{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:38:45Z","timestamp":1783042725691,"version":"3.54.6"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary aldosteronism (PA) is a major cause of secondary hypertension. Aldosterone-producing adenoma (APA) is a subtype of PA, and adrenalectomy is the gold-standard treatment. Recently, a high prevalence of the KCNJ5 gene mutation has been reported in APA, particularly in Japan. Herein, we present 2 extremely rare cases of PA recurrence more than 10 years after adrenalectomy for APA. In the first case, a 52-year-old woman was examined for hypertension 22 years after total adrenalectomy of the right adrenal gland. Recurrent PA was diagnosed based on high aldosterone-renin-ratio (ARR), identification of left adrenal gland tumor by computed tomography (CT), and a confirmatory test. In the second case, a 65-year-old man was examined for hypertension 17 years after total adrenalectomy of the left adrenal gland. He had maintained his blood pressure using medication since the onset of hypertension 4 years after the surgery. A year later, a high ARR was observed. PA recurrence was determined by a right adrenal gland tumor noted on CT and a confirmatory test. Somatic mutations in KCNJ5 were detected in the resected tissues in both cases. We recommend careful follow-ups after adrenalectomy in APA cases, especially in those with a KCNJ5 gene mutation.<\/jats:p>","DOI":"10.1210\/jcemcr\/luac032","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:46:47Z","timestamp":1673416007000},"source":"Crossref","is-referenced-by-count":3,"title":["Recurrence of Primary Aldosteronism After Surgery in Aldosterone-producing Adenoma With <i>KCNJ5<\/i> Gene Mutation"],"prefix":"10.1210","volume":"1","author":[{"given":"Ko","family":"Aiga","sequence":"first","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-3018","authenticated-orcid":false,"given":"Mitsuhiro","family":"Kometani","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Aono","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"issue":"4","key":"2023100215472444200_luac032-B1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1507\/endocrj.EJ21-0508","article-title":"Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021","volume":"69","author":"Naruse","year":"2022","journal-title":"Endocr J"},{"issue":"2","key":"2023100215472444200_luac032-B2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00423-009-0498-4","article-title":"Long-term effects of surgical correction of adrenal hyperplasia and adenoma causing primary aldosteronism","volume":"395","author":"Hennings","year":"2010","journal-title":"Langenbecks Arch Surg"},{"issue":"3","key":"2023100215472444200_luac032-B3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00423-014-1269-4","article-title":"Outcome of surgical treatment of primary aldosteronism","volume":"400","author":"Citton","year":"2015","journal-title":"Langenbecks Arch Surg"},{"issue":"893","key":"2023100215472444200_luac032-B4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/pmj.76.893.160","article-title":"Recurrence of adrenal aldosterone-producing adenoma","volume":"76","author":"Calvo-Romero","year":"2000","journal-title":"Postgrad Med J"},{"key":"2023100215472444200_luac032-B5","doi-asserted-by":"crossref","first-page":"728595","DOI":"10.3389\/fendo.2021.728595","article-title":"Recurrence of primary aldosteronism 10 years after left adrenalectomy for aldosterone-producing adenoma: a case report","volume":"12","author":"Kong","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2023100215472444200_luac032-B6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jfma.2012.01.009","article-title":"Recurrence of primary aldosteronism after percutaneous ethanol injection","volume":"111","author":"Chang","year":"2012","journal-title":"J Formos Med Assoc"},{"issue":"11","key":"2023100215472444200_luac032-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0337-9","article-title":"Genetic causes of primary aldosteronism","volume":"51","author":"Seidel","year":"2019","journal-title":"Exp Mol Med"},{"issue":"2","key":"2023100215472444200_luac032-B8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1148\/radiol.2016152277","article-title":"Aldosterone-producing adenoma in primary aldosteronism: CT-guided radiofrequency ablation-long-term results and recurrence rate","volume":"281","author":"Liu","year":"2016","journal-title":"Radiology"},{"issue":"6","key":"2023100215472444200_luac032-B9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/a-1128-0421","article-title":"The potential role of aldosterone-producing cell clusters in adrenal disease","volume":"52","author":"Lim","year":"2020","journal-title":"Horm Metab Res"},{"issue":"40","key":"2023100215472444200_luac032-B10","doi-asserted-by":"crossref","first-page":"26007","DOI":"10.18632\/oncotarget.25418","article-title":"Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism","volume":"9","author":"Kometani","year":"2018","journal-title":"Oncotarget"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac032\/51825278\/luac032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/1\/luac032\/51825278\/luac032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:48:00Z","timestamp":1696261680000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luac032\/6983655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,29]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luac032","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,29]]},"article-number":"luac032"}}