{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:35:27Z","timestamp":1785368127876,"version":"3.55.0"},"reference-count":70,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"DOI":"10.1210\/jcem.86.3.7285","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:06:16Z","timestamp":1389200776000},"page":"1026-1033","source":"Crossref","is-referenced-by-count":5,"title":["Interrelationships among Lipoprotein Levels, Sex Hormones, Anthropometric Parameters, and Age in Hypogonadal Men Treated for 1 Year with a Permeation-Enhanced Testosterone Transdermal System1"],"prefix":"10.1210","volume":"86","author":[{"given":"Adrian S.","family":"Dobs","sequence":"first","affiliation":[{"name":"The Johns Hopkins Medical Center (A.S.D., P.S.B.), Baltimore, Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Bachorik","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Medical Center (A.S.D., P.S.B.), Baltimore, Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Arver","sequence":"additional","affiliation":[{"name":"Karolinska Hospital (S.A.), Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Wayne","family":"Meikle","sequence":"additional","affiliation":[{"name":"Departments of Medicine (A.W.M.), Salt Lake City, Utah 84132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Watson Laboratories, Inc. (S.W.S., K.E.C., N.A.M.), Salt Lake City, Utah 84108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim E.","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Watson Laboratories, Inc. (S.W.S., K.E.C., N.A.M.), Salt Lake City, Utah 84108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman A.","family":"Mazer","sequence":"additional","affiliation":[{"name":"Pharmaceutics (N.A.M.), University of Utah, Salt Lake City, Utah 84132"},{"name":"Watson Laboratories, Inc. (S.W.S., K.E.C., N.A.M.), Salt Lake City, Utah 84108"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116332604300_R1","first-page":"1","article-title":"Deaths: final data for 1997.","volume":"47","author":"Hoyert","year":"1999","journal-title":"Natl Vital Stat Rep"},{"key":"2019041116332604300_R2","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1001\/jama.1986.03380200073024","article-title":"Incidence of coronary heart disease and lipoprotein cholesterol levels\u2013The Framingham Study.","volume":"256","author":"Castelli","year":"1986","journal-title":"JAMA"},{"key":"2019041116332604300_R3","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1136\/bmj.290.6477.1239","article-title":"Total and high density lipoprotein cholesterol in the serum and risk of mortality: evidence of a threshold effect.","volume":"290","author":"Goldbourt","year":"1985","journal-title":"Br Med J"},{"key":"2019041116332604300_R4","first-page":"11311","article-title":"High-density lipoprotein: the clinical implications of recent studies.","volume":"321","author":"Gordon","year":"1989","journal-title":"N Engl J Med"},{"key":"2019041116332604300_R5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0026-0495(83)90002-1","article-title":"Relationship of plasma HDL-cholesterol to testosterone, estradiol and sex-hormone-binding globulin levels in men and women.","volume":"32","author":"Semmons","year":"1983","journal-title":"Metabolism"},{"key":"2019041116332604300_R6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0531-5565(94)90017-5","article-title":"Impact of the menopause on the epidemiology and risk factors of coronary artery heart disease in women.","volume":"29","year":"1994","journal-title":"Exp Gerontol"},{"key":"2019041116332604300_R7","author":"Adams","year":"1994"},{"key":"2019041116332604300_R8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1001\/jama.1987.03390040118029","article-title":"Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence.","volume":"257","author":"Kirkland","year":"1987","journal-title":"JAMA"},{"key":"2019041116332604300_R9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/ijan.1995.18.5.237","article-title":"Testosterone enanthate at a dose of 200 mg\/week decreases HDL-cholesterol levels in healthy men.","volume":"18","author":"Meriggiola","year":"1995","journal-title":"Int J Androl"},{"key":"2019041116332604300_R10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0026-0495(87)90130-2","article-title":"The dysproteinemia of anabolic steroid therapy: increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein2 cholesterol.","volume":"36","author":"Applebaum-Bowden","year":"1987","journal-title":"Metabolism"},{"key":"2019041116332604300_R11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0021-9150(88)90014-7","article-title":"Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogonadal males.","volume":"69","author":"Sorva","year":"1988","journal-title":"Atherosclerosis"},{"key":"2019041116332604300_R12","first-page":"1092","article-title":"Effects of testosterone supplementation in the aging