{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:55:32Z","timestamp":1790834132607,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>The polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular disease (CVD). Insulin resistance (IR), hyperandrogenism, and dyslipidemia are well-known cardiovascular risk factors in PCOS. Impaired fibrinolysis could also contribute to the development of CVD in PCOS. Global fibrinolytic capacity (GFC) is a recently developed method, which is reflected by the amount of generated D-dimer when the fibrinolysis of a freeze-dried fibrin clot is stopped by introducing aprotinin. GFC is sensitive to all the factors involved in the process of fibrinolysis. We evaluated whether women with PCOS have any alterations in the GFC and other essential hemostatic parameters. Fifty-nine nonobese, normal glucose-tolerant women with PCOS (age, 22.9 \u00b1 4.4 yr; body mass index, 23.0 \u00b1 2.4 kg\/m2 ) and 23 age- and body mass index-matched healthy controls participated. We measured GFC and triglycerides; total cholesterol; HDL-cholesterol (HDL-C); lipoprotein-a; prothrombin time; partial thromboplastin time; thrombin time; antithrombin III; factors II, V, VII, and X; fibrinogen; plasminogen; antiplasmin; and D-dimer. Serum glucose and insulin (at baseline and during a 75-g 2-h oral glucose tolerance test) were also measured, and IR was assessed by homeostatic model assessment. GFC was significantly lower in the PCOS group, compared with the control group (2.49 \u00b1 1.6 vs. 5.95 \u00b1 2.43 \u03bcg\/ml, P &amp;lt; 0.001). All the other coagulation and fibrinolysis parameters were comparable between the two groups. The PCOS group had lower HDL-C and higher IR values. GFC was correlated with testosterone and free testosterone negatively and with HDL-C positively. There was no correlation between GFC and any of the IR parameters. Our results suggest that women with PCOS have impaired fibrinolysis, as reflected by the decreased GFC. This impairment is not related to the IR and may increase the risk of CVD in PCOS.<\/jats:p>","DOI":"10.1210\/jcem.87.8.8716","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:08:23Z","timestamp":1389200903000},"page":"3871-3875","source":"Crossref","is-referenced-by-count":83,"title":["Global Fibrinolytic Capacity Is Decreased in Polycystic Ovary Syndrome, Suggesting a Prothrombotic State"],"prefix":"10.1210","volume":"87","author":[{"given":"Bu\u0308lent O.","family":"Yildiz","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism (B.O.Y., M.B.), Ankara, Turkey, 06100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u0307brahim C.","family":"Haznedaroglu","sequence":"additional","affiliation":[{"name":"Division of Hematology (I\u0307.C.H., S.K.), Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey, 06100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0327erafettin","family":"Kirazli","sequence":"additional","affiliation":[{"name":"Division of Hematology (I\u0307.C.H., S.K.), Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey, 06100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyase","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (B.O.Y., M.B.), Ankara, Turkey, 06100"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071619400189300_R1","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"2020071619400189300_R2","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study.","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619400189300_R3","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jcem.84.11.6148","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile.","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619400189300_R4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1067\/mob.2002.119180","article-title":"Polycystic ovary syndrome: a risk for coronary artery disease?","volume":"186","author":"Wild","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"2020071619400189300_R5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0895-4356(98)00035-3","article-title":"Mortality of women with polycystic ovary syndrome at long-term follow-up.","volume":"51","author":"Pierpoint","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"2020071619400189300_R6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2000.01000.x","article-title":"Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study.","volume":"52","author":"Wild","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619400189300_R7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2265.1992.tb02295.x","article-title":"Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome.","volume":"37","author":"Conway","year":"1992","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619400189300_R8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00016349209006227","article-title":"Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women.","volume":"71","author":"Dahlgren","year":"1992","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2020071619400189300_R9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0015-0282(16)54892-4","article-title":"Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones.","volume":"57","author":"Dahlgren","year":"1992","journal-title":"Fertil Steril"},{"key":"2020071619400189300_R10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2007-1016308","article-title":"Cardiovascular risk in women with polycystic ovarian syndrome.","volume":"14","author":"Guzick","year":"1996","journal-title":"Semin Reprod Endocrinol"},{"key":"2020071619400189300_R11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0015-0282(99)00468-9","article-title":"Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity.","volume":"73","author":"Mather","year":"2000","journal-title":"Fertil Steril"},{"key":"2020071619400189300_R12","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.ATV.15.7.821","article-title":"Coronary heart disease risk factors in women with polycystic ovary syndrome.","volume":"15","author":"Talbott","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071619400189300_R13","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/01.ATV.20.11.2414","article-title":"Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women.","volume":"20","author":"Talbott","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071619400189300_R14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1046\/j.1365-2265.1996.00863.x","article-title":"Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI-1) activity in lean women with and without the polycystic ovary