{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:09:53Z","timestamp":1792609793976,"version":"4.5.0"},"reference-count":19,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"DOI":"10.1210\/jcem.87.4.8430","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:08:03Z","timestamp":1389182883000},"page":"1762-1767","source":"Crossref","is-referenced-by-count":346,"title":["Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth"],"prefix":"10.1210","volume":"87","author":[{"given":"Gordon C. S.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology (G.C.S.S.), Cambridge University, CB2 2QQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Stenhouse","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine (E.J.S., A.D.C.), The Queen Mother\u2019s Hospital, Glasgow, G3 8SJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Crossley","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics (J.A.C., D.A.A., J.M.C.), Yorkhill National Health Service Trust, Glasgow, G3 8SJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics (J.A.C., D.A.A., J.M.C.), Yorkhill National Health Service Trust, Glasgow, G3 8SJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine (E.J.S., A.D.C.), The Queen Mother\u2019s Hospital, Glasgow, G3 8SJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Connor","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics (J.A.C., D.A.A., J.M.C.), Yorkhill National Health Service Trust, Glasgow, G3 8SJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113391089600_R1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/B978-0-407-00366-8.50022-8","article-title":"Regulation of fetal growth","volume-title":"Fetal physiology and medicine","author":"Gluckman","year":"1984"},{"key":"key\n\t\t\t\t2019041113391089600_R2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJM199812173392504","article-title":"First-trimester growth and the risk of low birth weight","volume":"339","author":"Smith","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113391089600_R3","volume-title":"Clinical applications of ultrasonic fetal measurements","author":"Evans","year":"1990"},{"key":"key\n\t\t\t\t2019041113391089600_R4","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1065::AID-PD695>3.0.CO;2-R","article-title":"The influence of smoking on maternal serum PAPP-A and free beta hCG levels in the first trimester of pregnancy","volume":"19","author":"Spencer","year":"1999","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113391089600_R5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1115::AID-PD3>3.0.CO;2-6","article-title":"Refinements in managing maternal weight adjustment for interpreting prenatal screening results","volume":"16","author":"Neveux","year":"1996","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113391089600_R6","volume-title":"Applied logistic regression","author":"Hosmer","year":"1989"},{"key":"key\n\t\t\t\t2019041113391089600_R7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0950-3552(87)80020-2","article-title":"Fetal monitoring. Biochemical methods","volume":"1","author":"Klopper","year":"1987","journal-title":"Baillieres Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113391089600_R8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<147::AID-PD231>3.0.CO;2-W","article-title":"Maternal serum levels of free beta-hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery","volume":"18","author":"Morssink","year":"1998","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019041113391089600_R9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/00016349509024379","article-title":"Human placental lactogen and pregnancy-associated plasma protein A in first trimester and subsequent fetal growth","volume":"74","author":"Pedersen","year":"1995","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t2019041113391089600_R10","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1093\/oxfordjournals.humrep.a137965","article-title":"Reduced circulating placental protein concentrations during the first trimester are associated with preterm labour and low birth weight","volume":"8","author":"Johnson","year":"1993","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113391089600_R11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.2000.tb11618.x","article-title":"First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications","volume":"107","author":"Ong","year":"2000","journal-title":"BJOG"},{"key":"key\n\t\t\t\t2019041113391089600_R12","first-page":"385","article-title":"Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome","volume":"40","author":"DiFranza","year":"1995","journal-title":"J Fam Pract"},{"key":"key\n\t\t\t\t2019041113391089600_R13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/acta.0.1190069","article-title":"Localization of mRNA for the beta-subunit of placental hCG by in situ hybridization","volume":"119","author":"Wide","year":"1988","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041113391089600_R14","first-page":"560","article-title":"Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta","volume":"71","author":"Bonno","year":"1994","journal-title":"Lab Invest"},{"key":"key\n\t\t\t\t2019041113391089600_R15","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","article-title":"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A","volume":"96","author":"Lawrence","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113391089600_R16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0303-7207(98)00024-0","article-title":"Role of insulin-like growth factor binding proteins in controlling IGF actions","volume":"140","author":"Clemmons","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113391089600_R17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0303-7207(98)00041-0","article-title":"The IGF system during fetal-placental development of the mouse","volume":"140","author":"Kleffens","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113391089600_R18","first-page":"249","article-title":"Insulin-like growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi","volume":"39","author":"Kniss","year":"1994","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t2019041113391089600_R19","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1093\/humrep\/14.suppl_2.90","article-title":"Role of the IGF system in trophoblast invasion and pre-eclampsia","volume":"14","author":"Irwin","year":"1999","journal-title":"Hum Reprod"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/87\/4\/1762\/10405932\/jcem1762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T20:53:20Z","timestamp":1565038400000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/87\/4\/1762\/2374978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.87.4.8430","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}