{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:37Z","timestamp":1753883557631,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>COVID-19 is a systemic disease associated with respiratory insufficiency, systemic inflammation, as well as coagulation, neurological, and endocrine disorders. Among them pituitary apoplexy (PA) as well as, more rarely, acute hypophysitis (AH) have been reported. In the present report, we described a case of PA in an 84-year-old man with SARS-CoV-2 pneumonia, with a previous unknown pituitary adenoma and a possible but not confirmed overlap with transitory AH. After reviewing the available literature, we discuss the potential clinical and pathophysiological relationship between PA and AH. Furthermore, we focus on the neuroradiological features of pituitary lesions in the presence of SARS-CoV-2 infection.<\/jats:p>","DOI":"10.1210\/jcemcr\/luac010","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T09:22:13Z","timestamp":1669713733000},"source":"Crossref","is-referenced-by-count":0,"title":["Pituitary Apoplexy With Transition to Acute Hypophysitis in a Patient With Sars-CoV-2 Pneumonia"],"prefix":"10.1210","volume":"1","author":[{"given":"Giulia","family":"Racca","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine, Hospital S. Croce & Carle Cuneo, Cuneo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"D\u2019Agnano","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Medicine, Hospital S. Croce & Carle Cuneo, Cuneo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Fasano","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology, Hospital S. Croce & Carle Cuneo, Cuneo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-2468","authenticated-orcid":false,"given":"Laura","family":"Gianotti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, S. Croce & Carle Hospital Cuneo, Cuneo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"issue":"3","key":"2023100215462373000_luac010-B1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11102-021-01148-1","article-title":"COVID-19 and the pituitary","volume":"24","author":"Frara","year":"2021","journal-title":"Pituitary"},{"issue":"6","key":"2023100215462373000_luac010-B2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/er.2015-1042","article-title":"Pituitary apoplexy","volume":"36","author":"Briet","year":"2015","journal-title":"Endocr Rev"},{"key":"2023100215462373000_luac010-B3","doi-asserted-by":"crossref","first-page":"e678","DOI":"10.1016\/j.wneu.2021.06.004","article-title":"Coronavirus disease 2019 and pituitary apoplexy: a single-center case series and review of the literature","volume":"152","author":"Martinez-Perez","year":"2021","journal-title":"World Neurosurg"},{"issue":"6","key":"2023100215462373000_luac010-B4","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s11102-020-01080-w","article-title":"Pituitary apoplexy associated with acute COVID-19 infection and pregnancy","volume":"23","author":"Chan","year":"2020","journal-title":"Pituitary"},{"issue":"2","key":"2023100215462373000_luac010-B5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2265.2005.02325.x","article-title":"Hypocortisolism in survivors of severe acute respiratory syndrome (SARS)","volume":"63","author":"Leow","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2023100215462373000_luac010-B6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4103\/ijem.ijem_329_21","article-title":"Hypophysitis after COVID-19 infection","volume":"25","author":"Nonglait","year":"2021","journal-title":"Indian J Endocrinol Metab"},{"key":"2023100215462373000_luac010-B7","doi-asserted-by":"crossref","DOI":"10.1177\/2329048X221103051","article-title":"Post COVID-19 lymphocytic hypophysitis: a rare presentation","volume":"9","author":"Joshi","year":"2022","journal-title":"Child Neurol Open"},{"issue":"12","key":"2023100215462373000_luac010-B8","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1007\/s40618-021-01627-z","article-title":"Central diabetes insipidus (infundibuloneuro hypophysitis): a late complication of COVID-19 infection","volume":"44","author":"Misgar","year":"2021","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"2023100215462373000_luac010-B9","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1530\/EJE-17-0009","article-title":"Mechanisms in endocrinology: hypophysitis: diagnosis and treatment","volume":"179","author":"Joshi","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"2023100215462373000_luac010-B10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.25259\/SNI_338_2020","article-title":"Parasellar T2 dark sign on magnetic resonance imaging to differentiate lymphocytic hypophysitis from pituitary adenoma","volume":"11","author":"Agarwal","year":"2020","journal-title":"Surg Neurol Int"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac010\/51825503\/luac010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac010\/51825503\/luac010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:46:53Z","timestamp":1696261613000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luac010\/6849909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luac010","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,29]]},"article-number":"luac010"}}