{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:40:28Z","timestamp":1790541628991,"version":"4.1.0"},"reference-count":36,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it would be of great benefit to predict the response of the patients to FSH. To date, no clear-cut predictors of ovarian responsiveness to FSH have been identified. In this study, we investigated the role of two distinct FSH receptor (FSHR) variants, Thr307\/Asn680 and Ala307\/Ser680, in the response to FSH in women undergoing controlled ovarian stimulation.<\/jats:p>\n               <jats:p>The FSHR polymorphism at position 680 was analyzed by restriction-fragment-length polymorphism in 161 ovulatory women below the age of 40 yr. With reference to the couple, infertility has been diagnosed as being attributable to male causes (76%), tubal factor (11%), or both (13%). The distribution was 29% for the Asn\/Asn, 45% for the Asn\/Ser, and 26% for the Ser\/Ser FSHR variant. Peak estradiol levels, number of preovulatory follicles, and number of retrieved oocytes were similar in the 3 groups. However, basal FSH levels were significantly different among the 3 groups (6.4 \u00b1 0.4 IU\/L, 7.9 \u00b1 0.3 IU\/L, and 8.3 \u00b1 0.6 IU\/L for the Asn\/Asn, Asn\/Ser, and Ser\/Ser groups, respectively, P &amp;lt; 0.01). The number of FSH ampoules required for successful stimulation was significantly different among the 3 groups (31.8 \u00b1 2.4, 40.7 \u00b1 2.3, and 46.8 \u00b1 5.0 for the Asn\/Asn, Asn\/Ser, and Ser\/Ser groups, respectively, P &amp;lt; 0.05). According to multiple linear regression analysis, the number of ampoules needed could be predicted from a linear combination of both the type of polymorphism and basal FSH levels (P &amp;lt; 0.001).<\/jats:p>\n               <jats:p>These clinical findings demonstrate that the ovarian response to FSH stimulation depends on the FSHR genotype.<\/jats:p>","DOI":"10.1210\/jcem.85.9.6789","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:06:07Z","timestamp":1389200767000},"page":"3365-3369","source":"Crossref","is-referenced-by-count":42,"title":["Ovarian Response to Follicle-Stimulating Hormone (FSH) Stimulation Depends on the FSH Receptor Genotype*"],"prefix":"10.1210","volume":"85","author":[{"given":"Maritza Perez","family":"Mayorga","sequence":"first","affiliation":[{"name":"Institute of Reproductive Medicine (M.P.M., J.G., E.N., M.S.), D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rg","family":"Gromoll","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (M.P.M., J.G., E.N., M.S.), D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann M.","family":"Behre","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (H.M.B., C.G.) of the University, D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Gassner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (H.M.B., C.G.) of the University, D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Nieschlag","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (M.P.M., J.G., E.N., M.S.), D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Simoni","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine (M.P.M., J.G., E.N., M.S.), D-48129 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071614173893000_R1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0962279900001150","article-title":"FSH in therapy: physiological basis, new preparations and clinical use","volume":"4","author":"Simoni","year":"1995","journal-title":"Reprod Med Rev."},{"key":"2020071614173893000_R2","first-page":"739","article-title":"The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology","volume":"18","author":"Simoni","year":"1997","journal-title":"Endocr 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Steril."},{"key":"2020071614173893000_R6","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1210\/mend.13.11.0370","article-title":"New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype","volume":"13","author":"Touraine","year":"1999","journal-title":"Mol Endocrinol."},{"key":"2020071614173893000_R7","first-page":"751","article-title":"Mutational analysis of the follicle-stimulating hormone receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms","volume":"84","author":"Simoni","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"2020071614173893000_R8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0015-0282(98)00151-4","article-title":"Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic 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Hum Reprod."},{"key":"2020071614173893000_R11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/humrep\/12.6.1129","article-title":"The pathophysiology of ovarian hyperstimulation syndrome \u2014 views and ideas","volume":"12","author":"Elchalal","year":"1997","journal-title":"Hum Reprod."},{"key":"2020071614173893000_R12","first-page":"118","article-title":"Follicle-stimulating hormone as a predictor of fertility","volume":"19","author":"Barnhart","year":"1998","journal-title":"Curr Opin Obstet Gynecol."},{"key":"2020071614173893000_R13","first-page":"539","article-title":"A prospective evaluation of clomiphene citrate challenge test screening in the general infertility population","volume":"82","author":"Scott","year":"1993","journal-title":"Obstet Gynecol."},{"key":"2020071614173893000_R14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(16)57287-2","article-title":"Prognostic assessment of ovarian 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between maximum early follicular phase serum follicle-stimulating hormone levels and menstrual cycle characteristics in women under the age of 35 years","volume":"13","author":"Schipper","year":"1998","journal-title":"Hum Reprod."},{"key":"2020071614173893000_R35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/edrv-10-2-205","article-title":"Intragonadal regulation of follicular maturation","volume":"10","author":"Tonetta","year":"1989","journal-title":"Endocr Rev."},{"key":"2020071614173893000_R36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1071\/RD9940127","article-title":"Peripheral and local regulators of folliculogenesis","volume":"6","author":"Findlay","year":"1994","journal-title":"Reprod Fertil Dev."}],"container-title":["The Journal of Clinical Endocrinology &amp; 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