{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:15:36Z","timestamp":1783548936858,"version":"3.55.0"},"reference-count":58,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"DOI":"10.1210\/jcem.87.4.8362","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:08:03Z","timestamp":1389182883000},"page":"1509-1516","source":"Crossref","is-referenced-by-count":158,"title":["Differential Effects of Oral Estrogen<i>versus<\/i>Oral Estrogen-Androgen Replacement Therapy on Body Composition in Postmenopausal Women"],"prefix":"10.1210","volume":"87","author":[{"given":"Adrian S.","family":"Dobs","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine (A.S.D., T.N.), Baltimore, Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine (A.S.D., T.N.), Baltimore, Maryland 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Pace","sequence":"additional","affiliation":[{"name":"Solvay Pharmaceuticals, Inc. (C.P., C.P.R.), Marietta, Georgia 30062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla P.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Solvay Pharmaceuticals, Inc. (C.P., C.P.R.), Marietta, Georgia 30062"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113550228700_R1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/ajcn\/53.6.1378","article-title":"The relationship of menopause to skeletal and muscle mass","volume":"53","author":"Aloia","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t2019041113550228700_R2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0378-5122(98)00035-8","article-title":"The effect of menopause on regional and total body lean mass","volume":"29","author":"Douchi","year":"1998","journal-title":"Maturitas"},{"key":"key\n\t\t\t\t2019041113550228700_R3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ajcn\/70.3.405","article-title":"Aging, body composition and lifestyle: the Fels Longitudinal Study","volume":"70","author":"Guo","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t2019041113550228700_R4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1359\/jbmr.1997.12.1.144","article-title":"Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women?","volume":"12","author":"Chen","year":"1997","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113550228700_R5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00019501-199809080-00006","article-title":"Menopause, central body fatness and insulin resistance: effects of hormone replacement therapy","volume":"9","author":"Tchernof","year":"1998","journal-title":"Coron Artery Dis"},{"key":"key\n\t\t\t\t2019041113550228700_R6","first-page":"759","article-title":"The minimum effective dose of estrogen for prevention of postmenopausal bone loss","volume":"63","author":"Lindsay","year":"1984","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113550228700_R7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJM199803123381107","article-title":"Treatment of postmenopausal osteoporosis","volume":"338","author":"Eastell","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113550228700_R8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archneur.1994.00540210068014","article-title":"Estrogen replacement therapy in older women: comparisons between Alzheimer\u2019s disease cases and nondemented control subjects","volume":"51","author":"Henderson","year":"1994","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t2019041113550228700_R9","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.7326\/0003-4819-117-12-1016","article-title":"Hormone therapy to prevent disease and prolong life in postmenopausal women","volume":"117","author":"Grady","year":"1992","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113550228700_R10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0026-0495(89)90104-2","article-title":"Estrogen\/gestagen therapy changes soft tissue body composition in postmenopausal women","volume":"38","author":"Hassager","year":"1989","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113550228700_R11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00042192-199906040-00007","article-title":"Impact of hormone replacement therapy on body mass and fat compositions of menopausal women: a cross-sectional study","volume":"6","author":"Sayegh","year":"1999","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113550228700_R12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0026-0495(91)90037-W","article-title":"Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause","volume":"40","author":"Haarbo","year":"1991","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113550228700_R13","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/0002-9378(95)90018-7","article-title":"The influence of menopause and hormonal replacement therapy on body cell mass and body fat mass","volume":"3","author":"Aloia","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113550228700_R14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/ageing\/24.4.329","article-title":"Maximal muscle strength of elderly women is not influenced by estrogen status","volume":"24","author":"Taaffe","year":"1995","journal-title":"Age Ageing"},{"key":"key\n\t\t\t\t2019041113550228700_R15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/archinte.1995.00430030087010","article-title":"Is postmenopausal estrogen therapy associated with neuromuscular function or falling in elderly women?","volume":"155","author":"Seeley","year":"1995","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113550228700_R16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1046\/j.1365-2265.1998.00481.x","article-title":"Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women","volume":"48","author":"Hanggi","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113550228700_R17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0015-0282(16)56810-1","article-title":"The climacteric ovary as a functional gonadotropin-driven and androgen-producing