{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:20:10Z","timestamp":1779924010595,"version":"3.53.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:p>We report 98 children who have reached final adult height in a long-term trial of LHRH agonist treatment. These children were 5.3\u00b1 2.1 yr old at the start of treatment and were treated with either deslorelin (4 \u03bcg\/kg\u00b7d sc) or histrelin (4\u201310 \u03bcg\/kg\u00b7d) for an average of 6.1 \u00b1 2.5 yr. Final height averaged 159.8 \u00b1 7.6 cm in the 80 girls, which was significantly greater than pretreatment predicted height (149.3 \u00b1 9.6 cm) but still significantly less than midparental height (MPH) (163.7 \u00b1 5.6). Final height averaged 171.1 \u00b1 8.7 cm in the 18 boys, which was significantly greater than pretreatment predicted height (156.1 \u00b1 14.2 cm) but still significantly less than MPH (178.3 \u00b1 5.2 cm). However, the average adult height of the 54 children who had less than a 2-yr delay in the onset of treatment was not significantly different from their MPH, and 21 children exceeded MPH.<\/jats:p>\n               <jats:p>Final height sd score correlated positively with duration of treatment (P &amp;lt; 0.01), midparental height (P &amp;lt; 0.001), predicted height at the start of treatment (P &amp;lt; 0.001), and growth velocity during the last year of treatment (P &amp;lt; 0.001) and correlated inversely with delay in the onset of treatment (P &amp;lt; 0.001), age at the start of treatment (P &amp;lt; 0.001), bone age at the start of treatment (P &amp;lt; 0.001), bone age at the end of treatment (P &amp;lt; 0.001), breast stage at the start of treatment (P = 0.02), and bone age minus chronological age at the start of treatment (P = 0.001).<\/jats:p>\n               <jats:p>We conclude that LHRH agonist treatment improves the final height for children with rapidly progressing precocious puberty treated before the age of 8 yr for girls or 9 yr for boys. Less delay in the onset of treatment, longer duration of treatment, and lower chronological and bone age at the onset of treatment all lead to greater final height. All children with onset of pubertal symptoms before age 8 in girls and age 9 in boys should be evaluated for possible treatment. Treatment is appropriate in children with rapidly progressing puberty, accelerated bone maturation, and compromise of adult height prediction, regardless of bone age or chronological age at time of evaluation. However, once treatment is considered appropriate, it should be initiated quickly, because longer delays lead to shorter final height. In addition, the longer the treatment is continued, the greater is the final height outcome.<\/jats:p>","DOI":"10.1210\/jcem.86.10.7915","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:06:15Z","timestamp":1389200775000},"page":"4711-4716","source":"Crossref","is-referenced-by-count":132,"title":["Increased Final Height in Precocious Puberty after Long-Term Treatment with LHRH Agonists: The National Institutes of Health Experience"],"prefix":"10.1210","volume":"86","author":[{"given":"Karen Oerter","family":"Klein","sequence":"first","affiliation":[{"name":"Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet V.","family":"Jones","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope P.","family":"Feuillan","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon B.","family":"Cutler Jr.","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071618052658500_R1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/jcem-71-4-785","article-title":"Clinical Review 14: Pathophysiology and treatment of sexual precocity.","volume":"71","author":"Kaplan","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071618052658500_R2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.med.45.1.391","article-title":"Gonadotropin-releasing hormone and its analogs.","volume":"45","author":"Conn","year":"1994","journal-title":"Annu Rev Med"},{"key":"2020071618052658500_R3","first-page":"223","article-title":"Advances in the treatment of precocious puberty.","volume":"41","author":"Kappy","year":"1994","journal-title":"Adv Pediatr"},{"issue":"Suppl 1","key":"2020071618052658500_R4","first-page":"841","article-title":"Neurofibromatosis type 1 and precocious puberty","volume":"13","author":"Virdis","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"Suppl 1","key":"2020071618052658500_R5","first-page":"787","article-title":"Near final height after GnRH agonist treatment in central precocious puberty","volume":"13","author":"Micillo","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2020071618052658500_R6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/adc.81.4.329","article-title":"Randomized trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5\u20138.5 years.","volume":"81","author":"Cassio","year":"1999","journal-title":"Arch Dis Child"},{"key":"2020071618052658500_R7","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/jcem.84.10.6032","article-title":"Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study.","volume":"84","author":"Bouvattier","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2020071618052658500_R8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1515\/JPEM.2000.13.S1.765","article-title":"Final height after gonadotropin releasing hormone agonist treatment for central precocious puberty: the Dutch experience","volume":"13","author":"Mul","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"Suppl 1","key":"2020071618052658500_R9","first-page":"747","article-title":"Treatment of central precocious puberty: lessons from a 15 years prospective trial","volume":"13","author":"Partsch","year":"2000","journal-title":"German Decapeptyl Study Group. 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