{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:07:22Z","timestamp":1787152042964,"version":"build-2736575974"},"reference-count":43,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,11,1]]},"DOI":"10.1210\/jcem.84.11.6163","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:04:07Z","timestamp":1389200647000},"page":"4165-4171","source":"Crossref","is-referenced-by-count":5,"title":["Progesterone Metabolism in the Human Kidney and Inhibition of 11\u03b2-Hydroxysteroid Dehydrogenase Type 2 by Progesterone and Its Metabolites1"],"prefix":"10.1210","volume":"84","author":[{"given":"Marcus","family":"Quinkler","sequence":"first","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Johanssen","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gro\u00dfmann","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Ba\u0308hr","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Mu\u0308ller","sequence":"additional","affiliation":[{"name":"Urology (M.M.), Universita\u0308tsklinikum Benjamin Franklin, Freie Universita\u0308t Berlin, 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Oelkers","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Diederich","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (M.Q., S.J., C.G., V.B., W.O. S.D.), 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122111652200_R1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"2019041122111652200_R2","doi-asserted-by":"crossref","first-page":"E601","DOI":"10.1152\/ajpendo.1996.270.4.E601","article-title":"Progesterone binding to mineralocorticoid receptors: In vitro and in vivo studies","volume":"270","author":"Myles","year":"1996","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"2019041122111652200_R3","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1210\/jcem-15-10-1194","article-title":"The metabolic effects of progesterone in man.","volume":"15","author":"Landau","year":"1955","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R4","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1210\/endo-102-6-1686","article-title":"Antimineralocorticoid action of progesterone in the rat: correlation of the effect on electrolyte excretion and interaction with renal mineralocorticoid receptors.","volume":"102","author":"Wambach","year":"1978","journal-title":"Endocrinology"},{"key":"2019041122111652200_R5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0039-128X(96)00007-4","article-title":"Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure.","volume":"61","year":"1996","journal-title":"Steroids"},{"key":"2019041122111652200_R6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00016347109157335","article-title":"Progesterone levels in amniotic fluid and plasma from women. I. Levels during normal pregnancy.","volume":"50","author":"Johansson","year":"1971","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2019041122111652200_R7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1210\/jcem-29-3-352","article-title":"Transcortin: a corticosteroid-binding protein of plasma. X. Cortisol and progesterone interplay and unbound levels of these steroids in pregnancy.","volume":"29","author":"Rosenthal","year":"1969","journal-title":"J Clin Endocrinol"},{"key":"2019041122111652200_R8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0002-9378(78)90777-9","article-title":"Desoxycorticosterone in normal pregnancy. I. Sequential studies of the secretory patterns of desoxycorticosterone, aldosterone, and cortisol.","volume":"132","author":"Nolten","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122111652200_R9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.2845584","article-title":"Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.","volume":"242","author":"Funder","year":"1988","journal-title":"Science"},{"key":"2019041122111652200_R10","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(88)90742-8","article-title":"Localization of 11\u03b2-hydroxy-steroid dehydrogenase\u2013tissue-specific protector of the mineralocorticoid receptor.","volume":"2","author":"Edwards","year":"1988","journal-title":"Lancet"},{"key":"2019041122111652200_R11","author":"Morita","year":"1996"},{"key":"2019041122111652200_R12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0039-128X(96)00208-5","article-title":"Selective inhibition of sheep kidney 11\u03b2-hydroxysteroid dehydrogenase isoform 2 activity by 5\u03b1-reduced (but not 5\u03b2) derivatives of adrenocorticosteroids.","volume":"62","author":"Latif","year":"1997","journal-title":"Steroids"},{"key":"2019041122111652200_R13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1042\/bj3131007","article-title":"Cloning and production of antisera to human placental 11\u03b2-hydroxysteroid dehydrogenase type 2.","volume":"313","author":"Brown","year":"1996","journal-title":"Biochem J"},{"key":"2019041122111652200_R14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/eje.0.1340301","article-title":"Human kidney 11\u03b2-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin?","volume":"134","author":"Diederich","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"2019041122111652200_R15","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1210\/endo-123-5-2390","article-title":"Purification and characterization of the corticosteroid 11\u03b2-dehydrogenase component of the rat liver 11\u03b2-hydroxysteroid dehydrogenase complex.","volume":"123","author":"Lakshmi","year":"1988","journal-title":"Endocrinology"},{"key":"2019041122111652200_R16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0960-0760(93)90153-N","article-title":"Metabolism of progesterone and testosterone in human parotid and submandibular salivary glands in vitro.","volume":"44","author":"Blom","year":"1993","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041122111652200_R17","first-page":"Suppl","article-title":"Studies on the anomalous behavior of steroids in absorption chromatography","volume":"55","author":"Nienstedt","year":"1967","journal-title":"Acta Endocrinol Copenh."