gland","volume":"62","author":"Adashi","year":"1994","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113550228700_R18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1210\/jcem-42-2-247","article-title":"The hormonal activity of the postmenopausal ovary","volume":"42","author":"Vermeulen","year":"1976","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113550228700_R19","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1001\/jama.1941.02820520003002","article-title":"Androgen therapy in gynecology","author":"Geist","year":"1941","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113550228700_R20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1532-5415.1955.tb00880.x","article-title":"Low-dosage androgen-estrogen therapy in the older age group. Symposium presentation","volume":"3","author":"Brinbeg","year":"1955","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113550228700_R21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-0327(88)90061-4","article-title":"Affective changes with estrogen and androgen replacement therapy in surgically menopausal women","volume":"14","author":"Sherwin","year":"1988","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t2019041113550228700_R22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0002-9378(85)90001-8","article-title":"Differential symptom response to parenteral estrogen and or androgen administration in surgical menopause","volume":"2","author":"Sherwin","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019041113550228700_R23","first-page":"37","article-title":"Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women","volume":"81","author":"Raisz","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113550228700_R24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00042192-199906020-00011","article-title":"Differential effects of estrogen-androgen and estrogen only therapy on vasomotor symptoms, gonadotropin secretion, endogenous androgen biovailability in postmenopausal women","volume":"6","author":"Simon","year":"1999","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113550228700_R25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0378-5122(94)00898-H","article-title":"Testosterone enhances estradiol effects on postmenopausal bone density and sexuality","volume":"21","author":"Davis","year":"1995","journal-title":"Mautritas"},{"key":"key\n\t\t\t\t2019041113550228700_R26","first-page":"1012","article-title":"A two-year double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women: effects on bone mineral density, symptoms and lipid profiles","volume":"44","author":"Barrett-Connor","year":"1999","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t2019041113550228700_R27","first-page":"380","article-title":"Soft tissue body composition during prevention and treatment of postmenopausal osteoporosis assessed by photon absorptiometry","volume":"38","author":"Hassager","year":"1991","journal-title":"Dan Med Bull"},{"key":"key\n\t\t\t\t2019041113550228700_R28","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/0026-0495(81)90050-0","article-title":"Changes in body composition following therapy of osteoporosis with methandrostenolone","volume":"30","author":"Aloia","year":"1981","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113550228700_R29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-5122(98)00031-0","article-title":"Effect of percutaneous androgen replacement therapy on body composition and body weight in postmenopausal women","volume":"29","author":"Gruber","year":"1998","journal-title":"Maturitas"},{"key":"key\n\t\t\t\t2019041113550228700_R30","first-page":"2717","article-title":"Transdermal testosterone administration in women with acquired immunodeficiency syndrome wasting: a pilot study","volume":"83","author":"Miller","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113550228700_R31","first-page":"2839","article-title":"Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men","volume":"85","author":"Wang","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113550228700_R32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0969-8043(97)00099-7","article-title":"Fat free mass by bioelectrical impedance vs dual energy x-ray absorptiometry","volume":"49","author":"de Lorenzo","year":"1998","journal-title":"Appl Radiat Isot"},{"key":"key\n\t\t\t\t2019041113550228700_R33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0001-2998(97)80025-6","article-title":"Technical principals of dual energy x-ray absorptiometry","volume":"27","author":"Blake","year":"1997","journal-title":"Semin Nucl Mede"},{"key":"key\n\t\t\t\t2019041113550228700_R34","first-page":"64","article-title":"Validation of measurement of body composition from whole body bioelectric impedance analysis","volume":"17","author":"Shizgal","year":"1990","journal-title":"Infusionstherapie"},{"key":"key\n\t\t\t\t2019041113550228700_R35","first-page":"50","article-title":"Determination of whole body composition from whole body electrical impedance","volume":"39","author":"Jodoin","year":"1988","journal-title":"Surg Forum"},{"key":"key\n\t\t\t\t2019041113550228700_R36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/BF01541816","article-title":"Self-report assessment of female sexual function: pyschometric evaluation of Brief Index of Sexual Functioning for Women","volume":"23","author":"Taylor","year":"1994","journal-title":"Arch Sex Behav"},{"key":"key\n\t\t\t\t2019041113550228700_R37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1471-0528.1995.tb09138.x","article-title":"Measuring sexual functioning in premenopausal women","volume":"102","author":"Garratt","year":"1995","journal-title":"Brit J Ostet Gynaecol"},{"key":"key\n\t\t\t\t2019041113550228700_R38","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00042192-199805040-00084","article-title":"Sexual interest and functioning in postmenopausal women: a community-based national survey","volume":"5","author":"Sarrel","year":"1998","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113550228700_R39","article-title":"Clinical