syndrome.","volume":"45","author":"Sampson","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619400189300_R15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0015-0282(97)00486-X","article-title":"The plasminogen activator system in women with polycystic ovary syndrome.","volume":"69","author":"Atiomo","year":"1998","journal-title":"Fertil Steril"},{"key":"2020071619400189300_R16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0015-0282(16)56575-3","article-title":"Hemostatic and metabolic variables in women with polycystic ovary syndrome.","volume":"61","author":"Dahlgren","year":"1994","journal-title":"Fertil Steril"},{"key":"2020071619400189300_R17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2265.2000.00946.x","article-title":"Raised plasminogen activator inhibitor-1 (PAI-1) is not an independent risk factor in the polycystic ovary syndrome (PCOS).","volume":"52","author":"Atiomo","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071619400189300_R18","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0015-0282(00)01614-9","article-title":"Are women with polycystic ovary syndrome resistant to activated protein C?","volume":"74","author":"Atiomo","year":"2000","journal-title":"Fertil Steril"},{"key":"2020071619400189300_R19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM199503093321003","article-title":"Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group.","volume":"332","author":"Thompson","year":"1995","journal-title":"N Engl J Med"},{"key":"2020071619400189300_R20","first-page":"95","article-title":"The global fibrinolytic capacity.","volume":"10","author":"Amiral","year":"1996","journal-title":"Fibrinolysis"},{"key":"2020071619400189300_R21","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1161\/01.ATV.17.11.3071","article-title":"Effects of oral and transdermal estrogen\/progesterone regimens on blood coagulation and fibrinolysis in postmenopausal women. A randomized controlled trial.","volume":"17","author":"Scarabin","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071619400189300_R22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1055\/s-0037-1614338","article-title":"Elevated plasma fibrinogen and increased fibrin turnover among healthy women who both smoke and use low-dose oral contraceptives\u2014a preliminary report.","volume":"82","author":"Scarabin","year":"1999","journal-title":"Thromb Haemost"},{"key":"2020071619400189300_R23","first-page":"1","article-title":"Evaluation of the fibrinolytic potential on plasma: physiological and pathological variations, and associations with cardiovascular disease risk factors.","volume":"13","author":"Amiral","year":"1999","journal-title":"Fibrinolysis Proteol"},{"key":"2020071619400189300_R24","first-page":"177","article-title":"Global fibrinolytic capacity in healthy newborn infants.","volume":"43","author":"Yurdakok","year":"2001","journal-title":"Turk J Pediatr"},{"key":"2020071619400189300_R25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00296-001-0143-1","article-title":"Unchanged global fibrinolytic capacity despite increased factor VIIa activity in Behcet\u2019s disease: evidence of a prethrombotic state.","volume":"21","author":"Ozatli","year":"2002","journal-title":"Rheumatol Int"},{"key":"2020071619400189300_R26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/107602960200800105","article-title":"Diminished global fibrinolytic capacity in patients with mitral valve prolapse is associated with transient ischemic attacks.","volume":"8","author":"Atalar","year":"2002","journal-title":"Clin Appl Thromb Hemost"},{"key":"2020071619400189300_R27","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"2020071619400189300_R28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"2020071619400189300_R29","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1001\/archinte.1996.00440120032004","article-title":"Thrombosis in ischemic heart disease.","volume":"156","author":"Ambrose","year":"1996","journal-title":"Arch Intern Med"},{"key":"2020071619400189300_R30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00041433-199910000-00009","article-title":"Coagulation abnormalities and cardiovascular disease.","volume":"10","author":"DeLoughery","year":"1999","journal-title":"Curr Opin Lipidol"},{"key":"2020071619400189300_R31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/1047-2797(92)90092-5","article-title":"On the role of coagulation and fibrinolysis in atherosclerosis.","volume":"2","author":"Juhan-Vague","year":"1992","journal-title":"Ann Epidemiol"},{"key":"2020071619400189300_R32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(86)90111-X","article-title":"Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study.","volume":"2","author":"Meade","year":"1986","journal-title":"Lancet"},{"key":"2020071619400189300_R33","first-page":"20","article-title":"The global fibrinolytic capacity.","volume":"8","author":"Amiral","year":"1997","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2020071619400189300_R34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1055\/s-2007-994940","article-title":"Acquired defects of fibrinolysis associated with thrombosis.","volume":"25","author":"Fareed","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"2020071619400189300_R35","first-page":"3030","article-title":"Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome.","volume":"84","author":"Thierry van Dessel","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071619400189300_R36","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1055\/s-0038-1649716","article-title":"The effects of insulin-like growth factor-1 on plasminogen activator inhibitor-1 synthesis and secretion: results from in vitro and in vivo studies.","volume":"70","author":"Padayatty","year":"1993","journal-title":"Thromb Haemost"},{"key":"2020071619400189300_R37","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7326\/0003-4819-132-12-200006200-00010","article-title":"The importance of diagnosing the polycystic ovary syndrome.","volume":"132","author":"Lobo","year":"2000","journal-title":"Ann Intern Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/87\/8\/3871\/9158669\/jcem3871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/87\/8\/3871\/9158669\/jcem3871.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T04:40:51Z","timestamp":1594960851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/87\/8\/3871\/2847253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,1]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcem.87.8.8716","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,1]]}}}