},{"key":"2019041122111652200_R18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0021-9673(01)81912-9","article-title":"Characterization of C19 steroids by two-dimensional thin-layer chromatography.","volume":"329","year":"1985","journal-title":"J Chromatogr"},{"key":"2019041122111652200_R19","first-page":"1598","article-title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11\u03b2-reduction.","volume":"82","author":"Diederich","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1210\/jcem-53-1-58","article-title":"Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.","volume":"53","author":"Dunn","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R21","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1210\/endo.136.12.7588320","article-title":"The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.","volume":"136","author":"Souque","year":"1995","journal-title":"Endocrinology"},{"key":"2019041122111652200_R22","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1073\/pnas.77.12.7069","article-title":"Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action.","volume":"77","author":"Winkel","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122111652200_R23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/jcem-53-1-10","article-title":"Deoxycorticosterone biosynthesis from progesterone in kidney tissue of the human fetus.","volume":"53","author":"Winkel","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0039-128X(83)90041-7","article-title":"Conversion of progesterone to corticosteroids by the midterm fetal adrenal and kidney.","volume":"42","author":"McShane","year":"1983","journal-title":"Steroids"},{"key":"2019041122111652200_R25","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/jcem-53-5-990","article-title":"Deoxycorticosterone sulfate biosynthesis in human fetal kidney.","volume":"53","author":"Casey","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R26","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0022-4731(80)90053-9","article-title":"Metabolism of progesterone, 17-hydroxyprogesterone and deoxycorticosterone by human small intestine in vitro.","volume":"13","author":"Nienstedt","year":"1980","journal-title":"J Steroid Biochem"},{"key":"2019041122111652200_R27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0022-4731(85)90063-9","article-title":"Metabolism of progesterone by healthy and inflamed human gingiva in vitro.","volume":"23","year":"1985","journal-title":"J Steroid Biochem"},{"key":"2019041122111652200_R28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1507\/endocrj1954.14.232","article-title":"Progesterone metabolism by human fetal and placental tissues: interconversion of progesterone and 20-\u03b1-hydroxypregn-4-en-3-one in the feto-placental unit in vitro.","volume":"14","author":"Maeyama","year":"1967","journal-title":"Endocrinol Jpn"},{"key":"2019041122111652200_R29"},{"key":"2019041122111652200_R30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1440-1681.1982.tb00792.x","article-title":"The affinity of 17\u03b1-hydroxyprogesterone and 17\u03b1,20\u03b1-dihydroxyprogesterone for classical mineralocorticoid or glucocorticoid receptors.","volume":"9","author":"Butkus","year":"1982","journal-title":"Clin Exp Pharm Physiol"},{"key":"2019041122111652200_R31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0022-4731(78)90098-5","article-title":"The affinity of hydroxylated progesterone derivates for classical steroid receptors.","volume":"9","author":"Mercer","year":"1978","journal-title":"J Steroid Biochem"},{"key":"2019041122111652200_R32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/jcem-48-1-133","article-title":"Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies. I. C21 steroids: progesterone, 16\u03b1 -hydroxyprogesterone:17 \u03b1-hydroxyprogesterone, 20\u03b1 -dihydroprogesterone, \u03b4 5-pregnenolone, \u03b4 5-pregnenolone sulfate, and 17-hydroxy \u03b4 5-pregnenolone.","volume":"48","author":"Buster","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/ajh\/5.6.366","article-title":"Renin-aldosterone relationships in pregnancy-induced hypertension.","volume":"5","author":"Brown","year":"1992","journal-title":"Am J Hypertens"},{"key":"2019041122111652200_R34","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1210\/jcem.74.4.1312541","article-title":"Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension.","volume":"74","author":"Wacker","year":"1992","journal-title":"J Clin Endocrin Metabol"},{"key":"2019041122111652200_R35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1034\/j.1600-0412.1998.770606.x","article-title":"Plasma renin activity and aldosterone serum concentration are decreased in severe preeclampsia but not in the HELLP-syndrome.","volume":"77","author":"Bussen","year":"1998","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2019041122111652200_R36","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/0002-9378(90)90639-O","article-title":"Longitudinal study of the renin-angiotensin-aldosterone system in hypertensive pregnant women: deviations related to the development of superimposed preeclampsia.","volume":"163","author":"August","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122111652200_R37","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0002-9378(70)90335-2","article-title":"Plasma cortisol levels and cortisol binding in normal and pre-eclamptic pregnancies.","volume":"108","author":"Kopelman","year":"1970","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122111652200_R38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1210\/jcem-35-5-736","article-title":"Plasma deoxycorticosterone in normal and abnormal human pregnancy.","volume":"35","author":"Brown","year":"1972","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R39","first-page":"222","article-title":"Progesterone and estradiol production by normal and preeclamptic placentas.","volume":"71","year":"1988","journal-title":"Obstet Gynecol"},{"key":"2019041122111652200_R40","first-page":"161","article-title":"Quantitative determination of 17-estradiol and progesterone in cellular fractions of term placentae of normal and hypertensive patients.","volume":"77","author":"Bhansali","year":"1992","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"2019041122111652200_R41","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/jcem.74.4.1312543","article-title":"Mineralocorticoid effector mechanism in preeclampsia.","volume":"74","author":"Armanini","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122111652200_R42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1161\/01.HYP.25.4.626","article-title":"11\u03b2-hydroxysteroid dehydrogenase and its inhibitors in hypertensive pregnancy.","volume":"25","author":"Walker","year":"1995","journal-title":"Hypertension"},{"key":"2019041122111652200_R43"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/84\/11\/4165\/9216927\/jcem4165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T15:36:59Z","timestamp":1555083419000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/84\/11\/4165\/2864627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,1]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.84.11.6163","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,1]]}}}