male.","volume":"75","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0021-9150(95)05673-4","article-title":"Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men.","volume":"121","author":"Zgliczynski","year":"1996","journal-title":"Atherosclerosis"},{"key":"2019041116332604300_R14","first-page":"3","article-title":"Effects of administration of testosterone and\/or GH in healthy aged men.","volume":"3","author":"Mu\u0308nzer","year":"2000","journal-title":"Aging Male"},{"key":"2019041116332604300_R15","first-page":"3","article-title":"The effects of transdermal testosterone on bone metabolism, body composition, lipids and health-related quality of life in older men.","volume":"3","author":"Kenny","year":"2000","journal-title":"Aging Male"},{"key":"2019041116332604300_R16","doi-asserted-by":"crossref","first-page":"967","DOI":"10.7326\/0003-4819-116-12-967","article-title":"Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels.","volume":"116","author":"Bagatell","year":"1992","journal-title":"Ann Intem Med"},{"key":"2019041116332604300_R17","first-page":"151","article-title":"Testosterone and risk factors for cardiovascular disease in men.","volume":"21","year":"1995","journal-title":"Diabetes Metab"},{"key":"2019041116332604300_R18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0026-0495(86)90011-9","article-title":"Relationships of serum lipoproteins and apolipoproteins to sex hormones and to the binding capacity of sex hormone binding globulin in healthy Finnish men.","volume":"35","author":"Hamalainen","year":"1986","journal-title":"Metabolism"},{"key":"2019041116332604300_R19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0021-9150(79)90067-4","article-title":"Sex hormones and high densitv lipoproteins in healthy mates.","volume":"34","author":"Nordoy","year":"1979","journal-title":"Atherosclerosis"},{"key":"2019041116332604300_R20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/acta.0.1040253","article-title":"Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin.","volume":"104","author":"Heller","year":"1983","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2019041116332604300_R21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/01.ATV.14.5.701","article-title":"The association of hypotestosteronemia with coronary artery disease in men.","volume":"14","author":"Phillips","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"2019041116332604300_R22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1210\/jcem-64-4-723","article-title":"Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subfractions in men.","volume":"64","author":"Stefanick","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R23","first-page":"1832","article-title":"Pharmacokinetics and metabolism of a permeation-enhanced testosterone transdermal system in hypogonadal men: influence of application site\u2013a clinical research center study.","volume":"81","author":"Meikle","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R24","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/S0022-5347(01)66141-X","article-title":"Improvement in sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system.","volume":"155","author":"Arver","year":"1996","journal-title":"J Urol"},{"key":"2019041116332604300_R25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0090-4295(96)00445-1","article-title":"Prostate size in hypogonadal men treated with a nonscrotal permeation-enhanced testosterone transdermal system.","volume":"49","author":"Meikle","year":"1997","journal-title":"Urology"},{"key":"2019041116332604300_R26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1365-2265.1997.3071113.x","article-title":"Long-term efficacy and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men.","volume":"47","author":"Arver","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041116332604300_R27","year":"1980"},{"key":"2019041116332604300_R28","author":"Bachorik","year":"1991"},{"key":"2019041116332604300_R29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative centrifuge.","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"2019041116332604300_R30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJM199108083250601","article-title":"A prospective study of cholesterol apolipoproteins, and the risk of myocardial infarction.","volume":"325","author":"Stampfer","year":"1991","journal-title":"N Engl J Med"},{"key":"2019041116332604300_R31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/clinchem\/38.4.569","article-title":"Normal variation of plasma lipoproteins: postural effects on plasma concentrations of lipids, lipoproteins, and apolipoproteins.","volume":"38","author":"Miller","year":"1992","journal-title":"Clin Chem"},{"key":"2019041116332604300_R32","author":"Place","year":"1990"},{"key":"2019041116332604300_R33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1001\/jama.1989.03420080085036","article-title":"Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.","volume":"261","author":"Thompson","year":"1989","journal-title":"JAMA"},{"key":"2019041116332604300_R34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0026-0495(90)90150-B","article-title":"High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered.","volume":"39","author":"Friedl","year":"1990","journal-title":"Metabolism"},{"key":"2019041116332604300_R35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/jcem-60-1-203","article-title":"Suppression