{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:34:02Z","timestamp":1751528042843},"reference-count":28,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"DOI":"10.1210\/jcem.86.4.7329","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:06:16Z","timestamp":1389200776000},"page":"1539-1544","source":"Crossref","is-referenced-by-count":2,"title":["Novel Assay for Determination of Androgen Bioactivity in Human Serum1"],"prefix":"10.1210","volume":"86","author":[{"given":"Taneli","family":"Raivio","sequence":"first","affiliation":[{"name":"Biomedicum Helsinki, Department of Physiology (T.R., J.J.P., O.A.J.), Institute of Biomedicine, University of Helsinki, FIN-00014 Helsinki;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma J.","family":"Palvimo","sequence":"additional","affiliation":[{"name":"Biomedicum Helsinki, Department of Physiology (T.R., J.J.P., O.A.J.), Institute of Biomedicine, University of Helsinki, FIN-00014 Helsinki;"},{"name":"Institute of Biotechnology (J.J.P.), University of Helsinki, FIN-00014 Helsinki;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Dunkel","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents (L.D., S.W.), University of Helsinki, FIN-00029 Huch;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Wickman","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents (L.D., S.W.), University of Helsinki, FIN-00029 Huch;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli A.","family":"Ja\u0308nne","sequence":"additional","affiliation":[{"name":"Biomedicum Helsinki, Department of Physiology (T.R., J.J.P., O.A.J.), Institute of Biomedicine, University of Helsinki, FIN-00014 Helsinki;"},{"name":"Department of Clinical Chemistry (O.A.J.), University of Helsinki, FIN-00014 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041121342732100_R1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell."},{"key":"2019041121342732100_R2","doi-asserted-by":"crossref","first-page":"29983","DOI":"10.1074\/jbc.270.50.29983","article-title":"Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer","volume":"270","author":"Langley","year":"1995","journal-title":"J Biol Chem."},{"key":"2019041121342732100_R3","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1021\/bi961775g","article-title":"Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand-binding domain of the androgen receptor","volume":"36","author":"Doesburg","year":"1997","journal-title":"Biochemistry."},{"key":"2019041121342732100_R4","doi-asserted-by":"crossref","first-page":"29821","DOI":"10.1074\/jbc.272.47.29821","article-title":"Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators","volume":"272","author":"Ikonen","year":"1997","journal-title":"J Biol Chem."},{"key":"2019041121342732100_R5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/mend.13.3.0255","article-title":"Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone","volume":"13","author":"Kemppainen","year":"1999","journal-title":"Mol Endocrinol."},{"key":"2019041121342732100_R6","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1074\/jbc.274.6.3700","article-title":"A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins","volume":"274","author":"Moilanen","year":"1999","journal-title":"J Biol Chem."},{"key":"2019041121342732100_R7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0014-5793(97)00791-6","article-title":"The presence of a transcription activation function in the hormone-binding domain of androgen receptor is revealed by studies in yeast cells","volume":"412","author":"Moilanen","year":"1998","journal-title":"FEBS Lett."},{"key":"2019041121342732100_R8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/0076-6879(87)52075-4","article-title":"Identification of regulatory elements of cloned genes with functional assays","volume":"152","author":"Rosenthal","year":"1987","journal-title":"Methods Enzymol."},{"key":"2019041121342732100_R9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1042\/bj3160993","article-title":"Characterization of cell-specific modulatory element in the murine ornithine decarboxylase promoter","volume":"316","author":"Palvimo","year":"1996","journal-title":"Biochem J."},{"key":"2019041121342732100_R10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1530\/eje.0.1420150","article-title":"Signaling between the pituitary gland and the testes: inverse relationship between serum follicle-stimulating hormone and inhibin B concentrations in boys in early puberty","volume":"142","author":"Raivio","year":"2000","journal-title":"Eur J Endocrinol."},{"key":"2019041121342732100_R11","author":"Tanner","year":"1962"},{"key":"2019041121342732100_R12"},{"key":"2019041121342732100_R13","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1203\/00006450-199911000-00002","article-title":"Inverse relationship between serum inhibin B and FSH levels in prepubertal boys with cryptorchidism","volume":"46","author":"Raivio","year":"1999","journal-title":"Pediatr Res."},{"key":"2019041121342732100_R14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/clinchem\/22.1.32","article-title":"Simultaneous determination of five sex hormones in human serum by radioimmunoassay after chromatography on Lipidex-5000","volume":"22","author":"Apter","year":"1976","journal-title":"Clin Chem."},{"key":"2019041121342732100_R15","author":"Dorfman","year":"1962"},{"key":"2019041121342732100_R16","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1172\/JCI117616","article-title":"Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay","volume":"94","author":"Klein","year":"1994","journal-title":"J Clin Invest."},{"key":"2019041121342732100_R17"},{"key":"2019041121342732100_R18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1749-6632.1988.tb48863.x","article-title":"Selective delivery of sex steroid hormones to tissues in vivo by albumin and by sex hormone-binding globulin","volume":"538","author":"Pardridge","year":"1988","journal-title":"Ann NY Acad Sci."},{"key":"2019041121342732100_R19","author":"Vermeulen","year":"1977"},{"key":"2019041121342732100_R20","first-page":"457","article-title":"The serum transport of steroid hormones","volume":"38","author":"Siiteri","year":"1982","journal-title":"Recent Prog Horm Res."},{"key":"2019041121342732100_R21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/edrv-10-3-232","article-title":"The free hormone hypothesis: a physiologically based mathematical model","volume":"10","author":"Mendel","year":"1989","journal-title":"Endocr Rev."},{"key":"2019041121342732100_R22","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"2019041121342732100_R23"},{"key":"2019041121342732100_R24","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1073\/pnas.94.14.7537","article-title":"Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone","volume":"94","author":"Morley","year":"1997","journal-title":"Proc Natl Acad Sci USA."},{"key":"2019041121342732100_R25","first-page":"3681","article-title":"Endogenous sex hormones and cognitive function in older men","volume":"84","author":"Barrett-Connor","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"2019041121342732100_R26","author":"Forest","year":"1993"},{"key":"2019041121342732100_R27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2265.1981.tb00653.x","article-title":"Indices of serum androgens in normal puberty: correlations of two indices with chronological age, bone age and pubertal development in boys and girls","volume":"15","author":"Penfold","year":"1981","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2019041121342732100_R28"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/86\/4\/1539\/9165229\/jcem1539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T15:48:49Z","timestamp":1597333729000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/86\/4\/1539\/2848321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.86.4.7329","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,1]]}}}