{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:50:40Z","timestamp":1772916640655,"version":"3.50.1"},"reference-count":17,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>GnRH agonists improve final height in girls with \u201ctrue\u201d precocious puberty. To test if a comparable effect can be obtained in older girls, we performed a long-term controlled study in 30 caucasian girls whose puberty started between 8.4 and 10 yr (9.4 \u00b1 0.1 yr), a variant of normal called \u201cadvanced\u201d puberty. At entry into trial, these girls had clinical, biological, and sonographic manifestations of puberty and a bone age greater than 10.9 yr. They were randomized 2:1 to receive 3.75 mg triptorelin im every 4 weeks for 2 yr (n = 20, group I) or no treatment (n = 10, group II). Mean height at inclusion was 135.2 \u00b1 4.3 cm (+0.6 sds) in group I, 136.1 \u00b1 4.2 cm (+0.8 sds ) in group II, with target height 157.6 \u00b1 4.3 cm (group I) and 157.8 \u00b1 4.7 cm (group II), and predicted height (Bayley-Pinneau) 154.1 \u00b1 3.9 cm and 155.2 \u00b1 3.7 cm. Although GnRH agonists transiently delayed sexual maturation as well as bone age and growth rate, they had no clear-cut long-standing effect, and final height was comparable in treated (157.6 \u00b1 4.0 cm) and untreated girls (156.1 \u00b1 5.3 cm) (NS).<\/jats:p>","DOI":"10.1210\/jcem.84.10.6032","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:03:58Z","timestamp":1389200638000},"page":"3575-3578","source":"Crossref","is-referenced-by-count":69,"title":["Lack of Effect of GnRH Agonists on Final Height in Girls with Advanced Puberty: A Randomized Long-Term Pilot Study"],"prefix":"10.1210","volume":"84","author":[{"given":"C.","family":"Bouvattier","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology (C.B., D.R.R., C.T., J.C.C., J.L.C., P.F.B.), Paris, France 75014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Coste","sequence":"additional","affiliation":[{"name":"Biostatistics (J.C.), Ho\u0302pital Cochin-Saint Vincent de Paul, Paris, France 75014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology (C.B., D.R.R., C.T., J.C.C., J.L.C., P.F.B.), Paris, France 75014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Teinturier","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology (C.B., D.R.R., C.T., J.C.C., J.L.C., P.F.B.), Paris, France 75014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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