{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:51:25Z","timestamp":1790905885750,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:p>We analyzed the final height of 146 short children with either nonacquired GH deficiency or idiopathic short stature. Our purpose was 1) to assess growth according to the pituitary magnetic resonance imaging findings in the 63 GH-treated children with GH deficiency and 2) to compare the growth of the GH-deficient patients with normal magnetic resonance imaging (n = 48) to that of 32 treated and 51 untreated children with idiopathic short stature (GH peak to provocative tests &amp;gt;10 \u03bcg\/liter). The mean GH dose was 0.44 IU\/kg\u00b7wk (0.15 mg\/kg\u00b7wk), given for a mean duration of 4.6 yr.<\/jats:p><jats:p>Among the GH-deficient children, 15 had hypothalamic-pituitary abnormalities (stalk agenesis), all with total GH deficiency (GH peak&amp;lt;5 \u03bcg\/liter). They were significantly shorter and younger at the time of diagnosis than those with normal magnetic resonance imaging, had better catch-up growth (+2.7 \u00b1 0.9 vs.+ 1.3 \u00b1 0.8 sd score; P &amp;lt; 0.01), and reached greater final height (\u22121.1 \u00b1 1.0 vs.\u2212 1.7 \u00b1 1.0 sd score; P &amp;lt; 0.05). Among patients with normal magnetic resonance imaging, there was no difference in catch-up growth and final height between partial and total GH deficiencies.<\/jats:p><jats:p>GH-deficient subjects with normal magnetic resonance imaging and treated and untreated patients with idiopathic short stature had comparable auxological characteristics, age at evaluation, and target height. Although they had different catch-up growth (+1.3 \u00b1 0.8,+ 0.9 \u00b1 0.6, and +0.7 \u00b1 0.9 sd score, respectively; P &amp;lt; 0.01, by ANOVA), these patients reached a similar final height (\u22121.7 \u00b1 1.0, \u22122.1 \u00b1 0.8, and \u22122.1 \u00b1 1.0 sd score, respectively; P = 0.13).<\/jats:p><jats:p>Pituitary magnetic resonance imaging findings show the heterogeneity within the group of nonacquired GH deficiency and help to predict the response to GH treatment in these patients. The similarities in growth between the GH-deficient children with normal magnetic resonance imaging and those with idiopathic short stature suggest that the short stature in the former subjects is at least partly due to factors other than GH deficiency.<\/jats:p>","DOI":"10.1210\/jcem.86.10.7962","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:06:15Z","timestamp":1389200775000},"page":"4649-4654","source":"Crossref","is-referenced-by-count":51,"title":["Growth and Adult Height in GH-Treated Children with Nonacquired GH Deficiency and Idiopathic Short Stature: The Influence of Pituitary Magnetic Resonance Imaging Findings"],"prefix":"10.1210","volume":"86","author":[{"given":"Re\u0301gis","family":"Coutant","sequence":"first","affiliation":[{"name":"Departments of Pediatrics (R.C., S.R., J.M.L.), 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phanie","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (R.C., S.R., J.M.L.), 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Despert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital (F.D., N.M.), 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Magontier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital (F.D., N.M.), 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Loisel","sequence":"additional","affiliation":[{"name":"Radiology (D.L.), University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Limal","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (R.C., S.R., J.M.L.), 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071621010749300_R1","first-page":"1532","article-title":"Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited.","volume":"80","author":"Rosenfeld","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1210\/jcem.82.2.3841","article-title":"Is growth hormone deficiency a viable diagnosis [Editorial ]?","volume":"82","author":"Rosenfeld","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl","key":"2020071621010749300_R3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1651-2227.1991.tb12052.x","article-title":"The Kabi Pharmacia International Growth Study: aetiology classification list with comments","volume":"379","author":"Ranke","year":"1991","journal-title":"Acta Paediatr Scand"},{"key":"2020071621010749300_R4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1203\/00006450-199602000-00018","article-title":"Spontaneous growth and response to growth hormone treatment in children with growth hormone deficiency and idiopathic short stature.","volume":"39","author":"Wit","year":"1996","journal-title":"Pediatr Res"},{"key":"2020071621010749300_R5","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1210\/jcem.84.12.6189","article-title":"Four decades of growth hormone therapy for short children: what have we achieved?","volume":"84","author":"Guyda","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1148\/radiology.165.2.3659371","article-title":"Transection of the pituitary stalk: development of an ectopic posterior lobe assessed with MR imaging.","volume":"165","author":"Fujisawa","year":"1987","journal-title":"Radiology"},{"key":"2020071621010749300_R7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1210\/jcem-67-4-817","article-title":"Hypothalamic-pituitary function in growth hormone-deficient patients with pituitary stalk transection.","volume":"67","author":"Kikuchi","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0022-3476(05)81955-9","article-title":"Magnetic resonance imaging in the diagnosis of growth hormone deficiency.","volume":"120","author":"Argyropoulou","year":"1992","journal-title":"J Pediatr"},{"key":"2020071621010749300_R9","first-page":"3450","article-title":"Pituitary-stalk interruption syndrome: a clinical-biological-genetic assessment of its pathogenesis.","volume":"82","author":"Pinto","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1210\/jcem.84.4.5614","article-title":"Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults.","volume":"84","author":"Maghnie","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1210\/jcem.82.2.3726","article-title":"Growth hormone (GH) retesting and auxological data in 131 GH-deficient patients after completion of treatment.","volume":"82","author":"Tauber","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R12","first-page":"1663","article-title":"Value and limits of pharmacological and physiological tests to diagnose growth hormone (GH) deficiency and predict therapy response: first and second retesting during replacement therapy of patients defined as GH deficient.","volume":"79","author":"Cacciari","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R13","first-page":"1244","article-title":"Reevaluation of growth hormone (GH) secretion in 69 adults diagnosed as GH-deficient patients during childhood.","volume":"81","author":"Longobardi","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R14","author":"Sempe\u0301","year":"1979"},{"key":"2020071621010749300_R15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0022-3476(69)80224-6","article-title":"Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation.","volume":"74","author":"Usher","year":"1969","journal-title":"J