder","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Department of Medicine, Research Center, Campus Ho\u0302tel-Dieu, Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al, Montreal, Canada H2W 1T8; and the Department of Internal Medicine, University Hospital Rotterdam (W.W.D.H.), Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Department of Medicine, Research Center, Campus Ho\u0302tel-Dieu, Centre Hospitalier de l\u2019Universite\u0301 de Montre\u0301al, Montreal, Canada H2W 1T8; and the Department of Internal Medicine, University Hospital Rotterdam (W.W.D.H.), Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071615002296400_R1","author":"Nieman","year":"1995"},{"key":"2020071615002296400_R2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/eje.0.1310067","article-title":"ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing\u2019s syndrome with major diagnostic and therapeutic implications.","volume":"131","author":"Lieberman","year":"1994","journal-title":"Eur J Clin Endocrinol"},{"key":"2020071615002296400_R3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1172\/JCI118467","article-title":"Carney complex, a familial multiple neoplasia and lentiginosis syndrome. 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