{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:42:17Z","timestamp":1777340537842,"version":"3.51.4"},"reference-count":21,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"DOI":"10.1210\/jcem.87.4.8385","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:08:03Z","timestamp":1389200883000},"page":"1669-1673","source":"Crossref","is-referenced-by-count":55,"title":["Relationship of Calpain-10 Genotype to Phenotypic Features of Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"87","author":[{"given":"David A.","family":"Ehrmann","sequence":"first","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E. H.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Medicine Biochemistry and Molecular Biology (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"the Howard Hughes Medical Institute (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Department of Medicine Biochemistry and Molecular Biology (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"the Howard Hughes Medical Institute (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Imperial","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme I.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"Department of Medicine Human Genetics (N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"Department of Medicine Biochemistry and Molecular Biology (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"the Howard Hughes Medical Institute (P.E.H.S., Y.H., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy J.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Medicine (D.A.E., M.H., X.T., J.I., N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"},{"name":"Department of Medicine Human Genetics (N.J.C., G.I.B.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113265163000_R1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1210\/er.16.3.322","article-title":"Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion","volume":"16","author":"Ehrmann","year":"1995","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113265163000_R2","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113265163000_R4","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R5","first-page":"2027","article-title":"Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives","volume":"86","author":"Colilla","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R6","first-page":"1299","article-title":"Glucose intolerance in the polycystic ovary syndrome: role of the pancreatic beta-cell","volume":"13","author":"Ehrmann","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R7","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1172\/JCI10665","article-title":"A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance","volume":"106","author":"Baier","year":"2000","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113265163000_R8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/mgme.2001.3171","article-title":"Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms","volume":"73","author":"Yang","year":"2001","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/79876","article-title":"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus","volume":"26","author":"Horikawa","year":"2000","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019041113265163000_R10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1086\/323315","article-title":"Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom","volume":"69","author":"Evans","year":"2001","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041113265163000_R11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0950-3552(97)80040-5","article-title":"Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus","volume":"11","author":"Ehrmann","year":"1997","journal-title":"Baillie\u0300re\u2019s Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113265163000_R12","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113265163000_R13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.2000.00884.x","article-title":"The prevalence of polycystic ovaries in women with type 2 diabetes mellitus","volume":"52","author":"Conn","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113265163000_R14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJM199207163270304","article-title":"Detection of functional ovarian hyperandrogenism in women with androgen excess","volume":"327","author":"Ehrmann","year":"1992","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113265163000_R15","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","volume-title":"Polycystic ovary syndrome","author":"Zawadzki","year":"1992"},{"key":"key\n\t\t\t\t2019041113265163000_R16","first-page":"772","article-title":"Insulin resistance is attenuated in PCOS women with the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-\u03b3 gene (PPARG)","volume":"87","author":"Hara","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R17","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"20","author":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"1997","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113265163000_R18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2337\/diab.12.2.115","article-title":"Immunoassay of insulin: two antibody systems: plasma insulin levels of normal, subdiabetic and diabetic rats","volume":"12","author":"Morgan","year":"1963","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113265163000_R19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/jcem-32-6-717","article-title":"Plasma testosterone binding globulin and indexes of the concentration of unbound androgens in normal and hirsute subjects","volume":"32","author":"Rosenfield","year":"1971","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113265163000_R20","first-page":"506","article-title":"Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)","volume":"52","author":"Spielman","year":"1993","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041113265163000_R21","first-page":"566","article-title":"Variation at the CAPN10 (calpain 10) gene and pathogenesis of polycystic ovarian syndrome: extended data demonstrates no evidence for a major role in Europoid populations","author":"Haddad"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/87\/4\/1669\/10405113\/jcem1669.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:53:15Z","timestamp":1565052795000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/87\/4\/1669\/2374963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.87.4.8385","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}