testing and preliminary validation of an androgen-sensitive menopausal quality of life scale (QUALMS)","author":"Juniper"},{"key":"key\n\t\t\t\t2019041113550228700_R40","first-page":"110","article-title":"Testosterone, body composition and aging","volume":"22","author":"Vermeulen","year":"1999","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113550228700_R41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4065\/75.4.386","article-title":"Treatment guidelines for HIV-associated wasting","volume":"75","author":"Nemechek","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"key\n\t\t\t\t2019041113550228700_R42","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00019501-199809080-00002","article-title":"Abdominal obesity and its metabolic complications: implications for the risk of ischemic heart disease","volume":"9","author":"Lamarche","year":"1998","journal-title":"Coron Artery Dis"},{"key":"key\n\t\t\t\t2019041113550228700_R43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0895-4356(91)90265-B","article-title":"Regional obesity and risk of cardiovascular disease; the Framingham Study","volume":"44","author":"Kannel","year":"1991","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041113550228700_R44","first-page":"371","article-title":"Effect of disuse on bone mineral density content, lean mass and fat mass in osteoarthritic patients","volume":"5","author":"Seo","year":"1990","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113550228700_R45","first-page":"E941","article-title":"Dual-energy x-ray absorptiometry body composition model: review of physical concepts","volume":"271","author":"Pietrobelli","year":"1996","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113550228700_R46","first-page":"E808","article-title":"Dual-energy x-ray absorptiometry: fat estimation errors due to variation in soft tissue hydration","volume":"274","author":"Pietrobelli","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113550228700_R47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199607043350101","article-title":"The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men","volume":"335","author":"Bhasin","year":"1996","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113550228700_R48","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/jama.283.6.763","article-title":"Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels","volume":"283","author":"Bhasin","year":"2000","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113550228700_R49","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0149-2918(97)80060-4","article-title":"Safety surveillance of esterified estrogens-methyltestosterone (Estratest and Estratest HS) replacement therapy in the United States","volume":"19","author":"Phillips","year":"1997","journal-title":"Clin Ther"},{"key":"key\n\t\t\t\t2019041113550228700_R50","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00042192-199906030-00007","article-title":"Liver function in postmenopausal women on estrogen-androgen hormone replacement therapy: a meta-analysis of eight clinical trials","volume":"6","author":"Gitlin","year":"1999","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113550228700_R51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0149-2918(97)80125-7","article-title":"Androgen and estrogen-androgen hormone replacement therapy: a review of safety literature 1941\u20131996","volume":"19","author":"Gelfand","year":"1997","journal-title":"Clin Ther"},{"key":"key\n\t\t\t\t2019041113550228700_R52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0026-0495(97)90159-1","article-title":"Determinants of sex hormone-binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status. Virgilio Menopause Health Group","volume":"46","author":"Pasquali","year":"1997","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113550228700_R53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen\/Progestin Research Group (HERS)","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113550228700_R54","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1001\/jama.282.21.2051","article-title":"An evidence-based assessment of the NCEP Adult Treatment Panel II guidelines. National Cholesterol Education Program","volume":"282","author":"Ansell","year":"1999","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113550228700_R55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0002-9149(98)00770-X","article-title":"Triglyceride as a risk factor for coronary artery disease","volume":"82","author":"Gotto","year":"1998","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113550228700_R56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/jwh.1998.7.195","article-title":"Preventing coronary heart disease in women: brief observation from the clinical data","volume":"7","author":"Gotto","year":"1998","journal-title":"J Womens Health"},{"key":"key\n\t\t\t\t2019041113550228700_R57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0002-9149(99)00209-X","article-title":"Epidemiology of hypertriglyceridemia and cardiovascular disease","volume":"83","author":"Austin","year":"1999","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113550228700_R58","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00006842-198707000-00009","article-title":"The role of androgen in the maintenance of sexual functioning in oophorectomized women","volume":"49","author":"Sherwin","year":"1987","journal-title":"Psychosom Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/87\/4\/1509\/10403121\/jcem1509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T20:52:57Z","timestamp":1565038377000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/87\/4\/1509\/2374936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":58,"aliases":["10.1210\/jc.87.4.1509"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.87.4.8362","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}