{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:59Z","timestamp":1753883519051,"version":"3.41.2"},"reference-count":9,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 21-year-old female presented to the hospital with acute onset left pelvic pain that began while urinating. Ultrasound of the pelvis revealed a 1.7\u2005cm structure within the bladder wall. Follow-up imaging with magnetic resonance imaging confirmed a 1.9\u2005cm mass in the urinary bladder wall. Cystoscopy with transurethral resection was performed. Histopathology of the obtained tissue confirmed the diagnosis of paraganglioma. Laboratory evaluation revealed evidence of catecholamine excess with elevated urine norepinephrine, urine normetanephrine, and plasma free normetanephrine. Functional imaging with Ga-DOTATATE positron emission tomography-computed tomography (PET-CT) revealed increased uptake in the region of the known mass without findings of metastasis. Genetic testing revealed succinate dehydrogenase A mutation, consistent with paraganglioma syndrome 5. The patient was treated with alpha-adrenergic blockade prior to partial cystectomy. Urinary bladder paraganglioma is a rare entity. The diagnosis requires a high index of clinical suspicion due to variable presentation. Hypertension and other signs of catecholamine excess, especially in relation to micturition, are important clues. Despite evidence of catecholamine excess in most patients with bladder paraganglioma, the majority are diagnosed after biopsy, indicating a need for improved diagnostic strategies in this patient population. Early diagnosis and treatment are essential to prevent potentially lethal cardiac complications and tumor metastasis.<\/jats:p>","DOI":"10.1210\/jcemcr\/luac026","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:46:38Z","timestamp":1673415998000},"source":"Crossref","is-referenced-by-count":0,"title":["Bladder Paraganglioma Associated With Succinate Dehydrogenase A Mutation Presenting as Pelvic Pain"],"prefix":"10.1210","volume":"1","author":[{"given":"Gurbir","family":"Hehar","sequence":"first","affiliation":[{"name":"Beaumont Hospital Royal Oak, Royal Oak, MI 48073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Rahmon","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine, Rochester, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajaz","family":"Banka","sequence":"additional","affiliation":[{"name":"Beaumont Hospital Royal Oak, Royal Oak, MI 48073 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"issue":"6","key":"2023100215454034400_luac026-B1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMra1806651","article-title":"Pheochromocytoma and paraganglioma","volume":"381","author":"Neumann","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"2023100215454034400_luac026-B2","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1210\/clinem\/dgaa965","article-title":"Incidence and clinical presentation of pheochromocytoma and sympathetic paraganglioma: a population-based study","volume":"106","author":"Ebbehoj","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023100215454034400_luac026-B3","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1210\/jc.2009-2830","article-title":"A current review of the etiology, diagnosis, and treatment of pediatric pheochromocytoma and paraganglioma","volume":"95","author":"Waguespack","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2023100215454034400_luac026-B4","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1210\/clinem\/dgac427","article-title":"Presentation, management, and outcomes of urinary bladder paraganglioma: results from a multi-center study","volume":"107","author":"Yu","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023100215454034400_luac026-B5","doi-asserted-by":"publisher","first-page":"101416","DOI":"10.1016\/j.beem.2020.101416","article-title":"An overview of 20 years of genetic studies in pheochromocytoma and paraganglioma","volume":"34","author":"Buffet","year":"2020","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"2023100215454034400_luac026-B6","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023100215454034400_luac026-B7","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1210\/jc.2017-01762","article-title":"Clinical aspects of SDHA-related pheochromocytoma and paraganglioma: a nationwide study","volume":"103","author":"Van Der Tuin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023100215454034400_luac026-B8","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jviscsurg.2011.07.003","article-title":"Pheochromocytoma and abdominal paraganglioma","volume":"148","author":"Renard","year":"2011","journal-title":"J Visc Surg"},{"issue":"2","key":"2023100215454034400_luac026-B9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00345-021-03851-x","article-title":"Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review","volume":"40","author":"Li","year":"2022","journal-title":"World J Urol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac026\/51825581\/luac026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac026\/51825581\/luac026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:46:05Z","timestamp":1696261565000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luac026\/6983654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luac026","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,29]]},"article-number":"luac026"}}