of plasma testosterone leads to an increase in serum total and high density lipoprotein cholesterol and apoproteins a-i and b.","volume":"60","author":"Goldberg","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0026-0495(84)90222-1","article-title":"Severe depression of high-density lipoprotein cholesterol levels in weight lifters and body builders by self-administered exogenous testosterone and anabolic-androgenic steroids.","volume":"33","author":"Webb","year":"1984","journal-title":"Metabolism"},{"key":"2019041116332604300_R37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-2008-1025827","article-title":"Serum lipids in power athletes self-administering testosterone and anabolic steroids.","volume":"6","author":"Alen","year":"1985","journal-title":"Int J Sports Med"},{"key":"2019041116332604300_R38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1249\/00005768-198508000-00010","article-title":"Androgens reduce HDL2-cholesterol and increase hepatic triglyceride lipase activity.","volume":"17","author":"Kantor","year":"1985","journal-title":"Med Sci Sports Exerc"},{"key":"2019041116332604300_R39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0002-9343(58)90364-4","article-title":"The influence of androgens, estrogens and related steroids on serum lipids and lipoproteins\/observations in hypogonadal and normal human subjects.","volume":"24","author":"Furman","year":"1958","journal-title":"Am J Med"},{"key":"2019041116332604300_R40","first-page":"431","article-title":"Plasma testosterone, high density lipoproteins in healthy males.","volume":"34","author":"Gutai","year":"1981","journal-title":"Atherosclerosis"},{"key":"2019041116332604300_R41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0002-9343(89)80480-2","article-title":"Sex hormones and lipoproteins in men.","volume":"87","author":"Kiel","year":"1989","journal-title":"Am J Med"},{"key":"2019041116332604300_R42","first-page":"1","article-title":"Estradiol, testosterone, apolipoprotein, lipoprotein cholesterol and lipolytic enzymes in men without premature myocardial infarction and angiographically assesses coronary occlusion.","volume":"12","author":"Mendoza","year":"1983","journal-title":"Artery"},{"key":"2019041116332604300_R43","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/jcem-45-6-1211","article-title":"Low serum testosterone and sex-hormone-binding-globulin in massively obese men.","volume":"45","author":"Glass","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1210\/jcem-47-2-268","article-title":"Depressed plasma testosterone and fractional binding of testosterone in obese males.","volume":"47","author":"Amatruda","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R45","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1210\/jcem-71-4-929","article-title":"Plasma free and non-sex- hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity.","volume":"71","author":"Zumoff","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R46","first-page":"1140","article-title":"Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men.","volume":"76","author":"Vermeulen","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R47","first-page":"1821","article-title":"Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.","volume":"81","author":"Vermeulen","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R48","first-page":"997","article-title":"Pathogenesis of the decreased androgen levels in obese men.","volume":"79","author":"Giagulli","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cpt1975184377","article-title":"Commentary: a physiological approach to hepatic drug clearance.","volume":"18","author":"Wilkinson","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"2019041116332604300_R50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0026-0495(86)90206-4","article-title":"Androgen and estrogen metabolism: relationship to obesity.","volume":"35","author":"Longcope","year":"1986","journal-title":"Metabolism"},{"key":"2019041116332604300_R51","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1210\/jcem-73-3-609","article-title":"Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men.","volume":"73","author":"Finkelstein","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/jcem-73-3-621","article-title":"Sex steriod control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin- releasing hormone-deficient men.","volume":"73","author":"Finkelstein","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0026-0495(97)90299-7","article-title":"Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue.","volume":"46","author":"Ramirez","year":"1997","journal-title":"Metabolism"},{"key":"2019041116332604300_R54","first-page":"E820","article-title":"Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis","volume":"269","author":"Urban","year":"1995","journal-title":"Am J Physiol."