Pediatr"},{"key":"2020071621010749300_R16","first-page":"13","article-title":"Body mass index variations: centiles from birth to 87 years.","volume":"45","author":"Rolland-Cachera","year":"1991","journal-title":"Eur J Clin Nutr"},{"key":"2020071621010749300_R17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in the pattern of pubertal changes in girls.","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"2020071621010749300_R18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys.","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch Dis Child"},{"key":"2020071621010749300_R19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000184851","article-title":"Towards a consensus on the definition of idiopathic short stature.","volume":"45","author":"Ranke","year":"1996","journal-title":"Horm Res"},{"key":"2020071621010749300_R20","author":"Sempe\u0301","year":"1971"},{"key":"2020071621010749300_R21","author":"Greulich","year":"1959"},{"key":"2020071621010749300_R22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Table for predicting adult height from skeletal age. Revised for use with the Greulich-Pyle hand standards.","volume":"40","author":"Bayley","year":"1952","journal-title":"J Pediatr"},{"key":"2020071621010749300_R23","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1542\/peds.104.S5.1000","article-title":"Adult height in GH deficiency: historical perspective and examples from the National Cooperative Growth Study.","volume":"104","author":"Frindik","year":"1999","journal-title":"Pediatrics"},{"key":"2020071621010749300_R24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1210\/jcem.82.2.3734","article-title":"Adult height in GH (GH)-deficient children treated with biosynthetic GH. The Genentech, Inc. Growth Study Group.","volume":"82","author":"Blethen","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000185487","article-title":"Factors determining pubertal growth and final height in GH treatment of idiopathic GH deficiency. Analysis of 195 patients of the Kabi Pharmacia International Growth Study.","volume":"48","author":"Ranke","year":"1997","journal-title":"Horm Res"},{"key":"2020071621010749300_R26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/bmj.315.7110.708","article-title":"Long-term results of GH treatment in short stature children: a population register-based study.","volume":"315","author":"Coste","year":"1997","journal-title":"Br Med J"},{"key":"2020071621010749300_R27","first-page":"574","article-title":"Factors predicting the response to GH (GH) therapy in prepubertal children with GH deficiency.","volume":"76","author":"Blethen","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R28","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/jcem.84.4.5634","article-title":"Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human GH (GH) in prepubertal children with idiopathic GH deficiency. KIGS International Board. Kabi Pharmacia International Growth Study.","volume":"84","author":"Ranke","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00441309","article-title":"Final height and pubertal development in 55 children with idiopathic GH deficiency, treated for between 2 and 15 yr with human GH.","volume":"137","author":"Burns","year":"1981","journal-title":"Eur J Pediatr"},{"key":"2020071621010749300_R30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1203\/00006450-198308000-00015","article-title":"Final height of patients with pituitary growth failure and changes in growth variables after long term hormonal therapy.","volume":"17","author":"Joss","year":"1983","journal-title":"Pediatr Res"},{"key":"2020071621010749300_R31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000184256","article-title":"Final height in children with GH deficiency.","volume":"43","author":"Bramswig","year":"1995","journal-title":"Horm Res"},{"key":"2020071621010749300_R32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00441210","article-title":"The efficacy of GH in different types of growth failure. An analysis of 101 cases.","volume":"138","author":"Lenko","year":"1982","journal-title":"Eur J Pediatr"},{"key":"2020071621010749300_R33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000184258","article-title":"Final height and pubertal development in children with GH deficiency after long-term treatment.","volume":"43","author":"Frisch","year":"1995","journal-title":"Horm Res"},{"key":"2020071621010749300_R34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000184260","article-title":"Final height in children with GH deficiency.","volume":"43","author":"Severi","year":"1995","journal-title":"Horm Res"},{"key":"2020071621010749300_R35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/jcem-69-2-221","article-title":"The influence of gonadal function and the effect of gonadal suppression treatment on final height in GH (GH)-treated GH-deficient children.","volume":"69","author":"Hibi","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R36","first-page":"537","article-title":"The effects of estrogen priming and puberty on the GH response to standardized treadmill exercise and arginine-insulin in normal girls and boys.","volume":"79","author":"Marin","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R37","first-page":"3323","article-title":"Reliability of provocative tests to assess GH secretory status. Study in 472 normally growing children.","volume":"81","author":"Ghigo","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R38","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1210\/jcem.82.7.4106","article-title":"GH testing for the diagnosis of GH deficiency in childhood: a population register based study.","volume":"82","author":"Carel","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R39","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1210\/jcem-70-5-1292","article-title":"A specific RIA for the GH (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency.","volume":"70","author":"Blum","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621010749300_R40","first-page":"65","article-title":"Magnetic resonance imaging in GH deficiency","author":"Nagel","year":"1999","journal-title":"In: Ranke MB, Wilton P, eds. GH therapy in KIGS-10 yr experience. Heidelberg, Leipzig: Barth-Verlag;"},{"key":"2020071621010749300_R41","first-page":"1743","article-title":"MR findings in hereditary isolated GH deficiency.","volume":"18","author":"Kornreich","year":"1997","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/86\/10\/4649\/9167769\/jcem4649.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/86\/10\/4649\/9167769\/jcem4649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T14:58:17Z","timestamp":1688914697000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/86\/10\/4649\/2848928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,1]]},"references-count":41,"aliases":["10.1210\/jc.86.10.4649"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.86.10.7962","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,1]]}}}