{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:42Z","timestamp":1753883622983,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006784","name":"Golfers Against Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006784","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Clinical syndromes involving multiple endocrine glands have been well recognized for over a century. Multiple reports describing hereditary multiple endocrine neoplasia (MEN) syndromes involving pituitary, parathyroid, and pancreatic neuroendocrine tumors have been published. Differentiated (nonmedullary) thyroid cancer can also present as a hereditary syndrome with or without a specific genetic predisposition. We report the case of a man with nonsyndromic familial nonmedullary thyroid carcinoma, a pituitary adenoma, hyperparathyroidism, an adrenal adenoma, and pancreatic adenocarcinoma. Genetic testing did not reveal mutations in the commonly reported genes associated with MEN syndromes. MEN1 is characterized by endocrine neoplasia in at least 2 of the following glands: pituitary, parathyroid, and the gastro-entero-pancreatic (GEP) tract. Co-occurrence of MEN1 with familial nonmedullary thyroid carcinoma, however, has not been reported in the medical literature. This unique case of MEN1 co-existing in a patient with nonsyndromic familial thyroid carcinoma was not associated with any common MEN syndrome germline mutations.<\/jats:p>","DOI":"10.1210\/jcemcr\/luac019","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T15:20:15Z","timestamp":1669735215000},"source":"Crossref","is-referenced-by-count":1,"title":["MEN1 in a Patient With Nonsyndromic Familial Nonmedullary Thyroid Carcinoma"],"prefix":"10.1210","volume":"1","author":[{"given":"Lauren A","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"ENMED Program, Texas A&M University , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Williamson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Houston Methodist Hospital , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawairia","family":"Shakil","sequence":"additional","affiliation":[{"name":"ENMED Program, Texas A&M University , Houston, TX 77030 , USA"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Houston Methodist Hospital , Houston, TX 77030 , USA"},{"name":"Weill Cornell Medical College , New York, NY 10021 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-5199","authenticated-orcid":false,"given":"Richard J","family":"Robbins","sequence":"additional","affiliation":[{"name":"ENMED Program, Texas A&M University , Houston, TX 77030 , USA"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Houston Methodist Hospital , Houston, TX 77030 , USA"},{"name":"Weill Cornell Medical College , New York, NY 10021 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"issue":"1","key":"2023100215460831200_luac019-B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/jcem-13-1-20","article-title":"Multiple endocrine adenomas; report of 8 cases in which the parathyroids, pituitary and pancreatic islets were involved","volume":"13","author":"Underdahl","year":"1953","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023100215460831200_luac019-B2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9343(54)90353-8","article-title":"Genetic aspects of adenomatosis of endocrine glands","volume":"16","author":"Wermer","year":"1954","journal-title":"Am J Med"},{"issue":"8","key":"2023100215460831200_luac019-B3","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/imj.14394","article-title":"Multiple endocrine neoplasia: an update","volume":"49","author":"McDonnell","year":"2019","journal-title":"Intern Med J"},{"issue":"2","key":"2023100215460831200_luac019-B4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jmoldx.2018.10.009","article-title":"A rigorous interlaboratory examination of the need to confirm next-generation sequencing-detected variants with an orthogonal method in clinical genetic testing","volume":"21","author":"Lincoln","year":"2019","journal-title":"J Mol Diagn"},{"issue":"1","key":"2023100215460831200_luac019-B5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.surg.2020.04.067","article-title":"Understanding the clinical course of genotype negative MEN1 patients can inform management strategies","volume":"169","author":"Pieterman","year":"2020","journal-title":"Surgery"},{"issue":"5","key":"2023100215460831200_luac019-B6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s40618-020-01435-x","article-title":"Familial non-medullary thyroid cancer: a critical review","volume":"44","author":"Capezzone","year":"2021","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2023100215460831200_luac019-B7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2169\/internalmedicine.54.2782","article-title":"Poorly controlled acromegaly accompanied by subclinical adrenal Cushing's syndrome after surgery for multiple endocrine tumors","volume":"54","author":"Ishikawa","year":"2015","journal-title":"Intern Med"},{"issue":"4","key":"2023100215460831200_luac019-B8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.endinu.2021.04.012","article-title":"Clinical characteristics and prognosis of familial nonmedullary thyroid carcinoma","volume":"69","author":"de Carlos Artajo","year":"2022","journal-title":"Endocrinol Diabetes Nutr"},{"key":"2023100215460831200_luac019-B9","doi-asserted-by":"crossref","first-page":"845954","DOI":"10.3389\/fendo.2022.845954","article-title":"Risk of second malignant neoplasm in familial non-medullary thyroid cancer patients","volume":"13","author":"Capezzone","year":"2022","journal-title":"Front Endocrinol"},{"key":"2023100215460831200_luac019-B10","doi-asserted-by":"crossref","first-page":"829103","DOI":"10.3389\/fendo.2022.829103","article-title":"Susceptibility genes and chromosomal regions associated with non-syndromic familial non-medullary thyroid carcinoma: some pathogenetic and diagnostic keys","volume":"13","author":"S\u00e1nchez-Ares","year":"2022","journal-title":"Front Endocrinol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/advance-article-pdf\/doi\/10.1210\/jcemcr\/luac019\/47464414\/luac019.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac019\/51825161\/luac019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac019\/51825161\/luac019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:46:42Z","timestamp":1696261602000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luac019\/6855029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luac019","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,29]]},"article-number":"luac019"}}