},{"key":"2019041116332604300_R55","first-page":"991","article-title":"The effects of testosterone treatment on body composition and metabolism in middle aged obese men.","volume":"16","author":"Ma\u030arin","year":"1992","journal-title":"Int J Obesity"},{"key":"2019041116332604300_R56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199607043350101","article-title":"The effects of supraphysiologic doses of testosterone on muscle size and strength in men.","volume":"335","author":"Bhasin","year":"1996","journal-title":"N Engl J Med"},{"key":"2019041116332604300_R57","first-page":"4358","article-title":"Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.","volume":"81","author":"Katznelson","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R58","first-page":"3155","article-title":"Effects of testosterone replacement with a non-genital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels.","volume":"83","author":"Bhasin","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116332604300_R59","first-page":"IV116","article-title":"The epidemiology of plasma high-density lipoprotein cholesterol levels","volume":"62","author":"Heiss","year":"1980","journal-title":"The Lipid Research Clinics Program Prevalence Study Summary. Circulation."},{"key":"2019041116332604300_R60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2337\/diab.36.1.43","article-title":"Do upper-body and centralized adiposity measure different aspects of regional body-fat distribution? Relationship to non-insulin-dependent diabetes mellitus, lipids, and lipoproteins.","volume":"36","author":"Haffner","year":"1987","journal-title":"Diabetes"},{"key":"2019041116332604300_R61","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/01.CIR.81.5.1498","article-title":"Body fat distribution and male\/female differences in lipid and lipoprotein.","volume":"81","author":"Freedman","year":"1990","journal-title":"Circulation"},{"key":"2019041116332604300_R62","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/oxfordjournals.aje.a114704","article-title":"Sex hormones, insulin, lipids, and prevalent ischemic heart disease.","volume":"126","author":"Lichtenstein","year":"1987","journal-title":"Am J Epidemiol"},{"key":"2019041116332604300_R63","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1161\/01.CIR.100.16.1690","article-title":"Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease.","volume":"100","author":"Webb","year":"1999","journal-title":"Circulation"},{"key":"2019041116332604300_R64","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0002-9149(98)00880-7","article-title":"Effect of acute testosterone on myocardial ischemia in men with coronary artery disease.","volume":"83","author":"Webb","year":"1999","journal-title":"Am J Cardiol"},{"key":"2019041116332604300_R65","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1161\/01.CIR.99.13.1666","article-title":"Acute anti-ischemic effect of testosterone in men with coronary artery disease.","volume":"99","author":"Rosano","year":"1999","journal-title":"Circulation"},{"key":"2019041116332604300_R66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9150(96)05864-9","article-title":"The relationship of natural androgens to coronary heart disease in males: a review.","volume":"125","author":"Alexandersen","year":"1996","journal-title":"Atherosclerosis"},{"key":"2019041116332604300_R67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00045391-199905000-00008","article-title":"Testosterone and other anabolic steroids as cardiovascular drugs.","volume":"6","author":"Shapiro","year":"1999","journal-title":"Am J Ther"},{"key":"2019041116332604300_R68","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1177\/00912709922011809","article-title":"The effect of pharmacokinetically guided acute intravenous testosterone administration on electrocardiographic and blood pressure variables.","volume":"39","author":"White","year":"1999","journal-title":"J Clin Pharmacol"},{"key":"2019041116332604300_R69","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1532-5415.1993.tb02049.x","article-title":"Effects of testosterone replacement therapy in males: a preliminary study.","volume":"41","author":"Morley","year":"1993","journal-title":"J Am Geriatr Soc"},{"key":"2019041116332604300_R70","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1210\/jcem.82.6.3988","article-title":"Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial.","volume":"82","author":"Sih","year":"1997","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/86\/3\/1026\/9159916\/jcem1026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T15:48:51Z","timestamp":1597333731000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/86\/3\/1026\/2847480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.86.3.7285","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,1]]}}}