{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:37:31Z","timestamp":1791286651018,"version":"4.1.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stimulation of cortisol secretion by food intake has been implicated in the pathogenesis of some cases of ACTH-independent Cushing\u2019s syndrome, via an aberrant response of the adrenal glands to gastric inhibitory polypeptide (GIP). We report here a novel case of food-dependent Cushing\u2019s syndrome in a patient with bilateral macronodular adrenal hyperplasia. In this patient we were able to confirm a paradoxical stimulation of cortisol secretion by GIP in vivo as well as in vitro on dispersed tumor adrenal cells obtained at surgery. In addition to GIP, in vitro stimulation of these cultured tumor adrenal cells with leptin, the secreted product of the adipocyte, induced cortisol secretion. By comparison, no such stimulation was observed in vitro in adrenal cells obtained from another patient with bilateral macronodular adrenal hyperplasia and Cushing\u2019s syndrome that did not depend on food intake, in tumor cells obtained from a solitary cortisol-secreting adrenal adenoma, and in normal human adrenocortical cells.<\/jats:p>\n                  <jats:p>These results demonstrate that as in previously described cases of food-dependent Cushing\u2019s syndrome, GIP stimulated cortisol secretion from the adrenals of the patient reported here. Therefore, they indicate that such a paradoxical response probably represents the hallmark of this rare condition. In addition, they suggest that leptin, which normally inhibits stimulated cortisol secretion in humans, participated in cortisol hypersecretion in this case. Further studies in other cases of food-dependent Cushing\u2019s syndrome, however, will be necessary to better ascertain the pathophysiological significance of this finding.<\/jats:p>","DOI":"10.1210\/jcem.84.10.6068","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:03:58Z","timestamp":1389182638000},"page":"3817-3822","source":"Crossref","is-referenced-by-count":9,"title":["Food-Dependent Cushing\u2019s Syndrome: Possible Involvement of Leptin in Cortisol Hypersecretion*"],"prefix":"10.1210","volume":"84","author":[{"given":"Franc\u0327ois P.","family":"Pralong","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetology, and Metabolism, Department of Medicine, Institute of Pathology (F.M.), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulgencio","family":"Gomez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology, and Metabolism, Department of Medicine, Institute of Pathology (F.M.), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Guillou","sequence":"additional","affiliation":[{"name":"the Department of Surgery (L.G.), University Hospital and Lausanne Medical School, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Mosimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Franscella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf C.","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071614141892800_R1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1056\/NEJM199503233321207","article-title":"Cushing\u2019s 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