{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:50:28Z","timestamp":1648608628197},"reference-count":27,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:p>Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI polymorphism causes different lengths of the VDR, implying possible functional consequences. The VDR-FokI polymorphism was studied in 182 postmenopausal women with sporadic PHPT and in matched controls. No significant differences in distribution of the VDR-FokI genotypes could be detected between the groups, although there was a tendency toward overrepresentation of the F allele in the PHPT patients (P = 0.05). There were no significant associations with age, serum calcium, serum PTH, bone mineral density, or parathyroid tumor weight. The VDR genotypes were unrelated to VDR and PTH messenger ribonucleic acid levels in the parathyroid adenomas of 42 PHPT patients. In 23 PHPT patients, the Ca2+-PTH set-points were determined in vivo and were unrelated to the VDR alleles. We suggest that the VDR-FokI polymorphism has at most a minor pathogenic importance in the development of PHPT.<\/jats:p>","DOI":"10.1210\/jcem.84.5.5707","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:04:37Z","timestamp":1389200677000},"page":"1690-1694","source":"Crossref","is-referenced-by-count":0,"title":["The Vitamin D Receptor (VDR) Start Codon Polymorphism in Primary Hyperparathyroidism and Parathyroid VDR Messenger Ribonucleic Acid Levels1"],"prefix":"10.1210","volume":"84","author":[{"given":"Pamela","family":"Correa","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schwarz","sequence":"additional","affiliation":[{"name":"the Department of Medicine (P.S.), Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Westin","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kindmark","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.K.), Uppsala University Hospital, S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go\u0308ran","family":"A\u030akerstro\u0308m","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Carling","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery (P.C., J.R., G.W., E.L., G.A\u030a., T.C.), S-751 85 Uppsala, SwedenM"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071620423463400_R1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2362.1988.tb01163.x","article-title":"Prevalence of hypercalcemia in a health survey: a fourteen-year follow-up study of serum calcium values.","volume":"18","author":"Palme\u0301r","year":"1988","journal-title":"Eur J Clin Invest"},{"key":"2020071620423463400_R2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0039-6060(97)90357-3","article-title":"Population-based health screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women.","volume":"121","author":"Lundgren","year":"1997","journal-title":"Surgery"},{"key":"2020071620423463400_R3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF02555137","article-title":"1,25(OH)2D3 inhibits hormone secretion and proliferation but not functional dedifferentiation of cultured bovine parathyroid cells.","volume":"43","author":"Nygren","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"2020071620423463400_R4","first-page":"175","article-title":"Regulation of parathyroid hormone synthesis and secretion.","volume":"14","author":"Silver","year":"1994","journal-title":"Semin Nephrol"},{"key":"2020071620423463400_R5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1677\/joe.0.1230137","article-title":"Effects of 1,25-dihydroxyvitamin D3 and cortisol on bovine and human parathyroid cells.","volume":"123","author":"Karmali","year":"1989","journal-title":"J Endocrinol"},{"key":"2020071620423463400_R6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1172\/JCI116720","article-title":"Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients.","volume":"92","author":"Fukuda","year":"1993","journal-title":"J Clin Invest"},{"key":"2020071620423463400_R7"},{"key":"2020071620423463400_R8","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/nm1295-1309","article-title":"Vitamin D receptor genotypes in primary hyperparathyroidism.","volume":"1","author":"Carling","year":"1995","journal-title":"Nat Med"},{"key":"2020071620423463400_R9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/bbrc.1997.6086","article-title":"Vitamin D receptor alleles b, a and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1.","volume":"231","author":"Carling","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071620423463400_R10"},{"key":"2020071620423463400_R11","first-page":"1772","article-title":"Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism.","volume":"82","author":"Carling","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071620423463400_R12","first-page":"2255","article-title":"Vitamin D receptor (VDR) and parathyroid hormone mRNA levels correspond to polymorphic VDR alleles in human parathyroid tumors.","volume":"83","author":"Carling","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071620423463400_R13","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1073\/pnas.85.10.3294","article-title":"Cloning and expression of full-length cDNA encoding human vitamin D receptor.","volume":"85","author":"Baker","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071620423463400_R14","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/jbmr.5650111204","article-title":"The presence of a polymorphism at the translation initiation site of the vitamin D receptor is associated with low bone mineral density in postmenopausal Mexican-American women.","volume":"11","author":"Gross","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2020071620423463400_R15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/367284a0","article-title":"Prediction of bone density from vitamin D receptor alleles.","volume":"367","author":"Morrison","year":"1994","journal-title":"Nature"},{"key":"2020071620423463400_R16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1359\/jbmr.1998.13.1.31","article-title":"Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: the OFELY study.","volume":"13","author":"Eccleshall","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2020071620423463400_R17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1359\/jbmr.1997.12.7.1043","article-title":"The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women.","volume":"12","author":"Harris","year":"1997","journal-title":"J Bone Miner Res"},{"key":"2020071620423463400_R18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.1997.12.6.915","article-title":"A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women.","volume":"12","author":"Arai","year":"1997","journal-title":"J Bone Miner Res"},{"key":"2020071620423463400_R19","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2362.1993.tb00964.x","article-title":"Cica-clamp technique: a method for quantifying parathyroid hormone secretion: a sequential citrate and calcium clamp study.","volume":"23","author":"Schwarz","year":"1993","journal-title":"Eur J Clin Invest"},{"key":"2020071620423463400_R20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2362.1994.tb01106.x","article-title":"Inter-relations between the calcium set-points of Parfitt and Brown in primary hyperparathyroidism: a sequential citrate and calcium clamp study.","volume":"24","author":"Schwarz","year":"1994","journal-title":"Eur J Clin Invest"},{"key":"2020071620423463400_R21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0039-6060(97)90214-2","article-title":"Estrogen receptor gene polymorphism in postmenopausal primary hyperparathyroidism.","volume":"122","author":"Carling","year":"1997","journal-title":"Surgery"},{"key":"2020071620423463400_R22","author":"Arnold","year":"1994"},{"key":"2020071620423463400_R23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1359\/jbmr.1998.13.6.925","article-title":"Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary calcium, and 3\u2032-end region polymorphisms.","volume":"13","author":"Ferrari","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2020071620423463400_R24"},{"key":"2020071620423463400_R25","first-page":"93","article-title":"Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies.","volume":"6","author":"Ingles","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2020071620423463400_R26"},{"key":"2020071620423463400_R27","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1210\/endo.136.4.7895652","article-title":"The roles of calcium and 1,25-dihydroxyvitamin D3 in the regulation of vitamin D receptor expression by rat parathyroid glands.","volume":"136","author":"Brown","year":"1995","journal-title":"Endocrinology"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/84\/5\/1690\/9215565\/jcem1690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/84\/5\/1690\/9215565\/jcem1690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T05:36:54Z","timestamp":1594964214000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/84\/5\/1690\/2864357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.84.5.5707","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5,1]]}}}